Results 41 to 50 of about 131,739 (305)

Trends in long-term prescribing of dependence forming medicines [PDF]

, 2019
Using patient-level primary care data to estimate the extent to which antidepressant medicines are prescribed to people continuously for long periods of time.
McManus, S., Nguyen, A., Sehmi, R., Smith, N.   +3 more
core  

Older adults and withdrawal from benzodiazepine hypnotics in general practice: effects on cognitive function, sleep, mood and quality of life [PDF]

, 2003
Background: Older adults are the main recipients of repeat prescriptions for benzodiazepine (BZD) hypnotics. BZDs can impair cognitive function and may not aid sleep when taken continuously for years.
Collins, R., Curran, H.V., Fletcher, S., Iliffe, S., Kee, S.C.Y., Woods, B.   +5 more
core   +1 more source

Prodromal Lewy Body Disorder Features in REM Sleep Behavior Disorder With Biomarker‐Defined Synucleinopathy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid eye movement sleep behavior disorder (iRBD) is a prodromal state for Lewy body disorders and exhibits biological heterogeneity that may influence clinical expression and progression. We examined clinical features in individuals with iRBD and biomarker‐defined synucleinopathy.
Daniel Weintraub, Michele K. York, Roseanne Dobkin, Anuprita R. Nair, Ryan Kurth, David‐Erick Lafontant, Chelsea Caspell‐Garcia, Roy N. Alcalay, Ethan G. Brown, Lana M. Chahine, Christopher Coffey, Tatiana Foroud, Douglas Galasko, Karl Kieburtz, Kenneth Marek, Kalpana Merchant, Brit Mollenhauer, Kathleen L. Poston, Andrew Siderowf, Cristina Simonet, Tanya Simuni, Caroline M. Tanner, Thomas F. Tropea, Aleksandar Videnovic, The Parkinson's Progression Markers Initiative   +24 more
wiley   +1 more source

An Update on the Synthesis of Pyrrolo[1,4]benzodiazepines

Molecules, 2016
Pyrrolo[1,4]benzodiazepines are tricyclic compounds that are considered “privileged structures” since they possess a wide range of biological activities.
George Varvounis
doaj   +1 more source

Effects of Clonidine versus Midazolam premedication on postoperative pain in patients undergoing elective spinal neurosurgery. Prospective randomized study [PDF]

Romanian Journal of Medical Practice, 2017
Many preoperative, intraoperative and postoperative interventions and management strategies are available and continue to evolve for reducing and managing postoperative pain.
Ana-Maria Cotae, Liliana Mirea, Raluca Ungureanu, Ioana Cristina Grintescu, Alexandra Ionescu, Oana Maria Melente, Ioana Marina Grintescu   +6 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

The Characteristics of Benzodiazepine Prescribing in the Republic of Srpska, Bosnia and Herzegovina

Medicina, 2022
Background and Objectives: Benzodiazepines (BZDs) are among the most prescribed psychotropic drugs and significant number of patients use these drugs for longer periods than recommended. The objective of this study was to determine the factors associated
Žana M. Maksimović, Mladen Stajić, Miloš P. Stojiljković, Svjetlana Stoisavljević Šatara, Nataša Stojaković, Ranko Škrbić   +5 more
doaj   +1 more source

Impact of Deprescribing Among Older Adults in Primary Care Settings: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials

AGING MEDICINE, EarlyView.
Deprescribing interventions in primary care modestly reduce medication burden, patient falls, and hospitalisations among older adults, highlighting the value of medication reviews and collaborative care strategies. ABSTRACT Background Deprescribing is a systematic approach aimed at reducing the number of medications that are no longer beneficial or ...
Christina Malini Christopher, Bhuvan KC, Mark Wing Loong Cheong, Rajeev Shrestha, Sunil Shrestha, Juman Dujaili, Ali Blebil   +6 more
wiley   +1 more source

Social Listening of Benzodiazepines Abuse and Misuse

Emerging Trends in Drugs, Addictions, and Health
Introduction: Benzodiazepines are Class C drugs that can act as anxiolytics, hypnotics, sedatives, and muscle relaxants. Over the decade, benzodiazepine misuse has proliferated with increasing numbers of newly emerging benzodiazepines.
A. Guirguis
doaj   +1 more source

Prediction of Drug–Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation

Drugs in R&D, 2019
Background Researchers have long been interested in the potential drug–drug interactions (DDIs) between opioids and benzodiazepines. However, much remains unknown concerning the interactions between these two drug classes.
Beihong Ji, Shuhan Liu, Ying Xue, Xibing He, Viet Hoang Man, Xiang-Qun Xie, Junmei Wang   +6 more
doaj   +1 more source