Results 281 to 290 of about 138,894 (338)
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Benzodiazepine Receptors

Clinical Neuropharmacology, 1983
It appeared recently that the important group of psychoactive drugs, the benzodiazepines, binds with high affinity to a single class of saturable sites on brain membranes of all higher vertebrates including man. There was a good correlation between the pharmacological effects of different benzodiazepines and their affinity for 3H-diazepam and 3H ...
C, Braestrup, M, Nielsen
openaire   +6 more sources

Benzodiazepine use in the United States.

JAMA psychiatry, 2015
IMPORTANCE Although concern exists regarding the rate of benzodiazepine use, especially long-term use by older adults, little information is available concerning patterns of benzodiazepine use in the United States.
M. Olfson, M. King, M. Schoenbaum
semanticscholar   +1 more source

Benzodiazepine use and cognitive decline in the elderly.

American Journal of Health-System Pharmacy, 2018
PURPOSE Published evidence on the relationship between benzodiazepine exposure and altered cognition in the geriatric population is reviewed. SUMMARY Benzodiazepines constitute one of the most commonly prescribed medication classes and are used ...
Jenna D Picton   +2 more
semanticscholar   +1 more source

The Benzodiazepine Story

Journal of Medicinal Chemistry, 1978
(1983). The Benzodiazepine Story. Journal of Psychoactive Drugs: Vol. 15, The Benzodiazepines. Two Decades of Research and Clinical Experience, pp. 15-17.
openaire   +7 more sources

BENZODIAZEPINES

International Anesthesiology Clinics, 1988
The structure of the GABAA receptor, through which GABA--the main inhibitory neurotransmitter in the mammalian CNS--produces its major synaptic effects, has recently been identified. The GABAA receptor is a member of a family of receptor-operated ion channels to which the nicotinic cholinergic receptor-cation channel and the glycine receptor-anion ...
openaire   +2 more sources

Benzodiazepine Use and Neuropsychiatric Outcomes in the ICU: A Systematic Review*

Critical Care Medicine, 2018
Objectives: A systematic assessment of the role of benzodiazepine use during ICU stay as a risk factor for neuropsychiatric outcomes during and after ICU admission. Data Sources: PubMed/Medline, EMBASE, The Cochrane Library, CINAHL, and PsychINFO.
L. Kok   +4 more
semanticscholar   +1 more source

Benzodiazepine dependence

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 1984
Dependence to benzodiazepines is difficult to induce in animals but has been induced by high doses in man. Case reports of benzodiazepine dependence are rare compared with the usage of these drugs, but provide no proper epidemiological framework for the estimation of risk.
openaire   +2 more sources

Benzodiazepines

2015
Benzodiazepines have been in clinical use since the 1960s. Benzodiazepines act through allosteric modulation of the GABAA receptor to enhance the activity of GABA, an inhibitory neurotransmitter, resulting in a slowing of neurotransmission and sedative and anxiolytic effects.
openaire   +2 more sources

Opioids and Benzodiazepines

Critical Care Clinics, 1995
Most patients in the intensive care unit experience pain and anxiety, which are treated most commonly with an opioid or a benzodiazepine. These compounds are effective and have a well-established safety record. With the exception of associated respiratory depression, they have a relatively wide therapeutic window.
Michael J. Murray   +2 more
openaire   +3 more sources

Benzodiazepines and behavior

Neuroscience & Biobehavioral Reviews, 1985
This article sets the background for the following series of articles on the behavioral actions of drugs acting at the GABA-benzodiazepine receptor complex. The articles provide detailed analyses of particular behaviors and emphasise the danger of interpreting all behavioral effects in terms of anxiety.
Steven J. Cooper, Sandra E. File
openaire   +3 more sources

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