Results 11 to 20 of about 255 (109)

Pyrrolo-Fused Phenanthridines as Potential Anticancer Agents: Synthesis, Prediction, and Biological Evaluation. [PDF]

J Biochem Mol Toxicol
ABSTRACT We report the synthesis of four novel monoquaternary salts and four fused pyrrolo‐phenanthridine compounds, fully characterized by NMR, FT‐IR, and mass spectrometry. Guided by theoretical predictions, including molecular docking studies, we assessed their cytotoxic activity and biocompatibility.
Al-Matarneh A, Simionescu N, Nicolescu A, Cibotariu N, Danac R, Al-Matarneh MC, Mangalagiu II.   +6 more
europepmc   +2 more sources

Fluorescent Carbazole-Derived Aza[5]Helicenes: Synthesis, Functionalization, and Characterization. [PDF]

Chemistry
Variously substituted indolophenanthridines, indolocarbazoles, and cinnolinocarbazoles synthesized by ortho fusion from teraryl precursors show significant Stokes shifts, especially for the protonated states of indolophenanthridines and cinnolinocarbazole.
Marten I, Dilanas MEA, Podlech J.
europepmc   +2 more sources

Site-Selective Ligand Functionalization Reverses Hypsochromic Luminescence Shifts in Platinum(II) Complexes of Benzannulated NCN-Coordinating Ligands. [PDF]

Chemistry
Reversing the Trend: Phenanthridine (benzo[c]quinoline) donors defy conventional logic that increasing ligand benzannulation leads to bathochromic (red) shifts in the absorption and emission of their coordination complexes. Here, we provide a counterfactual that reverses this trend: substitution at the phenanthridine 6‐position (i.
Ortiz RJ, Garcia-Torres E, Brothwood PL, Williams JAG, Herbert DE.   +4 more
europepmc   +2 more sources

In Pursuit of Low Energy Phosphorescence: Late Metal Coordination Complexes of the Planar, π-extended Bipyridyl Ligand 6,6',7,7'-Biphenanthridine. [PDF]

Chemistry
Abstract The coordination chemistry of the planar, doubly π‐extended bipyridine analog, 6,6′,7,7′‐biphenanthridine (p‐biphe), is presented. The phenanthridine units in p‐biphe are fused together at the 6‐ and 7‐ positions, and the resulting rigid ligand is compared with the more flexible parent “biphe” fused only at the 6‐positions.
Nemez DB, Ortiz RJ, Veilleux KA, Williams JAG, Herbert DE.   +4 more
europepmc   +2 more sources

Electrochemical Syntheses of Polycyclic Aromatic Hydrocarbons (PAHs)

Advanced Materials, Volume 35, Issue 49, December 7, 2023., 2023
Polycyclic aromatic hydrocarbons (PAHs) are widely applied in optoelectronics and material sciences. In the past decade, molecular electrochemistry has emerged as a novel and robust tool for PAHs synthesis. This review provides a comprehensive survey on electrochemical assembly of PAHs largely by the hydrogen evolution reaction.
Yulei Wang, Rong Zhao, Lutz Ackermann
wiley   +1 more source

Chinese Herbal Medicines for Diabetic Cardio‐Cerebrovascular Diseases: Key Bioactive Metabolites and Action Mechanisms

Journal of Nutrition and Metabolism, Volume 2026, Issue 1, 2026.
Currently, the global incidence of diabetes is increasing, particularly in populous developing regions. In China, over 290 million people are affected by diabetic cardio‐cerebrovascular diseases. These diseases account for more than 40% of deaths and impose a significant economic burden on both society and families.
Ying Su, Shuwen Luo, Wei Li, Cuicui Cheng, Wei Liu, Xinyu Yang, Zhen Xing, Eric Gumpricht   +7 more
wiley   +1 more source

Rapid Access to Emission‐Tunable Organelle‐Targeted Aggregation‐Induced Emission Luminogens Through One‐Pot Skeletal Editing

Transformative Chemistry, Volume 1, Issue 1, December 2025.
Herein we report a skeletal editing strategy for rapidly transforming readily available isoquinolines into synthetically challenging (dihydrodibenzo[c,i]phenanthridin‐6‐yl)diphenylphosphine oxides (DHBPPO) derivatives. These DHBPPO derivatives exhibit tunable emission, aggregation‐induced emission (AIE) properties, organelle‐targeted specificity, and ...
Yanling Liu, Chaoyang Li, Yunlong Qin, Yifan Cheng, Jianing Zhang, Yang Zhao, Tianhao Wu, Chenghan He, Cheng Xu, Qilin Wang, Zheng Zhao, Ben Zhong Tang   +11 more
wiley   +1 more source

The Quinoline Photoremovable Group (PPG) Platform—A Medicinal Chemist's Approach for Photocage Development and Applications

Medicinal Research Reviews, Volume 45, Issue 5, Page 1423-1451, September 2025.
ABSTRACT Photoremovable protecting groups (PPGs) offer a straightforward solution for the temporary inactivation of biologically active substrates and their subsequent controlled release by light irradiation. Their relatively easy design and mode of application have made them useful tools for studying dynamic biological processes in vitro and in vivo ...
Bence Kontra, Zoltán Mucsi, Janez Ilaš, Petra Dunkel   +3 more
wiley   +1 more source

Electrochemical Hydrogenation of N‐Heterocycles and Related Substrates: A Mini‐Review

Electrochemical Science Advances, Volume 5, Issue 4, August 2025.
ABSTRACT Catalytic hydrogenation refers to the (often) metal‐mediated addition of dihydrogen (H2) equivalents to unsaturated compounds to form new element‐hydrogen bonds. This conceptually simple reaction is ubiquitous in the production of a vast number of essential chemicals.
Esteban Garcia‐Torres, David E. Herbert   +1 more
wiley   +1 more source

Leveraging Tumor Microenvironment to Boost Synergistic Photodynamic Therapy, Ferroptosis Anti‐Tumor Efficiency Based on a Functional Iridium(III) Complex

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Ingenious introduction of an imine bond into an Ir(III)‐ferrocene complex effectively disrupts the photoinduced electron transfer process. Allowing full use of the TME to boost the efficacy of PDT, the molecule releases the Ir(III) complex and ferrocene with synergistic enhanced therapeutic effects of PDT and ferroptosis.
Yu Pei, Yinzhen Pan, Zhijun Zhang, Jun Zhu, Yan Sun, Qian Zhang, Dongxia Zhu, Guangzhe Li, Martin R. Bryce, Dong Wang, Ben Zhong Tang   +10 more
wiley   +1 more source