Results 51 to 60 of about 97,224 (305)

Patient values and preferences regarding communicating risk versus benefit of benzodiazepine initiation: A cross‐sectional survey study

Health Science Reports, 2023
Background and Aims Communicating information about the risks and benefits of benzodiazepines so that it is meaningful to the patient has not been previously described.
Karn Chahal, Matthew Glass, Jamie Falk, Alexander Singer, Christine Leong   +4 more
doaj   +1 more source

Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea

Frontiers in Neuroscience, 2023
Glutamate and γ-aminobutyric acid (GABA) are the two main neurotransmitters in the human brain. The balance between their excitatory and inhibitory functions is crucial for maintaining the brain’s physiological functions.
Piotr Kaczmarski, Marcin Sochal, Dominik Strzelecki, Piotr Białasiewicz, Agata Gabryelska   +4 more
doaj   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

Impact of Benzodiazepines on Outcomes of Mechanically Ventilated Pediatric Intensive Care Patients: A Retrospective Cohort Study

Critical Care Explorations
IMPORTANCE:. Benzodiazepines are the most frequently used sedatives in PICUs, but they are increasingly associated with negative outcomes. Understanding their impact on patient outcomes is critical to provide better sedative management for patients ...
Amanda R. Kolmar, MD, Daniela Bravo, MD, Ricardo A. Fonseca, MD, Michael A. Kramer, MD, Jinli Wang, MA, Kristin P. Guilliams, MD, MSCI, Brian M. Fuller, MD, MSCI   +6 more
doaj   +1 more source

Prescription Trends in Complex Regional Pain Syndrome: A Retrospective Case–Control Study

Brain Sciences, 2023
Objective: The objective of this study was to evaluate discrepancies in prescription trends for analgesic medications in complex regional pain syndrome (CRPS) patients based on recommendations in the literature.
Suzanna Shermon, Kimberly M. Fazio, Richard Shim, Alaa Abd-Elsayed, Chong H. Kim   +4 more
doaj   +1 more source

Acute toxicity of ADB‐CHMINACA ‐ a case series of patients with pronounced central nervous symptoms including the posterior reversible encephalopathic syndrome

British Journal of Clinical Pharmacology, EarlyView.
Aim This report presents a series of 16 patients who were admitted to the emergency department following confirmed intake of the potent synthetic cannabinoid ADB‐CHMINACA. Methods The cases are drawn from a prospective observational study following the recreational use of synthetic cannabinoids.
Maren Hermanns‐Clausen, Michaela Sommer, Annette Zschiesche, Verena Angerer, Martin Scheu, Florian Eyer, Johannes Nadler, Volker Auwärter   +7 more
wiley   +1 more source

Saccadic eye velocity after selective GABAergic treatment with tiagabine in healthy volunteers [PDF]

, 2005
Background: Saccadic eye velocity (SEV) has been shown to be a reliable neurophysiological tool for the assessment of gamma-aminobutyric acid GABA(A) receptor sensitivity.
Zwanzger, P., Baghai, Thomas C., Ella, R., Rupprecht, R., Kathmann, N., Eser, D., Schule, C., Möller, Hans-Jürgen, Padberg, F.   +8 more
core   +2 more sources

Clozapine:norclozapine ratio as a marker of metabolic risk and therapeutic response and effect of valproate on clozapine levels

British Journal of Clinical Pharmacology, EarlyView.
Aims Clozapine is the most effective antipsychotic in treatment‐resistant schizophrenia. Clozapine causes weight gain and increased diabetes risk. The role of its metabolite norclozapine and clozapine:norclozapine ratio (CLZ/NCLZ) in metabolic effects has been debated.
Susanna Maria Rask, Miina Lamminmäki, Olli Kampman, Mari Hämäläinen, Eeva Moilanen, Niko Seppälä, Anssi Solismaa   +6 more
wiley   +1 more source

Research on 1H NMR spectrum optimization of 2,3-benzodiazepines based on conformational isomerism

Results in Chemistry
To address the issue of multiple sets of signal peaks and irregular peak shapes in the 1H NMR spectra of some 2,3-benzodiazepines due to conformational isomerism, 1H NMR experiments were conducted using 2,3-benzodiazepines 1 as examples, with variations ...
Fei Zhang, Ya-Li Ding
doaj   +1 more source

Investigating the role of benzodiazepines in drug-related mortality: A systematic review undertaken on behalf of The Scottish National Forum on Drug-Related Deaths [PDF]

, 2016
Owing to a lack of research on benzodiazepines, the National Forum on Drug-Related Deaths commissioned work addressing why benzodiazepines are common in DRDs and what role they play in such deaths, particularly at the high doses often reported.
Johnson, Chris F, Barnsdale, Lee R, McAuley, Andrew   +2 more
core