Results 1 to 10 of about 17,147 (167)

An Exploration of the Inhibitory Mechanism of Rationally Screened Benzofuran-1,3,4-Oxadiazoles and-1,2,4-Triazoles as Inhibitors of NS5B RdRp Hepatitis C Virus through Pharmacoinformatic Approaches

Biomedicines, 2023
Benzofuran, 1,3,4-oxadiazole, and 1,2,4-triazole are privileged heterocyclic moieties that display the most promising and wide spectrum of biological activities against a wide variety of diseases. In the current study, benzofuran-1,3,4-oxadiazole BF1–BF7
Ali Irfan, Shah Faisal, Sajjad Ahmad, Muhammad Jawwad Saif, Ameer Fawad Zahoor, Samreen Gul Khan, Jamila Javid, Sami A. Al-Hussain, Muhammed Tilahun Muhammed, Magdi E. A. Zaki   +9 more
doaj   +1 more source

Benzofuran derivatives and the thyroid [PDF]

Clinical Endocrinology, 2008
SummaryAmiodarone and dronedarone are two clinically important benzofuran derivatives. Amiodarone has been used widely for treating resistant tachyarrhythmias in the past three decades. However amiodarone and its main metabolically active metabolite desethylamiodarone can adversely affect many organs, including the thyroid gland.
T S, Han, G R, Williams, M P J, Vanderpump   +2 more
openaire   +2 more sources

In Silico Development of Novel Benzofuran-1,3,4-Oxadiazoles as Lead Inhibitors of M. tuberculosis Polyketide Synthase 13

Pharmaceuticals, 2023
Benzofuran and 1,3,4-oxadiazole are privileged and versatile heterocyclic pharmacophores which display a broad spectrum of biological and pharmacological therapeutic potential against a wide variety of diseases.
Ali Irfan, Shah Faisal, Ameer Fawad Zahoor, Razia Noreen, Sami A. Al-Hussain, Burak Tuzun, Rakshanda Javaid, Ahmed A. Elhenawy, Magdi E. A. Zaki, Sajjad Ahmad, Magda H. Abdellattif   +10 more
doaj   +1 more source

Benzofuran Derivatives. I. On the Effects of Substituents in Benzofuran Syntheses [PDF]

Bulletin of the Chemical Society of Japan, 1983
Abstract The Rössing’s reaction of 4-substituted 2-acylphenoxyacetic acids give a mixture of benzofurans and 2-benzofurancarboxylic acids. The relative yields of benzofurans and 2-benzofurancarboxylic acids depend on the substituents on the benzene ring of the 2-acylphenoxyacetic acids.
Tsuneo Suzuki, Takaaki Horaguchi, Takahachi Shimizu, Teishiro Abe   +3 more
openaire   +1 more source

Benzofuran as a promising scaffold for the synthesis of antimicrobial and antibreast cancer agents: A review

Journal of Research in Medical Sciences, 2015
Benzofuran as an important heterocyclic compound is extensively found in natural products as well as synthetic materials. Since benzofuran drivatives display a diverse array of pharmacological activities, an interest in developing new biologically active
Ghadamali Khodarahmi, Parvin Asadi, Farshid Hassanzadeh, Elham Khodarahmi   +3 more
doaj   +1 more source

A New Pathway for the Synthesis of a New Class of Blue Fluorescent Benzofuran Derivatives

Molecules, 2018
In this study an efficient and straightforward method for obtaining a new class of blue fluorescent bezofuran derivatives, under microwave irradiation, as well as under conventional thermal heating, is presented. Under conventional TH the reactions occur
Costel Moldoveanu, Ionel Mangalagiu, Dragos Lucian Isac, Anton Airinei, Gheorghita Zbancioc   +4 more
doaj   +1 more source

Benzofuran Derivatives: Synthesis and Potential Therapeutic Role as VEGFR-2 Inhibitor [PDF]

Records of Pharmaceutical & Biomedical Sciences
Benzofuran is a crucial heterocyclic scaffold in medicinal chemistry, known for its occurrence in a wide array of naturally occurring and synthetically derived bioactive compounds.
Mohamed Shehda, Aya Almatary, Ranza Elrayess, Yasmine Abdel Aziz, Magda El-Sayed   +4 more
doaj   +1 more source

Synthesis of Elaborate Benzofuran-2-Carboxamide Derivatives through a Combination of 8-Aminoquinoline Directed C–H Arylation and Transamidation Chemistry

Molecules, 2020
Herein, we present a short and highly modular synthetic route that involves 8-aminoquinoline directed C−H arylation and transamidation chemistry, and which enables access to a wide range of elaborate benzofuran-2-carboxamides.
Michael Oschmann, Linus Johansson Holm, Monireh Pourghasemi-Lati, Oscar Verho   +3 more
doaj   +1 more source

Metabolites With Cytotoxic Activities From the Mangrove Endophytic Fungus Fusarium sp. 2ST2

Frontiers in Chemistry, 2022
Two new 3-decalinoyltetramic acid derivatives with peroxide bridge fusarisetins E (1) and F (2), one new chromone fusarimone A (5), two new benzofurans fusarifurans A (9) and B (10), three new isocoumarins fusarimarins A–C (11–13), as well as five known ...
Yan Chen, Yan Chen, Guisheng Wang, Yilin Yuan, Ge Zou, Wencong Yang, Qi Tan, Wenyi Kang, Zhigang She   +8 more
doaj   +1 more source

5-Iodo-2,7-dimethyl-3-phenylsulfinyl-1-benzofuran

Acta Crystallographica Section E, 2008
The title compound, C16H13IO2S, was prepared by the oxidation of 5-iodo-2,7-dimethyl-3-phenylsulfanyl-1-benzofuran using 3-chloroperbenzoic acid. The O atom and the phenyl group of the phenylsulfinyl substituent lie on opposite sides of the plane of the ...
Uk Lee, Byeng Wha Son, Pil Ja Seo, Hong Dae Choi   +3 more
doaj   +1 more source