Results 71 to 80 of about 30,744 (240)

Ivermectin binding sites in human and invertebrate Cys-loop receptors [PDF]

, 2012
Ivermectin is a gold standard antiparasitic drug that has been used successfully to treat billions of humans, livestock and pets. Until recently, the binding site on its Cys-loop receptor target had been a mystery. Recent protein crystal structures, site-
Lynagh, Timothy, Lynch, Joseph W.
core   +1 more source

Fluorene‐based blue emitters: On the path to electrically pumped organic lasers

FlexMat, EarlyView.
Electrically pumped efficient operation remains unrealized, a major challenge in optoelectronics. Fluorene‐based blue‐emitting semiconductors are promising gain media, thanks to their structural tunability and favorable emission properties. This review summarizes recent advances, highlights their reliability and versatility in lasing, and outlines key ...
Yong Yan, Hao Li, Mengna Yu, Huiyin Wang, Jiangqiang He, Menghan Wu, Quanyou Feng, Linghai Xie   +7 more
wiley   +1 more source

Crystal structure of 5-bromo-2,4,6-trimethyl-3-[(2-methylphenyl)sulfinyl]-1-benzofuran

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C18H17BrO2S, the dihedral angle between the mean planes of the benzofuran [r.m.s. deviation = 0.025 (2) Å] and the 2-methylbenzene rings is 87.87 (5)°.
Hong Dae Choi, Uk Lee
doaj   +1 more source

Oxo-aglaiastatin-mediated inhibition of translation initiation [PDF]

, 2019
We thank Dr. Elias George (McGill University) for the kind gift of Pgp-1-expressing HeLa cells. RIM was supported by a doctoral fellowship from the Cole Foundation.
Brown, Lauren E., Cencic, Regina, Chu, Jennifer, Devine, William G., Maiga, Rayelle Itoua, Pelletier, Jerry, Porco, John A., Sebag, Michael, Waller, Daniel D., Zhang, Wenhan   +9 more
core   +2 more sources

Effects of catechins, resveratrol, silymarin components and some of their conjugates on xanthine oxidase‐catalyzed xanthine and 6‐mercaptopurine oxidation

Journal of the Science of Food and Agriculture, Volume 105, Issue 5, Page 2765-2776, 30 March 2025.
Abstract BACKGROUND Over the past two decades, the global incidence of gout has markedly increased, affecting people worldwide. Considering the side effects of xanthine oxidase (XO) inhibitor drugs (e.g. allopurinol and febuxostat) used in the treatment of hyperuricemia and gout, the potential application of phytochemicals has been widely studied.
Tímea Bencsik, Orsolya Balázs, Róbert G Vida, Balázs Z Zsidó, Csaba Hetényi, Kateřina Valentová, Miklós Poór   +6 more
wiley   +1 more source

A New Benzofuran Glycoside and Indole Alkaloids from a Sponge-Associated Rare Actinomycete, Amycolatopsis sp.

Marine Drugs, 2014
Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp.
Yun Kwon, Seong-Hwan Kim, Yoonho Shin, Munhyung Bae, Byung-Yong Kim, Sang Kook Lee, Ki-Bong Oh, Jongheon Shin, Dong-Chan Oh   +8 more
doaj   +1 more source

Identification of G-quadruplex DNA/RNA binders: Structure-based virtual screening and biophysical characterization [PDF]

, 2017
Background Recent findings demonstrated that, in mammalian cells, telomere DNA (Tel) is transcribed into telomeric repeat-containing RNA (TERRA), which is involved in fundamental biological processes, thus representing a promising anticancer target. For
Alcaro, Stefano, Artese, Anna, Costa, Giosu\ue8, Distinto, Simona, Maccioni, Elias, Moraca, Federica, Nadai, Matteo, Ortuso, Francesco, Richter, Sara, Rocca, Roberta, Scalabrin, Matteo, Talarico, Carmine   +11 more
core   +1 more source

High‐Efficiency and Long‐Lifetime Narrowband Green MR‐TADF OLEDs Enabled by Distinct Molecular Design Strategies

Journal of the Society for Information Display, EarlyView.
Two complementary molecular design strategies are proposed to independently enhance operational stability and device efficiency in MR‐TADF OLEDs. Strengthening the cationic bond dissociation energy (BDEf+) improves intrinsic molecular robustness and prolongs device lifetime, although a PSF‐based efficiency‐oriented design with high molar absorption ...
Hai Truyen Dang, Eo Jin Jeon, Thi Thuy Truong, Nikita Abitkar, Jang Hyuk Kwon   +4 more
wiley   +1 more source

Crystal structure of vilazodone hydrochloride methanol monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the title compound, C26H28N5O2+·Cl−·CH3OH {systematic name: 4-(2-carbamoyl-1-benzofuran-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring
Xiu-Rong Hu, Jia-Li Ye, Jian-Ming Gu
doaj   +1 more source

Synthesis of C,N'-linked bis-heterocycles using a deprotometalation-iodination-N-arylation sequence and evaluation of their antiproliferative activity in melanoma cells [PDF]

, 2014
International audienceBenzothiophene, benzofuran, benzothiazole and benzoxazole were deprotometalated using the lithium-zinc combination prepared from ZnCl2*TMEDA (TMEDA = N,N,N',N'-tetramethylethylenediamine, 1 equiv) and lithium 2,2,6,6 ...
Bentabed-Ababsa, Ghenia, Chevallier, Floris, Derdour, Aicha, Dorcet, Vincent, Florence, Mongin, Hedidi, Madani, Picot, Laurent, Roisnel, Thierry, Thiery, Valérie   +8 more
core   +3 more sources