Results 31 to 40 of about 1,710 (123)

Cooperative Photocatalysis of 9,10‐Phenanthrenequinone and Sn(OTf)2 for Direct Mannich Reaction of Ethers via Hydrogen Atom Transfer Pathway

Advanced Synthesis &Catalysis, Volume 367, Issue 23, December 11, 2025.
A dual photocatalytic system of o‐PQ and Sn(OTf)2 enables visible light‐induced Mannich‐type addition of ethers to nitrones via Csp³–H activation. This oxidant‐free method offers broad scope and good yields. Mechanistic studies suggest that a photoexcited o‐PQ–Sn(II) complex mediates hydrogen atom transfer to form α‐oxy radicals for nitrone addition. A
Pradip Ramdas Thorve, Hun Young Kim, Kyungsoo Oh   +2 more
wiley   +1 more source

A Radical‐Based, Transition Metal‐Free Approach for Diaryl Ketone Synthesis

ChemSusChem, Volume 18, Issue 21, Novemebr 4, 2025.
A sustainable and scalable one‐pot route to diverse diaryl ketones is described, proceeding via a distinctive radical process between aryl halides and benzonitriles, initiated by KOtBu/DMA and driven by air as the sole oxidant. Free from transition metals, peroxides, and carbon monoxide, this catalyst‐free and selective method exhibits broad functional
Dongjie Wang, Jordan Garo, Yinpeng Wang, Jean‐Marc Sotiropoulos, Marc Taillefer   +4 more
wiley   +1 more source

6-Nitro-1,3-benzodioxole-4-carbaldehyde

Acta Crystallographica Section E Structure Reports Online, 2006
The title compound, C8H5NO5, consists of a cyclic diether (1,3-dioxalene) fused to 3-nitro­benzaldehyde. In the crystal structure, symmetry-related mol­ecules are linked by C—H⋯O hydrogen bonds, forming a sheet-like structure parallel to the ab plane. These sheets are further linked by C—H⋯O hydrogen bonds, forming a three-dimensional network.
Mukhtiar Hussain, Saqib Ali, Muhammad Altaf, Helen Stoeckli-Evans   +3 more
openaire   +1 more source

(S)-(−)-5,5′-Bis(diphenylphosphino)-4,4′-bi-1,3-benzodioxole [PDF]

Acta Crystallographica Section E Structure Reports Online, 2009
In the chiral title compound, C(38)H(28)O(4)P(2), the intra-molecular P⋯P separation is 3.671 (2) Å and the dihedral angle between the two benzene rings in the biphenyl unit is 77.9 (2)°.
Jian, Ling-Yan, He, Xiao-Jing, Sun, Ya-Xin, Jiang, Qing-Hua, Zhu, Xu   +4 more
openaire   +2 more sources

Synthesis and Anticancer Potential of New Benzimidazole Theranostic

ChemistryOpen, Volume 14, Issue 11, November 2025.
Recent advances have highlighted benzimidazole's importance in anticancer drug discovery. A novel series of benzimidazole analogs is designed and synthesized, with V7 showing broad anticancer activity and selectivity, possibly linked to SIRT2 inhibition.
Sahani Sandalima Uthumange, Muhammad Azri Faiz bin Abdul Zaki, Keng Yoon Yeong   +2 more
wiley   +1 more source

Mechanochemische Methoden mit Anwendung in der Late‐Stage Modifizierung Pharmazeutisch Wirksamer Verbindungen

Angewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley   +1 more source

2,2-Dimethyl-1,3-benzodioxol-4-ylN-methylcarbamate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2010
In the title compound, C(11)H(13)NO(4), the two fused rings are almost coplanar, making a dihedral angle of 3.02 (8)°. In the crystal, chains are formed parallel to [010] through N-H⋯O hydrogen bonds between the amine and carbonyl groups.
openaire   +3 more sources

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

Angewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Fragment‐Based Drug Discovery of Novel High‐affinity, Selective, and Anti‐inflammatory Inhibitors of the Keap1‐Nrf2 Protein‐Protein Interaction

Angewandte Chemie, Volume 137, Issue 39, September 22, 2025.
We developed potent and selective noncovalent Keap1‐Nrf2 inhibitors through a structure‐guided fragment‐based approach. These nanomolar inhibitors activate Nrf2‐controlled genes, suppress inflammation via NLRP3 and STING pathways, and exhibit distinct transcriptional profiles compared to covalent Nrf2 activators, offering promising chemical probes and ...
Chunyu Lin, Dilip Narayanan, Marilia Barreca, Cecilie Poulsen, Leandro Silva da Costa, Xiangrong Chen, Kendall G. Wichman, Cherisse A. Charley, Jaslin L. Lindsay, Mahya Dezfouli, Dimitra Vlissari, Thomas S. Mortensen, Camilla B. Chan, Jingyi Wang, William Richardson, Charlotte E. Manning, Zhuoyao Chen, Jie Zang, Helena Käck, Michael Gajhede, Alex N. Bullock, David J. Blake, David Olagnier, Anders Bach   +23 more
wiley   +1 more source

Ethyl 4-{5-[1-(hydroxymethyl)ethylaminocarbonyl]-1,3-benzodioxol-4-yl}-7-methoxy-3-benzodioxole-5-carboxylate

Acta Crystallographica Section E Structure Reports Online, 2006
In the title compound, C23H25NO10, the five-membered rings adopt envelope conformations and the dihedral angle between the two benzene rings is 67.1 (7)°. The crystal structure is stabilized by intramolecular N—H...O and intermolecular O—H...O hydrogen-bond interactions.
Xiu-Xiang Qi, Ji-Shuan Suo, Li-Min Wang, Xiao-He Guo, Sen-Xiang Cheng   +4 more
openaire   +1 more source