Synthesis and photochromic properties of benzofuran–phenanthrene and benzofuran–pyrene hybrids
RSC Adv., 2014 Iron(iii) chloride mediated condensation of phenanthrene-9,10-dione and pyrene-4,5-dione with cyclohexanone and its derivatives furnish benzofuran–phenanthrene and benzofuran–pyrene hybrids.
H. Surya Prakash Rao, Satish Vijjapu
openaire +1 more source
Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt
British Journal of Pharmacology, EarlyView.Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown +2 more
wiley +1 more source
Plant Biology, EarlyView.Potassium silicate can decrease the uptake of sodium (Na+) into wheat cells by affecting the Na+ uptake channels and increasing ion homeostasis. Abstract Salinity causes negative impacts on crops. We investigated the effect of potassium silicate (K2SiO3) on the cytosolic uptake of sodium, [Na+]cyt, in mesophyll protoplasts of wheat cultivars differing ...
M. T. Javed, S. H. Morgan, S. Lindberg
wiley +1 more source
Inter- and intramolecular Diels-Alder/retro-Diels-Alder reactions of 4-silylated oxazoles [PDF]
, 2002 4-Silylated oxazoles have been shown to undergo inter- and intramolecular Diels-Alder/retro-Diels-Alder reactions with electron-poor alkynes to generate polysubstituted furans.
Ducept, P.C., Marsden, S.P.
core +1 more source
Stereoselective Synthesis of 2-(2-Aminoalkyl)- and 1,3-Disubstituted Tetrahydro-1H-pyrido[4,3-b]- Benzofuran and Indole Derivatives [PDF]
, 2016 The addition of an allenyl indium intermediate to chiral N-tert-butanesulfinyl imines 7 proceeds with high levels of diastereocontrol. The resulting homopropargylic amine derivatives 10 were transformed into 2-(2-aminoalkyl)benzofuran and indole ...
Foubelo, Francisco +2 more
core +3 more sources
Crystal structure of 5-bromo-2,4,6-trimethyl-3-[(2-methylphenyl)sulfinyl]-1-benzofuran
Acta Crystallographica Section E: Crystallographic Communications, 2015 In the title compound, C18H17BrO2S, the dihedral angle between the mean planes of the benzofuran [r.m.s. deviation = 0.025 (2) Å] and the 2-methylbenzene rings is 87.87 (5)°.
Hong Dae Choi, Uk Lee
doaj +1 more source
Ligand-Free Palladium-Catalyzed Oxyarylation of Dihydronaphthalenes and Chromenequinone with o-Iodophenols and 3-Iodolawsone in PEG-400: An Efficient Synthesis of 5-Carbapterocarpans and Pterocarpanquinones [PDF]
, 2015 Dihydronaphthalenes were oxyarylated with o-iodophenols, in PEG-400 at 140 or 170 °C, leading regio- and stereoselectively to 5-carbapterocarpans. By using Pd(OAc)2 (5–10 mol%) as precatalyst and Ag2CO3 (1.1 equiv) as base (conditions A), products were ...
Borges, Rackel H.F. +6 more
core +2 more sources
Marine Drugs, 2014 Three new secondary metabolites, amycofuran (1), amycocyclopiazonic acid (2), and amycolactam (3), were isolated from the sponge-associated rare actinomycete Amycolatopsis sp.
Yun Kwon +8 more
doaj +1 more source
Molecular Glue Degraders Redefining Targeted Therapies From Discovery to Therapeutic Applications
MedComm – Oncology, Volume 5, Issue 1, March 2026.Molecular glue degraders (MGDs) constitute an emerging class of therapeutic agents poised to revolutionize the paradigm of targeted drug discovery. By reprogramming E3 ubiquitin ligases to degrade proteins of interest (POI) via a transient formation of a ternary complex mediated by protein–protein interactions, MGDs surpass the intrinsic limitations of
Jinfeng Wen +3 more
wiley +1 more source
Crystal structure of vilazodone hydrochloride methanol monosolvate
Acta Crystallographica Section E: Crystallographic Communications, 2016 In the title compound, C26H28N5O2+·Cl−·CH3OH {systematic name: 4-(2-carbamoyl-1-benzofuran-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring
Xiu-Rong Hu, Jia-Li Ye, Jian-Ming Gu
doaj +1 more source