Results 1 to 10 of about 17,747 (119)

Benzofuran-Annulated Naphthalimides Trigger Replication Stress, DNA Damage, and p53-Dependent Cell Cycle Arrest [PDF]

Pharmaceutics
Background/Objectives: DNA-targeting small molecules that induce replication stress represent a promising strategy in anticancer drug development.
Zlatina Vlahova, Lazar Lazarov, Maria Petrova, Shazie Yusein-Myashkova, Jordana Todorova, Maria Schröder, Monika Mutovska, Stanimir Stoyanov, Yulian Zagranyarski, Iva Ugrinova   +9 more
doaj   +2 more sources

An Exploration of the Inhibitory Mechanism of Rationally Screened Benzofuran-1,3,4-Oxadiazoles and-1,2,4-Triazoles as Inhibitors of NS5B RdRp Hepatitis C Virus through Pharmacoinformatic Approaches

Biomedicines, 2023
Benzofuran, 1,3,4-oxadiazole, and 1,2,4-triazole are privileged heterocyclic moieties that display the most promising and wide spectrum of biological activities against a wide variety of diseases. In the current study, benzofuran-1,3,4-oxadiazole BF1–BF7
Ali Irfan, Shah Faisal, Sajjad Ahmad, Muhammad Jawwad Saif, Ameer Fawad Zahoor, Samreen Gul Khan, Jamila Javid, Sami A. Al-Hussain, Muhammed Tilahun Muhammed, Magdi E. A. Zaki   +9 more
doaj   +1 more source

In Silico Development of Novel Benzofuran-1,3,4-Oxadiazoles as Lead Inhibitors of M. tuberculosis Polyketide Synthase 13

Pharmaceuticals, 2023
Benzofuran and 1,3,4-oxadiazole are privileged and versatile heterocyclic pharmacophores which display a broad spectrum of biological and pharmacological therapeutic potential against a wide variety of diseases.
Ali Irfan, Shah Faisal, Ameer Fawad Zahoor, Razia Noreen, Sami A. Al-Hussain, Burak Tuzun, Rakshanda Javaid, Ahmed A. Elhenawy, Magdi E. A. Zaki, Sajjad Ahmad, Magda H. Abdellattif   +10 more
doaj   +1 more source

Benzofuran as a promising scaffold for the synthesis of antimicrobial and antibreast cancer agents: A review

Journal of Research in Medical Sciences, 2015
Benzofuran as an important heterocyclic compound is extensively found in natural products as well as synthetic materials. Since benzofuran drivatives display a diverse array of pharmacological activities, an interest in developing new biologically active
Ghadamali Khodarahmi, Parvin Asadi, Farshid Hassanzadeh, Elham Khodarahmi   +3 more
doaj   +1 more source

A New Pathway for the Synthesis of a New Class of Blue Fluorescent Benzofuran Derivatives

Molecules, 2018
In this study an efficient and straightforward method for obtaining a new class of blue fluorescent bezofuran derivatives, under microwave irradiation, as well as under conventional thermal heating, is presented. Under conventional TH the reactions occur
Costel Moldoveanu, Ionel Mangalagiu, Dragos Lucian Isac, Anton Airinei, Gheorghita Zbancioc   +4 more
doaj   +1 more source

Synthesis of Elaborate Benzofuran-2-Carboxamide Derivatives through a Combination of 8-Aminoquinoline Directed C–H Arylation and Transamidation Chemistry

Molecules, 2020
Herein, we present a short and highly modular synthetic route that involves 8-aminoquinoline directed C−H arylation and transamidation chemistry, and which enables access to a wide range of elaborate benzofuran-2-carboxamides.
Michael Oschmann, Linus Johansson Holm, Monireh Pourghasemi-Lati, Oscar Verho   +3 more
doaj   +1 more source

Benzofuran Derivatives: Synthesis and Potential Therapeutic Role as VEGFR-2 Inhibitor [PDF]

Records of Pharmaceutical & Biomedical Sciences
Benzofuran is a crucial heterocyclic scaffold in medicinal chemistry, known for its occurrence in a wide array of naturally occurring and synthetically derived bioactive compounds.
Mohamed Shehda, Aya Almatary, Ranza Elrayess, Yasmine Abdel Aziz, Magda El-Sayed   +4 more
doaj   +1 more source

5-Iodo-2,7-dimethyl-3-phenylsulfinyl-1-benzofuran

Acta Crystallographica Section E, 2008
The title compound, C16H13IO2S, was prepared by the oxidation of 5-iodo-2,7-dimethyl-3-phenylsulfanyl-1-benzofuran using 3-chloroperbenzoic acid. The O atom and the phenyl group of the phenylsulfinyl substituent lie on opposite sides of the plane of the ...
Uk Lee, Byeng Wha Son, Pil Ja Seo, Hong Dae Choi   +3 more
doaj   +1 more source

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Frontiers in Chemistry, 2022
Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known ...
Yan Chen, Yan Chen, Guisheng Wang, Yilin Yuan, Ge Zou, Wencong Yang, Qi Tan, Wenyi Kang, Zhigang She   +8 more
doaj   +1 more source

Synthesis of Benzofuran Derivatives via Rearrangement and Their Inhibitory Activity on Acetylcholinesterase

Molecules, 2010
During a synthesis of coumarins to obtain new candidates for treating Alzheimer’s Disease (AD), an unusual rearrangement of a benzopyran group to a benzofuran group occurred, offering a novel synthesis pathway of these benzofuran derivatives.
Ling-Yi Kong, Tao Wang, Xiao-Bing Wang, Miao Li, Xiang Zhou   +4 more
doaj   +1 more source