Results 41 to 50 of about 1,987 (185)

Structure‐Guided Optimization and Biological Validation of 1,3,4‐Thiadiazole‐Based SIRT2 Inhibitors Reinforcing Channel Entrance Interactions

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT SIRT2, the cytoplasmic member of the sirtuin family, is generally acknowledged to promote cancer and contribute to the progression of various pathologies, including neurodegeneration, inflammation, obesity, and bacterial infection through the deacetylation of target substrates.
Ahmet Bugra Aksel, Fikriye Ozgencil, Filiz Bakar‐Ates, Habibe Beyza Gunindi, Alberto Massarotti, Erva Ozkan, Selen Gozde Kaya, Mahmut Gozelle, Yesim Ozkan, Gokcen Eren   +9 more
wiley   +1 more source

1-(1,3-Benzodioxol-5-yl)butan-1-one [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
In the mol-ecule of the title compound, C(11)H(12)O(3), the dioxole ring adopts an envelope conformation. In the crystal structure, weak inter-molecular C-H⋯O hydrogen bonds link the mol-ecules into chains.
Wei Cheng, Ran Lv, Hong-Jun Zhu
openaire   +3 more sources

Uso de benzodioxolas em sistemas de fotoiniciação de adesivos odontológicos [PDF]

, 2009
The objective of this study was to evaluate the effectiveness of benzodioxole derivatives as co-initiators of radical polymerization of experimental self-etching adhesive systems.
Lima, Giana da Silveira
core  

Hexahydroquinoline Featuring Amide Functionality: A Promising Scaffold With Calcium Channel Blocking Activity

Drug Development Research, Volume 87, Issue 2, April 2026.
ABSTRACT Hexahydroquinoline (HHQ) is a widely recognized scaffold that has garnered considerable attention owing to its diverse pharmacological properties. The structure of HHQ includes a 1,4‐dihydropyridine (DHP) ring, which serves as the pharmacophore for the predominant class of drugs known as calcium channel blockers.
Ebru Koçak Aslan, Kevin Lam, Sun Huang, Göknil Pelin Coşkun, Ayşe Karagüzel, Katrin Denzinger, Kaan Birgül, Mert Ülgen, Jordan W. Nafie, Onur Şahin, Daniel W. Armstrong, Gerald W. Zamponi, Gerhard Wolber, Miyase Gözde Gündüz   +13 more
wiley   +1 more source

Selective Electrochemical sp3 CO Bond Hydrogenolysis: From Model Compounds to Lignin

ChemElectroChem, Volume 13, Issue 6, 17 March 2026.
Electrochemical sp3 CO bond cleavage is systematically investigated under constant‐current conditions using simple aryl ether models and extended to organosolv lignin. Controlled electron flow, regulated proton availability, and a sacrificial magnesium anode enable selective lignin depolymerization, yielding chemically distinct fractions with aromatic
Miquel Molina‐García, Antonio Doménech‐Carbó, Marta Mon, Antonio Leyva‐Pérez   +3 more
wiley   +1 more source

Combination of a UPO‐Based Epoxidation With a Subsequent Ring‐Opening Reaction for the Synthesis of Amino Alcohols

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
The synthesis of aromatic amino alcohols via a combination of an unspecific peroxygenase‐catalysed reaction, oxyfunctionalization, and addition of selected nucleophiles and electrophiles in a highly atom‐efficient manner was investigated. This study presents the design to aim for an atom‐efficient chemo‐enzymatic synthesis route towards aromatic amino ...
Simon Last, Niklas Dietz, Martin J. Weissenborn, Jan von Langermann   +3 more
wiley   +1 more source

Carbonylative Suzuki–Miyaura Coupling of 1‐Iodoglycals Mediated by the N‐Heterocyclic Carbene Catalyst PEPPSI: Preparation of C‐Acyl Glycosides

European Journal of Organic Chemistry, Volume 29, Issue 7, 23 February 2026.
A multicomponent carbonylative Suzuki–Miyaura reaction was developed for the synthesis of C‐acyl glycosides. Using Pyridine‐Enhanced Precatalyst Preparation, Stabilization, and Initiation (PEPPSI‐IPr) catalysis and Mo(CO)6 as a solid CO source, the reaction enables selective carbonylation of three components in synthetically useful yields, providing a ...
Eurípedes de Aguiar, Mônica F. Z. J. Toledo, Flávia Manarin, João H. de Araujo‐Neto, Milene M. Hornink, Hélio A. Stefani   +5 more
wiley   +1 more source

Expanding the Toolbox for Hydrogen Atom Transfer Catalysis: Sulfides as Structurally Diverse Catalysts Under Photoredox Conditions

Advanced Synthesis &Catalysis, Volume 368, Issue 4, 17 February 2026.
A new class of sulfide‐based catalysts for visible‐light‐driven hydrogen‐atom transfer (HAT) are reported. Single‐electron oxidation of alkyl aryl sulfides generates radical cations as the active HAT species whose catalytic activities are boosted by installing the 2‐thiazolyl structure.
Tetsuya Sengoku, Shun Nishioka, Yu Kokoda, Yoshifumi Noguchi, Toshiyasu Inuzuka   +4 more
wiley   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Emergence of Benzimidazole- and Strobilurin-Quinone Outside Inhibitor-Resistant Strains of Colletotrichum gloeosporioides sensu lato, the Causal Fungus of Japanese Pear Anthracnose, and Alternative Fungicides to Resistant Strains [PDF]

, 2019
Japanese pear anthracnose (JPA) can cause severe tree defoliation during the growing season. Infected trees become weak and produce fewer flower buds the following spring.
Ide, Youichi, Nita, Mizuho, Noguchi, Mayumi, Tashiro, Nobuya, Watanabe, Hisayoshi   +4 more
core   +2 more sources