Results 61 to 70 of about 158,750 (352)

Research on 1H NMR spectrum optimization of 2,3-benzodiazepines based on conformational isomerism

Results in Chemistry
To address the issue of multiple sets of signal peaks and irregular peak shapes in the 1H NMR spectra of some 2,3-benzodiazepines due to conformational isomerism, 1H NMR experiments were conducted using 2,3-benzodiazepines 1 as examples, with variations ...
Fei Zhang, Ya-Li Ding
doaj   +1 more source

Benzodiazepines and risk of all cause mortality in adults: cohort study

British medical journal, 2017
Objectives To evaluate the risk of all cause mortality associated with initiating compared with not initiating benzodiazepines in adults, and to address potential treatment barriers and confounding related to the use of a non-active comparator group ...
E. Patorno, R. Glynn, R. Levin, Moa P. Lee, K. Huybrechts   +4 more
semanticscholar   +1 more source

N‑Alkylation-Initiated Redox-Neutral [5 + 2] Annulation of 3‑Alkylindoles with o‑Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines

, 2019
Described herein is an unprecedented N-alkylation-initiated redox-neutral [5 + 2] annulation of 3-alkylindoles with o-aminobenzaldehydes via a cascade N-alkylation/dehydration/[1,5]-hydride transfer/Friedel–Crafts alkylation sequence.
Long-Fei Li (7525961), Jian Xiao (253329), Yao-Bin Shen (5746919), Qing Liu (20889), Liping Yu (339704), Shuai Wang (109515), Bin Qiu (1393390)   +6 more
core   +1 more source

Psychotropic medication use among community dwellers with and without Parkinson's disease – A nationwide cohort study

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims We studied the prevalence of psychotropic use and psychotropic polypharmacy in persons with Parkinson's disease (PD) during a 10‐year follow‐up, because longitudinal studies on this topic are scarce although non‐motor symptoms of PD are often treated with psychotropics.
Noora Nieminen, Anna‐Maija Tolppanen, Valtteri Kaasinen, Marjaana Koponen, Sirpa Hartikainen   +4 more
wiley   +1 more source

Impact of Benzodiazepines on Outcomes of Mechanically Ventilated Pediatric Intensive Care Patients: A Retrospective Cohort Study

Critical Care Explorations
IMPORTANCE:. Benzodiazepines are the most frequently used sedatives in PICUs, but they are increasingly associated with negative outcomes. Understanding their impact on patient outcomes is critical to provide better sedative management for patients ...
Amanda R. Kolmar, MD, Daniela Bravo, MD, Ricardo A. Fonseca, MD, Michael A. Kramer, MD, Jinli Wang, MA, Kristin P. Guilliams, MD, MSCI, Brian M. Fuller, MD, MSCI   +6 more
doaj   +1 more source

Balancing the Risks and Benefits of Benzodiazepines

, 2021
In September 2020, the US Food and Drug Administration (FDA) announced an anticipated update to the boxed warning on all benzodiazepines to explicitly “address the serious risks of abuse, addiction, physical dependence, and withdrawal reactions” among ...
Olfson, Mark, Kroenke, Kurt, Hirschtritt, Matthew E.   +2 more
core   +1 more source

Therapeutic drug monitoring of antimicrobials in a paediatric setting: A retrospective single‐centre study

British Journal of Clinical Pharmacology, EarlyView.
Aims Paediatric pharmacokinetics differ significantly from adults due to age‐related physiological changes, necessitating precise dose adjustments. However, data on therapeutic drug monitoring (TDM) implementation in paediatric setting remain limited.
Gianluca Gazzaniga, Stefano Agliardi, Riccardo Giossi, Alice Schianchi, Alessandra Romandini, Thomas Virdis, Silvia Nerini Molteni, Maria Luisa De Angelis, Stefania Paccagnini, Cecilia Gechtman, Alice Proto, Marco Fossati, Silvia Oliveri, Giulia Angela Pattarino, Elena Altieri, Agnese Graziosi, Arianna Pani, Romano Danesi, Stefano Martinelli, Costantino De Giacomo, Francesco Scaglione   +20 more
wiley   +1 more source

Benzodiazepines for delirium [PDF]

Cochrane Database of Systematic Reviews, 2009
Delirium occurs in 30% of hospitalised patients and is associated with prolonged hospital stay and increased morbidity and mortality. The results of uncontrolled studies have been unclear, with some suggesting that benzodiazepines may be useful in controlling non-alcohol related delirium.To determine the effectiveness and incidence of adverse effects ...
Edmund, Lonergan, Jay, Luxenberg, Almudena, Areosa Sastre   +2 more
openaire   +2 more sources

Increasing the reporting of adverse drug reaction‐related hospitalizations using an ICD‐10‐based identification workflow: A multicentre study from Switzerland

British Journal of Clinical Pharmacology, EarlyView.
Background Reporting adverse drug reactions (ADRs) is essential for drug safety. In Switzerland, healthcare professionals are legally required to report serious and unlabelled ADRs, yet under‐reporting remains widespread. We tested a novel method to increase reporting of ADR‐related hospitalizations.
Georgia Anita Weber, Sophie‐Charlotte Bartel, Michael Boch, Christoph Rosen, Michael Bodmer, Balthasar Luzius Hug, Thomas Stammschulte, Patrick E. Beeler   +7 more
wiley   +1 more source

Usos e efeitos dos benzodiazepínicos na visão de usuários [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Saúde Coletiva, Florianópolis, 2012Benzodiazepínicos podem gerar dependência.
Welter, Ana Carolina
core