Results 31 to 40 of about 10,665 (213)

Benzothiophene carboxamide derivatives as novel antimalarials [PDF]

IUBMB Life, 2011
AbstractBromo‐benzothiophene carboxamide derivatives have been shown in the preceding article to inhibit Plasmodium falciparum Enoyl‐ACP reductase. Here, we report bromo‐benzothiophene carboxamide derivatives as potent inhibitors of Plasmodium asexual blood‐stages in vitro as well as in vivo in the mouse model.
Banerjee, Tanushree, Kapoor, Neha, Surolia, Namita, Surolia, Avadhesha   +3 more
openaire   +2 more sources

Deprotonative C(sp3)/C(sp2)–H (Multi)Silylation of (Hetero)Arenes Mediated by NaTMP

Angewandte Chemie, EarlyView.
An operationally simple protocol using a strongly basic sodium amide in combination with sterically emcumbered silicon electrophiles enables the deprotonative C–H (multi)silylation of a myriad of (hetero)arenes. Mechanistic investigations highlight the pivotal role of steric and coordination effects in controlling the regioselectivity and efficiency of
David Sánchez‐Roa, Sophia Belrhomari, Ana McGinley, Clevin Anto Liju, Manting Mu, Max García‐Melchor, Eva Hevia   +6 more
wiley   +2 more sources

Synthesis of 3-chloro-N′-(2-hydroxy-6-pentadecylbenzylidene)benzothiophene-2-carbohydrazide

Journal of Saudi Chemical Society, 2014
3-Chloro-N′-(2-hydroxy-6-pentadecylbenzylidene)benzothiophene-2-carbohydrazide has been synthesized by the reaction of 2-hydroxy-6-pentadecylbenzaldehyde with 3-chloro-1-benzothiophene-2-carboxylicacidhydrazide in the presence of glacial acetic acid in ...
Gadada Naganagowda, Patchanita Thamyongkit, Runchana Klai-U-dom, Orathip Pengsakut, Amorn Petsom   +4 more
doaj   +1 more source

Conversion of sulphur compounds into light gas oil: I. Kinetics of the conversion of model compounds [PDF]

Hemijska Industrija, 2002
The problem of sulfur compounds conversion, particularly heterocyclic compounds, from the middle fraction of crude oil (light gas oil) was analyzed and will be published in several articles in the Chemical Industry Journal.
Janković Jasna, Skala Dejan U.
doaj   +1 more source

The Influence of Various Factors on Nanocatalyst Activity during Benzothiophene Hydrogenation

Applied Sciences, 2022
Herein, we disclosed a method of preparing a nanocatalyst containing nickel-cobalt by impregnation in a hydrochloric acid medium. Optimal conditions were established for all stages of nanocatalyst preparation using the method of probabilistic ...
Aigerim Barshabayeva, Nazerke Balpanova, Darzhan Aitbekova, Murzabek Baikenov, Yermek Aubakirov, Z. S. Khalikova, Almas Tusipkhan, Balzhan Tulebaeva, Taurbaeva Gulzhan   +8 more
doaj   +1 more source

Microwave-assisted synthesis of 3-aminobenzo[b]thiophene scaffolds for the preparation of kinase inhibitors [PDF]

, 2015
Microwave irradiation of 2-halobenzonitriles and methyl thioglycolate in the presence of triethylamine in DMSO at 130 °C provides rapid access to 3-aminobenzo[b]thiophenes in 58–96% yield.
Bagley, Mark C, Beltran Molina, Maria D, Dwyer, Jessica E, Rand, Alexander W, Rand, Hayley L, Tomkinson, Nicholas C O   +5 more
core   +1 more source

Intermolecular Electrophilic Germylation Using GeCl4 and Al2Cl6

Angewandte Chemie, EarlyView.
While electrophilic aromatic substitution is well‐established for carbon and silicon‐based electrophiles, it is extremely underdeveloped for germanium. Herein we report the first effective intermolecular Germa–Friedel–Crafts reaction. The process can be modified to enable selective synthesis of the mono‐ or the di‐aryl germane derivatives, ArGeCl3 and ...
Justyna Łosiewicz, Milan Kumar Bisai, Zachary A. Bub, Stuart A. Macgregor, Michael J. Ingleson   +4 more
wiley   +2 more sources

3-Methyl-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxylic Acid

Molbank, 2010
3-Methyl-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxylic acid was synthesized chemoselectively from 3-formyl-4,5,6,7-tetrahydro-1-benzothiophene-2-carboxylic acid, using Et3SiH/I2 as a reducing agent.
Rajendiran Nagappan, Madhavan Sridharan, Sembian Ruso Jayaraman   +2 more
doaj   +1 more source

Crystal structure of 2-amino-N-(2-fluorophenyl)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C15H15FN2OS, the dihedral angle between the planes of the benzothiophene ring system and the fluorobenzene ring is 3.74 (14)°. The six-membered ring of the benzothiophene moiety adopts a half-chair conformation.
K. Chandra Kumar, V. Umesh, T. K. Madhura, B. M. Rajesh, Chandra   +4 more
doaj   +1 more source

Targeted Synthesis and Analysis of Biologically Active Azomethine Derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide

Разработка и регистрация лекарственных средств, 2021
Introduction. Azomethine derivatives of 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide are acyclic precursors of biologically active compounds derived from 5,6,7,8-tetrahydro-3H-benzoteopheno[2,3-d]pyrimidine-4-one. Examples of these groups of
A. S. Chiriapkin, I. P. Kodonidi, M. V. Larsky   +2 more
doaj   +1 more source