Results 171 to 180 of about 2,756 (214)

Synthesis of benzopyran derivatives as PPARα and/or PPARγ activators

Bioorganic & Medicinal Chemistry, 2019
We describe the synthesis of 26 compounds, small polycerasoidol analogs, that are Lipinski's rule-of-five compliant. In order to confirm key structural features to activate PPARα and/or PPARγ, we have adopted structural modifications in the following parts: (i) the benzopyran core (hydrophobic nucleus) by benzopyran-4-one, dihydrobenzopyran or ...
Bermejo, Almudena, Barrachina, Isabel, El Aouad, Noureddine, Franck, Xavier, Chahboune, Nadia, Andreu, Inmaculada, Figadère, Bruno, Vila, Laura, Hennuyer, Nathalie, Staels, Bart, Dacquet, Catherine, Caignard, Daniel, Sanz, María-Jesús, Cortes, Diego, Cabedo, Nuria   +14 more
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Benzopyrans. Part 23. Nitrogen heterocycles fused with or linked to 1-benzopyran from 3-acyl-2-methyl-1-benzopyran-4-one

Journal of the Chemical Society, Perkin Transactions 1, 1988
The enamine (2), prepared from the title benzopyranone (1; R2= H, Me, and Ph) and dimethylformamide dimethyl acetal, on treatment with ammonia and hydroxylamine gives the fused pyridine (5) and pyridine 2-oxide (10), respectively. Hydrazine, phenylhydrazine, and guanidine undergo initial 1,6-addition to the enamine (2) ultimately giving the pyrazoles ...
Chandra Kanta Ghosh, Chandana Pal, Jharna Maiti, Manjusha Sarkar   +3 more
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2-Benzopyran-3-one

Journal of the Chemical Society, Chemical Communications, 1983
Trapping and low temperature matrix isolation experiments show that 2-benzopyran-3-one (1) is efficiently generated by thermolysis or photolysis of the bis-lactone (2); flash vacuum thermolysis of (2) yields isocoumarin (5) and photolysis of (2) in an argon matrix gives (1) and the ketene (6).
David A. Bleasdale, David W. Jones, G�nther Maier, Hans Peter Reisenauer   +3 more
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Benzopyrans. Part 44. Synthesis of 3‐(4‐Oxo‐4H‐1‐benzopyran‐2‐yl)indolizines.

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Chandra Kanta Ghosh, Sumit Kumar Karak, Amarendra Patra   +2 more
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Convenient Preparation of Pyrano Benzopyranes in Aqueous Media

Synthetic Communications, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
M. Kidwai, S. Saxena
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ChemInform Abstract: Benzopyrans. Part 21. Reaction of 3‐Acyl‐4‐oxo‐4H‐(1)benzopyrans with Diazomethane: Synthesis of Heterocycles Fused with (1)Benzopyran.

ChemInform, 1987
AbstractThe reaction of the benzopyrans (Ia) and (Ib) with excess diazomethane (III) yields the products (II), (IVa), (IVb) and (Va).
C. K. GHOSH, A. BHATTACHARYYA, P. P. GHOSH‐DASTIDAR   +2 more
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Benzopyran sulfonamides as KV1.5 potassium channel blockers

Bioorganic & Medicinal Chemistry Letters, 2007
K(V)1.5 blockers have the potential to be atrium-selective agents for treatment of atrial fibrillation. The benzopyrans provide a template for the synthesis of potent and selective K(V)1.5 blockers.
John, Lloyd, Karnail S, Atwal, Heather J, Finlay, Michael, Nyman, Tram, Huynh, Rao, Bhandaru, Alexander, Kover, Joan, Schmidt, Wayne, Vaccaro, Mary Lee, Conder, Tonya, Jenkins-West, Paul, Levesque   +11 more
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QSAR studies on benzopyran potassium channel activators

European Journal of Medicinal Chemistry, 2006
QSAR studies on a series of benzopyrans as potassium channel activators have been carried out using a large set of distance-based topological indices. In addition, the molecular descriptors namely: negentropy and molecular redundancy indices have also been used.
V. K. Agrawal, J. Singh, M. Gupta, Y. A. Jaliwala, P. V. Khadikar, SUPURAN, CLAUDIU TRANDAFIR   +5 more
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Novel photochromism of differently-linked bis-benzopyrans

Organic & Biomolecular Chemistry, 2007
The unique photochromic bis-chromene 5 incorporates the structural attributes of both 3 and 4 . UV-vis irradiation of 5 leads to a dark brown colour, which is formed by mixing the purple and red colours observed for the photolysates of 3 and 4 , respectively.
Jarugu Narasimha, Moorthy, Parthasarathy, Venkatakrishnan, Subhas, Samanta   +2 more
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Multidimensional Photochemistry Model: Application to Aminobenzonitrile and Benzopyran

19th International Conference on Ultrafast Phenomena, 2014
To understand the photoreactivity of aminobenzonitrile and benzopyran, their electronic structures and the potential energy landscapes were analyzed at the CASSCF level and models were developed to perform quantum dynamics ...
Perveaux, Aurélie, Gatti, Fabien, Meyer, Hans-Dieter, Lasorne, Benjamin, Lauvergnat, David, Castro, Pedro J., Reguero, M.   +6 more
openaire   +1 more source