Results 201 to 210 of about 32,293 (248)
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2014
Cigarette smoking is the leading cause of preventable death in the United States. While there are more than 4,000 chemicals found in tobacco smoke, the polycyclic aromatic hydrocarbons (PAHs) have been clearly demonstrated to contribute to smoking-related cancers.
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Cigarette smoking is the leading cause of preventable death in the United States. While there are more than 4,000 chemicals found in tobacco smoke, the polycyclic aromatic hydrocarbons (PAHs) have been clearly demonstrated to contribute to smoking-related cancers.
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Transplacental action of benzo(a)pyrene and pyrene
Bulletin of Experimental Biology and Medicine, 1977The transplacental and direct action of benzo(a)pyrene (BP) on mice of strains A and C57BL and of their progeny was studied. BP was found to represent a carcinogenic risk for the progeny. The greatest carcinogenic effect in progeny of strain A mice was exhibited by BP in a dose of 6 mg: The frequency of development of lung tumors was 76.8% compared ...
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Histochemistry, 1974
A microspectrofluorometric approach in conjunction with microelectrophoretic injection of glucose-6-P (G6P), was used to study the effect of cultivation in a benzo(a)pyrene (BP)-containing medium on the metabolization of BP, by EL2 ascites cells. The fluorescence increase which follows the microinjection of G6P to single living cells.
J M, Salmon +3 more
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A microspectrofluorometric approach in conjunction with microelectrophoretic injection of glucose-6-P (G6P), was used to study the effect of cultivation in a benzo(a)pyrene (BP)-containing medium on the metabolization of BP, by EL2 ascites cells. The fluorescence increase which follows the microinjection of G6P to single living cells.
J M, Salmon +3 more
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Benzo[a]pyrene 7,8-dihydrodiol is more carcinogenic than benzo[a]pyrene in newborn mice
Nature, 1977THE pioneering research by James and Elizabeth Miller relating the carcinogenic effects of many chemicals to the metabolism of these compounds to reactive intermediates which bind to critical cellular compoenents1,2 led to studies of the nature and chemical structure of these reactive metabolites (ultimate carcinogens) and their metabolic precursors ...
J, Kapitulnik +4 more
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Analytical Biochemistry, 1976
Abstract A simple radioassay method is described to measure specifically and quantitatively the metabolic activation of the carcinogen benzo(a)pyrene (BP) to a derivative which reacts covalently with a macromolecular target molecule (protein). The NADPH2-dependent formation of this macromolecule-hydrocarbon complex during incubation with rat liver ...
F B, Thomas, N B, Furlong
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Abstract A simple radioassay method is described to measure specifically and quantitatively the metabolic activation of the carcinogen benzo(a)pyrene (BP) to a derivative which reacts covalently with a macromolecular target molecule (protein). The NADPH2-dependent formation of this macromolecule-hydrocarbon complex during incubation with rat liver ...
F B, Thomas, N B, Furlong
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Benzo(a)pyrene diolepoxide-haemoglobin and albumin adducts at low levels of benzo(a)pyrene exposure
Biomarkers, 2000A biomonitoring study was conducted to simultaneously measure individual benzo(a)pyrene (BaP) exposure in 50 office employees, not occupationally exposed to polycyclic aromatic hydrocarbons (PAH), using personal samplers and the formation of (+) r-7, t-8-dihyroxy-t-9,t-10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) adducts to haemoglobin (BPDE-Hb ...
R. Pastorelli +7 more
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Biochemical Pharmacology, 1986
Previously reported inhibitors of benzo[a]pyrene (BaP) mutagenicity in Salmonella typhimurium strain TA98 were tested for their effectiveness against the mutagenicity of 6-methyl-benzo[a]pyrene (6-CH3-BaP), 6-hydroxymethyl-benzo[a]pyrene (6-CH2OH-BaP) and 6-acetoxymethyl-benzo[a]pyrene (6-CH3COOCH2-BaP). Dose-response curves obtained for phenothiazine (
J H, Bayless +3 more
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Previously reported inhibitors of benzo[a]pyrene (BaP) mutagenicity in Salmonella typhimurium strain TA98 were tested for their effectiveness against the mutagenicity of 6-methyl-benzo[a]pyrene (6-CH3-BaP), 6-hydroxymethyl-benzo[a]pyrene (6-CH2OH-BaP) and 6-acetoxymethyl-benzo[a]pyrene (6-CH3COOCH2-BaP). Dose-response curves obtained for phenothiazine (
J H, Bayless +3 more
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Radioimmunoassay for benzo[a]pyrene.
Journal of the National Cancer Institute, 1978A benzo[a]pyrene (BP)-bovine serum albumin conjugate was synthesized and used to immunize 2.5- to 3.0-kg New Zealand White rabbits. The resulting antisera to BP bound trace amounts of [3H] (55 pg; 6,000 counts/min). A radioimmunoassay (RIA) to BP was developed by the antiserum first being titered with the [3H]BP and then a standard curve being ...
N Y, Kado, E T, Wei
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Interacting mechanism of benzo(a)pyrene with free DNA in vitro
International Journal of Biological Macromolecules, 2021Junsheng Li +2 more
exaly