Results 41 to 50 of about 97,224 (305)
Natural Frequencies of Levodopa‐Induced Dyskinesia in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives Abnormal involuntary movements, known as dyskinesias, are common complications of levodopa treatment in patients with Parkinson's disease and can significantly impair quality of life. The underlying pathophysiology remains unclear, and current therapeutic options are limited.
Ioannis U. Isaias +3 more
wiley +1 more source
Case report on antipsychotic induced catatonia in an incarcerated patient
Frontiers in Psychiatry, 2023 Antipsychotic-induced catatonia is an iatrogenic and debilitating adverse reaction, but there is a dearth of recent documented cases. This report describes a 35-year-old incarcerated Korean-American male with a history of unspecified psychosis who ...
Han Nguyen +6 more
doaj +1 more source
Benzodiazepines in the Treatment of Behavioural and Psychological Symptoms Associated with Dementia and Their Impact on Cognitive Impairment: Review of Clinical Evidence [PDF]
, 2023 Alzheimer’s disease (AD) is the most common form of progressively disabling degenerative dementia. In dementia in general, there are, unfortunately, even from the earliest stages of the disease, associated behavioural and psychological symptoms of ...
Rosa Maria Cordaro, Pasqualina Stranieri
core +1 more source
Advanced Science, EarlyView.Hederagenin is identified as a GABAA1‐targeting natural compound that suppresses morphine‐associated reward by restraining Ca2+–CaMK–cAMP–CREB signaling in ventral tegmental dopaminergic neurons. RVG29‐modified liposomal delivery further enhances brain accumulation and behavioral efficacy, providing a mechanistically defined strategy for natural ...
Hongyang Jiang +15 more
wiley +1 more source
Benzodiazepine abuse among the elderly
Journal of Geriatric Mental Health, 2016 Benzodiazepines belong to the hypnotic-sedative class of drugs which have anxiolytic, sedative, and hypnotic properties. These drugs have been in clinical use for at least half a century.
Shalini Singh, Siddharth Sarkar
doaj +1 more source
Deprescribing opioids and benzodiazepines
, 2020 Benzodiazepines and opioids have long been known to have addictive properties. The increasingly high number of patients dependent on these medications may not be due only to their chemical properties.
Debbie Wilson
core +1 more source
Annals of Neurology, EarlyView.Objective Memory impairment is a frequent comorbidity of focal epilepsy, incompletely explained by seizure frequency or structural pathology. Ictal and postictal hippocampal dysfunction disrupt memory processes, but their cumulative impact remains poorly quantified.
Ionuț‐Flavius Bratu +5 more
wiley +1 more source
Social Listening of Benzodiazepines Abuse and Misuse
Emerging Trends in Drugs, Addictions, and HealthIntroduction: Benzodiazepines are Class C drugs that can act as anxiolytics, hypnotics, sedatives, and muscle relaxants. Over the decade, benzodiazepine misuse has proliferated with increasing numbers of newly emerging benzodiazepines.
A. Guirguis
doaj +1 more source
Autism Research, EarlyView.ABSTRACT Catatonia occurs disproportionately in autistic individuals and may respond to electroconvulsive therapy (ECT), yet prior reports suggest greater treatment burden in this population. We compared longitudinal ECT utilization, safety, and clinical outcomes between autistic and non‐autistic patients with catatonia.
Joshua Ryan Smith +15 more
wiley +1 more source
Zuranolone: A case study in (regulatory) rush to judgement?
British Journal of Clinical Pharmacology, EarlyView.Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove +4 more
wiley +1 more source