Results 111 to 120 of about 124,782 (320)

Isothiourea‐Catalysed Acylative Kinetic and Dynamic Kinetic Resolution of Planar Chiral Paracyclophanols

Angewandte Chemie, EarlyView.
The highly selective acylative (dynamic) kinetic resolution of racemic paracyclophanols catalysed by a chiral isothiourea (5 mol%) is described (up to s = 50 at 49% conversion or up to 98:2 er and 96% yield in 30 examples). Rotational barriers were analysed for paracyclophanols and selected ester products.
Zhanyu Zhou, Kevin Kasten, Aidan P. McKay, David B. Cordes, Andrew D. Smith   +4 more
wiley   +2 more sources

Supramolecular chemistry with ureido-benzoic acids

Chem. Sci., 2014
A novel, complementary quadruple hydrogen-bonding motif is presented that shows very strong dimerization and is switchable with pH.
Wilco P. J. Appel, Marko M. L. Nieuwenhuizen, Martin Lutz, Bas F. M. de Waal, Anja R. A. Palmans, E. W. Meijer   +5 more
openaire   +5 more sources

Nanoscale Metal‐Organic Framework‐Based Self‐Monitoring Oxygen Economizer and ROS Amplifier for Enhanced Radiotherapy‐Radiodynamic Therapy

Advanced Science, EarlyView.
A Fe (III)–Pt (II) porphyrin framework‐based radiosensitizer (FPTM‐LP) is constructed to serve as an oxygen economizer, hypoxia self‐monitoring device, and reactive oxygen species (ROS) amplifier. The glutathione (GSH)/pH‐responsive release of lonidamine achieves oxygen‐economization to combat hypoxia‐induced radioresistance guided by near infrared ...
Shiye Du, Qiang Wen, Ting Han, Jiongyu Ren, Mingyu Wang, Yunpeng Dai, Xiaoguang Ge, Lu Li, Junzhi Liu, Shi Gao   +9 more
wiley   +1 more source

Synthesis of hippuric acid in liver homogenate [PDF]

, 1947
The synthesis of hippuric acid from benaoic acid and glycine resembles in several respects the synthesis of a peptide bond. A CONH group is formed, it is a to a carboxyl group, and the free energy of its formation is of the same order of magnitude.
Borsook, Henry, Dubnoff, Jacob W.
core  

A multinuclear solid state NMR, density functional theory and X-Ray diffraction study of hydrogen bonding in Group I hydrogen dibenzoates [PDF]

, 2013
An NMR crystallographic approach incorporating multinuclear solid state NMR (SSNMR), X-ray structure determinations and density functional theory (DFT) are used to characterise the H bonding arrangements in benzoic acid (BZA) and the corresponding Group ...
Alberth Lari, Andrew P. Howes, Anupold, Arunan, Asakawa, Ashbrook, Barbour, Bastow, Bastow, Cannon, Cheetham, Clark, Cole, Coles, David Quigley, Dinu Iuga, Etter, Farrugia, Fillaux, Fletcher, Gemmecker, Gilli, Glowacki, Gobetto, Gorman, Gowda, Gregory J. Rees, Griffin, Gu, Gu, Gu, Haeberlen, Hagaman, Harris, Harris, Hirsch, Howes, Hung, John D. Wallis, John V. Hanna, Kim, Kuroki, Lee, Macrae, Mark E. Light, Mark E. Smith, Massiot, Mateusz B. Pitak, Milford, Moudrakovski, Oldfield, Panchmatia, Perdew, Perdew, Pickard, Profeta, Samoson, Samoson, Sheldrick, Shimoda, Simon J. Coles, Skinner, Slootmaekers, Sponer, Stephen P. Day, Terry L. Threlfall, Traer, Waugh, Wei, Wilson, Witkowski, Wong, Wong, Wong, Wu, Wu, Wu, Yates   +77 more
core   +2 more sources

Rapid Methylation of Aryl Bromides Using Air‐Stable DABCO‐Bis(Trimethylaluminum) via Nickel Metallaphotoredox Catalysis

Angewandte Chemie, EarlyView.
Herein, we report the use of bis(trimethylaluminum)‐1,4‐diazabicyclo[2.2.2]octane (DABAl‐Me3) as practical source of radicals for the introduction of valuable methyl groups to aryl bromides via a Nickel/metallaphotocatalytic cross coupling strategy.
Jonas Djossou, Andrea Aloia, Luca Capaldo, Demi D. Snabilié, Morgan Regnier, Jasper H.A. Schuurmans, Antonio Monopoli, Bas de Bruin, Timothy Noël   +8 more
wiley   +2 more sources

Organocatalytic C─O Bond Cleavage and Asymmetric Transformations via [1,3]‐Sigmatropic Rearrangement

Advanced Science, EarlyView.
A direct asymmetric strategy for fulfilling the functional group transfer by aryl ether cleavage and migration is developed, representing the first Brønsted base‐catalyzed asymmetric [1,3]‐sigmatropic rearrangement reaction. The resulting chiral benzofuran products generated through this strategy exhibit significant 3D‐dimensionality and demonstrate ...
Lei Peng, Yu Chang, Liangchen Yin, Jinbang Zhang, Xuli Feng, Pengfei Wang, Wenling Qin, Hailong Yan   +7 more
wiley   +1 more source

Isolation and X-ray Structures of Labile Benzoic- and Acetic-Acidium Carbocations [PDF]

, 2005
New carbocationic salts (via O-protonation of substituted benzoic acids) are prepared for the first time by controlled hydration of the corresponding benzoylium salts and isolated in pure crystalline form.
Davlieva, M. G., Kochi, Jay K., Lindeman, Sergey V., Neretin, I. S.   +3 more
core   +1 more source

Direct Activation of Sulfides by C–H Oxidation with Photoexcited Nitroarenes: Formal Manipulations of the C─S Bond

Angewandte Chemie, EarlyView.
Photochemical anaerobic oxidation of sulfides, using nitroarenes as bifunctional reagents, enables the formal manipulation of the C─S bond. The method allows direct and selective access to versatile carbonyl compounds from largely inert sulfides by C–H oxidation, thus avoiding multistep activation by sulfur oxidation.
Valentina D. Cuomo, Ciro Romano, David J. Procter   +2 more
wiley   +2 more sources

Adaptive Antioxidant Nanomedicines Inhibit Ferroptosis in Renal Tubular Epithelial Cells to Alleviate Diabetic Kidney Disease

Advanced Science, EarlyView.
In this study, an adaptive antioxidant nanodrug (AAN) is developed through the self‐polymerization of L‐selenocysteine. The AAN exhibits dual functionalities: antioxidant activity (scavenging reactive oxygen species) and mitochondrial targeting. Moreover, the released selenium (Se) participates in the synthesis of glutathione peroxidase 4 (GPX4), which
Zerun Liu, Ting Huang, Ying Hong, Yuqi Yang, Wensheng Chen, Qingtao Zeng, Qiaohui Chen, Yongqi Yang, Xiaohong Ying, Wan Zeng, Ziyu Wu, Tianjiao Zhao, Xuesi Wan, Jianlin Chen, Kelong Ai, Qiong Huang   +15 more
wiley   +1 more source