Design, synthesis and evaluation of benzofuran-acetamide scaffold as potential anticonvulsant agent
Acta Pharmaceutica, 2016 A series of N-(2-(benzoyl/4-chlorobenzoyl)-benzofuran- 3-yl)-2-(substituted)-acetamide derivatives (4a-l, 5a-l) was synthesized in good yield. All synthesized compounds were in agreement with elemental and spectral data.
Shakya Ashok K. +6 more
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Crystal structure of 2,5-dimethyl-3-(2-methylphenylsulfonyl)-1-benzofuran
Acta Crystallographica Section E, 2014 The title compound, C17H16O3S, crystallized with two independent molecules (A and B) in the asymmetric unit. The dihedral angle between the benzofuran ring system [r.m.s.
Hong Dae Choi, Uk Lee
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Quantitative surface field analysis: learning causal models to predict ligand binding affinity and pose. [PDF]
, 2018 We introduce the QuanSA method for inducing physically meaningful field-based models of ligand binding pockets based on structure-activity data alone. The method is closely related to the QMOD approach, substituting a learned scoring field for a pocket ...
Cleves, Ann E, Jain, Ajay N
core
Identification of A Novel Class of Benzofuran Oxoacetic Acid-Derived Ligands that Selectively Activate Cellular EPAC1 [PDF]
, 2019 Cyclic AMP promotes EPAC1 and EPAC2 activation through direct binding to a specific cyclic nucleotide-binding domain (CNBD) within each protein, leading to activation of Rap GTPases, which control multiple cell responses, including cell proliferation ...
Barker, Graeme +20 more
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Emerging Trends in Organic Photoreactions Utilizing Disulfides
European Journal of Organic Chemistry, EarlyView.Disulfides are versatile, nontoxic alternatives to metal photocatalysts. This review explores their role as photoactivated thiyl‐radical precursors and bifunctional catalysts (HAT/electron shuttling) in diverse transformations. Strategies for electronic tuning and development into recyclable heterogeneous materials are highlighted for sustainable ...
Sunil Kumar +3 more
wiley +1 more source
2-(4,6-Dimethyl-1-benzofuran-3-yl)acetic acid
IUCrData, 2016 In the title compound, C12H12O3, the dihedral angle between the planes of the carboxylic acid group and the benzofuran ring system (r.m.s. deviation = 0.012 Å) is 76.53 (10)°.
N. Ramprasad +3 more
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Synthesis and photochromic properties of benzofuran–phenanthrene and benzofuran–pyrene hybrids
RSC Adv., 2014 Iron(iii) chloride mediated condensation of phenanthrene-9,10-dione and pyrene-4,5-dione with cyclohexanone and its derivatives furnish benzofuran–phenanthrene and benzofuran–pyrene hybrids.
H. Surya Prakash Rao, Satish Vijjapu
openaire +1 more source
European Journal of Organic Chemistry, EarlyView.A microwave‐enhanced sustainable and versatile approach to substituted benzofurans from 2‐alkynylanisoles enabled by an active Brønsted acidic deep eutectic solvent. The research on alternative media for organic transformations remains a highly demanding topic.
Alessandra Gritti +9 more
wiley +1 more source
Combined in vitro and in silico approaches to the assessment of stimulant properties of novel psychoactive substances – The case of the benzofuran 5-MAPB [PDF]
, 2016 Novel psychoactive substances (NPS) are increasingly prevalent world-wide although their pharmacological characteristics are largely unknown; those with stimulant properties, due to interactions with the dopamine transporter (DAT), have addictive ...
Beuming +49 more
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Remarkable Formation of Indene Derivatives Upon Friedel–Crafts Acylation Reactions
European Journal of Organic Chemistry, EarlyView.This shows indene derivatives. Under the reaction conditions of a Friedel–Crafts acylation, alkyl benzenes underwent an unprecedented cyclopentannulation furnishing indene derivatives. Alkylbenzene derivatives react with two equivalents of pivaloyl chloride (PivCl) in the presence of aluminum trichloride under formation of indene derivatives with up to
Leah Bantel +3 more
wiley +1 more source