Results 61 to 70 of about 30,052 (209)
Structure-activity relationships for analogs of the tuberculosis drug bedaquiline with the naphthalene unit replaced by bicyclic heterocycles [PDF]
, 2018 Replacing the naphthalene C-unit of the anti-tuberculosis drug bedaquiline with a range of bicyclic heterocycles of widely differing lipophilicity gave analogs with a 4.5-fold range in clogP values.
Blaser, A +10 more
core +1 more source
ChemistryOpen, EarlyView.In organic synthesis, deep eutectic solvents (DES) have demonstrated their ability to be used as reaction media for the development of reactions in line with green chemistry principles. This review presents an overview of microwave‐assisted organic synthesis in DES, highlighting the diversity of uses for these solvents, their role in mechanisms, the ...
Pierre‐Olivier Delaye +2 more
wiley +1 more source
Pharmacological profile of novel psychoactive benzofurans [PDF]
, 2015 Benzofurans are newly used psychoactive substances, but their pharmacology is unknown. The aim of the present study was to pharmacologically characterize benzofurans in vitro.; We assessed the effects of the benzofurans 5-APB, 5-APDB, 6-APB, 6-APDB, 4 ...
Hoener, Marius C. +3 more
core +1 more source
Climate change‐driven expansion of goosegrass highlights risks to global food production
Pest Management Science, EarlyView.Climate change is expanding the climatic suitability of Eleusine indica into temperate agricultural regions, increasing its overlap with major soybean and maize production areas. These findings highlight a growing global threat to food security and the need for proactive weed management strategies.
Thiago Deomar Ludwig +4 more
wiley +1 more source
Ultrasound Mediated, Green Innovation for the Synthesis of Polysubstituted 1,4-Dihydropyridines [PDF]
, 2016 An elegant, atom efficient protocol via a one-pot four-component cyclocondensation reaction of aromatic aldehydes, malononitrile, acetylenedicarboxylates and arylamines catalyzed by copper(i) iodide in aqueous medium under ultrasound irradiation has been
Pasha, M.A. +3 more
core +1 more source
Design, synthesis and evaluation of benzofuran-acetamide scaffold as potential anticonvulsant agent
Acta Pharmaceutica, 2016 A series of N-(2-(benzoyl/4-chlorobenzoyl)-benzofuran- 3-yl)-2-(substituted)-acetamide derivatives (4a-l, 5a-l) was synthesized in good yield. All synthesized compounds were in agreement with elemental and spectral data.
Shakya Ashok K. +6 more
doaj +1 more source
Crystal structure of 2,5-dimethyl-3-(2-methylphenylsulfonyl)-1-benzofuran
Acta Crystallographica Section E, 2014 The title compound, C17H16O3S, crystallized with two independent molecules (A and B) in the asymmetric unit. The dihedral angle between the benzofuran ring system [r.m.s.
Hong Dae Choi, Uk Lee
doaj +1 more source
Metal‐Free Electrophilic Borylative Cyclizations of Alkynes
The Chemical Record, EarlyView.Metal‐free borylative cyclizations based on electrophilic alkyne activation by boron Lewis acids provide efficient access to borylated hetero‐ and carbocycles. Early studies using B(C6F5)3 displayed limited scope and application, whereas recent ClBcat‐ and BCl3‐based methods enable mild CB and CC/CX bond formation for the synthesis of cycles ...
Jaime Mateos‐Gil +3 more
wiley +1 more source
Quantitative surface field analysis: learning causal models to predict ligand binding affinity and pose. [PDF]
, 2018 We introduce the QuanSA method for inducing physically meaningful field-based models of ligand binding pockets based on structure-activity data alone. The method is closely related to the QMOD approach, substituting a learned scoring field for a pocket ...
Cleves, Ann E, Jain, Ajay N
core
2-(4,6-Dimethyl-1-benzofuran-3-yl)acetic acid
IUCrData, 2016 In the title compound, C12H12O3, the dihedral angle between the planes of the carboxylic acid group and the benzofuran ring system (r.m.s. deviation = 0.012 Å) is 76.53 (10)°.
N. Ramprasad +3 more
doaj +1 more source