Results 41 to 50 of about 95,300 (255)

Patient values and preferences regarding communicating risk versus benefit of benzodiazepine initiation: A cross‐sectional survey study

Health Science Reports, 2023
Background and Aims Communicating information about the risks and benefits of benzodiazepines so that it is meaningful to the patient has not been previously described.
Karn Chahal, Matthew Glass, Jamie Falk, Alexander Singer, Christine Leong   +4 more
doaj   +1 more source

Influence of glutamatergic and GABAergic neurotransmission on obstructive sleep apnea

Frontiers in Neuroscience, 2023
Glutamate and γ-aminobutyric acid (GABA) are the two main neurotransmitters in the human brain. The balance between their excitatory and inhibitory functions is crucial for maintaining the brain’s physiological functions.
Piotr Kaczmarski, Marcin Sochal, Dominik Strzelecki, Piotr Białasiewicz, Agata Gabryelska   +4 more
doaj   +1 more source

Impact of Benzodiazepines on Outcomes of Mechanically Ventilated Pediatric Intensive Care Patients: A Retrospective Cohort Study

Critical Care Explorations
IMPORTANCE:. Benzodiazepines are the most frequently used sedatives in PICUs, but they are increasingly associated with negative outcomes. Understanding their impact on patient outcomes is critical to provide better sedative management for patients ...
Amanda R. Kolmar, MD, Daniela Bravo, MD, Ricardo A. Fonseca, MD, Michael A. Kramer, MD, Jinli Wang, MA, Kristin P. Guilliams, MD, MSCI, Brian M. Fuller, MD, MSCI   +6 more
doaj   +1 more source

Prescription Trends in Complex Regional Pain Syndrome: A Retrospective Case–Control Study

Brain Sciences, 2023
Objective: The objective of this study was to evaluate discrepancies in prescription trends for analgesic medications in complex regional pain syndrome (CRPS) patients based on recommendations in the literature.
Suzanna Shermon, Kimberly M. Fazio, Richard Shim, Alaa Abd-Elsayed, Chong H. Kim   +4 more
doaj   +1 more source

The effects of concurrent prescription of benzodiazepines for people undergoing opioid maintenance treatment: A systematic review [PDF]

, 2016
Background In Opioid Maintenance Treatment patients receive long acting opioids as a substitute for heroin and other common illegally used opioids. People with opioid dependence are likely to experience elevated levels of anxiety and sleep disturbance ...
Straumann, Gyri Synnøve Hval, Vist, Gunn Elisabeth, Ding, Yunpeng, Mosdøl, Annhild, Hov, Laila   +4 more
core  

Research on 1H NMR spectrum optimization of 2,3-benzodiazepines based on conformational isomerism

Results in Chemistry
To address the issue of multiple sets of signal peaks and irregular peak shapes in the 1H NMR spectra of some 2,3-benzodiazepines due to conformational isomerism, 1H NMR experiments were conducted using 2,3-benzodiazepines 1 as examples, with variations ...
Fei Zhang, Ya-Li Ding
doaj   +1 more source

Electroconvulsive Therapy for Catatonia in Autistic and Non‐Autistic Patients: An Observational Study on Course, Efficacy, Aggression, and Self‐Injury Outcomes

Autism Research, EarlyView.
ABSTRACT Catatonia occurs disproportionately in autistic individuals and may respond to electroconvulsive therapy (ECT), yet prior reports suggest greater treatment burden in this population. We compared longitudinal ECT utilization, safety, and clinical outcomes between autistic and non‐autistic patients with catatonia.
Joshua Ryan Smith, Maria Bonnee, Sarah Marler, Seri Lim, D. Catherine Fuchs, Rafael Tamargo, Isaac Baldwin, Christopher Maley, Ashley VanHaverbeck, Courtney Hamilton, Timothy Adegoke, Haozheng Xu, Jinyuan Liu, Zachary J. Williams, Jo Ellen Wilson, James Luccarelli   +15 more
wiley   +1 more source

Perspectives on drugs: The misuse of benzodiazepines among high-risk opioid users in Europe. [PDF]

, 2015
Benzodiazepines are a widely prescribed group of medicines with a range of clinical uses, including the treatment of anxiety and insomnia and the management of alcohol withdrawal.

core  

N‑Alkylation-Initiated Redox-Neutral [5 + 2] Annulation of 3‑Alkylindoles with o‑Aminobenzaldehydes: Access to Indole-1,2-Fused 1,4-Benzodiazepines

, 2019
Described herein is an unprecedented N-alkylation-initiated redox-neutral [5 + 2] annulation of 3-alkylindoles with o-aminobenzaldehydes via a cascade N-alkylation/dehydration/[1,5]-hydride transfer/Friedel–Crafts alkylation sequence.
Long-Fei Li (7525961), Jian Xiao (253329), Yao-Bin Shen (5746919), Qing Liu (20889), Liping Yu (339704), Shuai Wang (109515), Bin Qiu (1393390)   +6 more
core   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source