Results 21 to 30 of about 17,790 (155)
2-Methyl-5,6-methylenedioxy-3-phenylsulfonyl-1-benzofuran
Acta Crystallographica Section E, 2008 The title compound, C16H12O5S, was prepared by oxidation of 2-methyl-5,6-methylenedioxy-3-phenylsulfanyl-1-benzofuran with 3-chloroperoxybenzoic acid.
Uk Lee +3 more
doaj +1 more source
KAT6A-inhibitor co-crystal structures: tackling a challenging crystallization target via two alternative approaches. [PDF]
Acta Crystallogr D Struct BiolWe report a novel cysteine‐to‐serine surface‐mutation approach to determine co‐crystal structures of KAT6A with small‐molecule inhibitors and compare it with the previously published MYSTcryst approach which uses mutated KAT8 as a surrogate for KAT6A.
Puetter V +8 more
europepmc +2 more sources
5-Fluoro-2-(4-iodophenyl)-3-methylsulfinyl-1-benzofuran
Acta Crystallographica Section E, 2009 In the title compound, C15H10FIO2S, the O atom and the methyl group of the methylsulfinyl substituent lie on opposite sides of the plane through the benzofuran fragment.
Hong Dae Choi +3 more
doaj +1 more source
2-(4-Fluorophenyl)-3-methylsulfanyl-5-phenyl-1-benzofuran
Acta Crystallographica Section E, 2009 In the title compound, C21H15FOS, the 4-fluorophenyl ring is rotated out of the benzofuran plane, making a dihedral angle of 24.3 (1)°. The dihedral angle between the phenyl ring and the benzofuran plane is 28.3 (1)°.
Hong Dae Choi +3 more
doaj +1 more source
Enhancement of Dissymmetry Factors Through Axial Elongation of Hetero[n]helicenes
Angewandte Chemie, EarlyView.A benzofuran scaffolding strategy enables the synthesis of hetero[9]‐, [12]‐, and [15]helicenes. Structural and chiroptical analyses demonstrate that systematic axial elongation increases helical distortion and significantly amplifies luminescence dissymmetry.
Jeppe S. Mogensen +7 more
wiley +2 more sources
Crystal structure of diethyl (E)-2-[(benzofuran-2-yl)methylidene]succinate
Acta Crystallographica Section E: Crystallographic Communications, 2015 The title compound, C17H18O5, was synthesized by a base-free catalytic Wittig reaction. The molecule consists of a diethyl itaconate unit, which is connected via the C=C double bond to a benzofuran moiety. The benzofuran ring system (r.m.s. deviation = 0.
Marie-Luis Schirmer +2 more
doaj +1 more source
Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +2 more sources
3-Methylsulfinyl-2-phenyl-1-benzofuran
Acta Crystallographica Section E, 2008 The title compound, C15H12O2S, was prepared by the oxidation of 3-methylsulfanyl-2-phenyl-1-benzofuran with 3-chloroperoxybenzoic acid. The phenyl ring makes a dihedral angle of 37.65 (8)° with the plane of the benzofuran fragment.
Uk Lee +3 more
doaj +1 more source
Angewandte Chemie, EarlyView.The use of 1,1,3,3‐tetramethyldisiloxane (TMDSO) and potassium tert‐butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studies support the formation of a substrate‐associated hydride‐like base, providing a single‐step alternative to the classical deprotonation and electrophile ...
Piers St. Onge +4 more
wiley +2 more sources
Bioresources and Bioprocessing, 2018 Background Benzofuran and its derivatives contain central pharmacophores and are important structures in medicinal chemistry. Chemical synthesis of benzofuran rings often requires expensive catalysts and stringent operational conditions.
Xin Liu +6 more
doaj +1 more source