Results 251 to 260 of about 16,649 (384)

Advancing obstetrics and gynecology training: The shift toward outcome and based education, a narrative review of literature

open access: yesInternational Journal of Gynecology &Obstetrics, EarlyView.
Abstract Outcome‐based education (OBE) is an educational model that organizes training around the achievement of clearly defined goals rather than time‐based metrics. Its adoption has significantly influenced medical education, particularly in specialties such as obstetrics and gynecology (O&G), where clinical complexity demands adaptability and ...
Orfhlaith E. O'Sullivan   +2 more
wiley   +1 more source

TMB‐High, MSI‐High Castration‐Resistant Prostate Cancer Treated With Pembrolizumab

open access: yesIJU Case Reports, EarlyView.
ABSTRACT Introduction The use of pembrolizumab in patients with microsatellite instability‐high (MSI‐high) and tumor mutation burden‐high (TMB‐high) prostate cancer in Japan is not widely reported. Here, we report the case of a patient with MSI‐high and TMB‐high prostate cancer who responded well to pembrolizumab after multiple systemic treatments ...
Satoshi Muraoka   +8 more
wiley   +1 more source

Diversity of ThDP-Dependent Enzymes Forming Chiral Tertiary Alcohols. [PDF]

open access: yesChembiochem
Bjarnesen D   +4 more
europepmc   +1 more source

RepliChrom: Interpretable machine learning predicts cancer‐associated enhancer‐promoter interactions using DNA replication timing

open access: yesiMeta, EarlyView.
RepliChrom is an interpretable machine learning model that predicts enhancer‐promoter interactions using DNA replication timing across multiple cell types. By integrating replication timing with chromatin interaction data from multiple experimental platforms, it accurately distinguishes true interactions and reveals promoter‐region signals as key ...
Fuying Dao   +7 more
wiley   +1 more source

The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Benedict C. Offor   +3 more
wiley   +1 more source

From PICU to NICU: Extrapolating Meropenem Exposure From Pediatric to Neonatal Intensive Care Patients

open access: yesThe Journal of Clinical Pharmacology, EarlyView.
Abstract We previously developed a population pharmacokinetic (PopPK) model for meropenem in pediatric intensive care unit patients accounting for effect of body size, maturation, and kidney function on clearance. This study aimed to extrapolate meropenem exposure to neonates and young infants using the pediatric PopPK model and to validate the ...
Ronaldo Morales Junior   +4 more
wiley   +1 more source

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