Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction [PDF]
Beilstein Journal of Organic Chemistry, 2023 A convenient synthetic procedure for the construction of novel dispirooxindole motifs was successfully developed by base-promoted three-component reaction of ammonium acetate, isatins and in situ-generated 3-isatyl-1,4-dicarbonyl compounds.
Ziying Xiao +3 more
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Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity [PDF]
Molecules, 2023 Novel variously substituted thiohydantoin-based dispiro-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, and sarcosine.
Yan A. Ivanenkov +10 more
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[3+2]-Cycloaddition of azomethine ylides to 5-methylidene-3-aryl-2-сhalcogen-imidazolones: access to dispiro indolinone-pyrrolidine-imidazolones [PDF]
Royal Society Open Science, 2022 A synthesis of dispiro derivatives from 5-methylidene-2-chalcogenimidazolones and azomethine ylides generated from isatins and N-substituted α-amino acids has been developed.
Maxim E. Kukushkin +9 more
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Organocatalyzed Enantioselective [3+2] Cycloaddition Reactions for Synthesis of Dispiro[benzothiophenone-indandione-pyrrolidine] Derivatives [PDF]
MoleculesAn organocatalytic enantioselective [3+2] cycloaddition reaction involving 2-arylidene-1,3-indandiones and N-2,2-difluoroethylbenzothiophenone imines was developed.
Hong-Yan Liu, Da-Ming Du
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Design, synthesis, and biological evaluation of multifunctional dispiro chromeno-indenoquinoxaline hybrids as dual anticancer and antibacterial agents with metal-ion sensing ability [PDF]
RSC AdvancesWe have developed for the first time an aqueous-mediated 1,3-dipolar cycloaddition between indenoquinoxaline-derived nitrones and structurally diverse 2H-chromenes for the efficient construction of dispiro-chromeno-indenoquinoxaline frameworks.
Kamalika Prusty +11 more
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Pyrrolidine-Based Antifungal Agents Against Candida Species: A Systematic Review of Structure–Activity Relationships and Mechanistic Insights from Experimental Studies [PDF]
PharmaceuticalsBackground: Invasive and mucosal infections caused by Candida species continue to pose a significant global health burden, particularly due to the species’ increasing resistance to conventional antifungal agents.
Harinahalli Ganesh Sinchan +2 more
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Isolation of kinetically-stabilised diarylchalcogenide radical cations [PDF]
Communications ChemistryChalcogenide radical cations [R2E]•+ (E = S, Se, Te) are commonly short-lived intermediates of fundamental interest. Sulfide radical cations in particular are associated in vivo with oxidative stress and neuropathological processes.
Pascal Komorr +7 more
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Synthesis and structure of 1′,4′-diphenyl-1a,1′,4′,4′′,5′′,9b-hexahydro-2′′H-dispiro[cyclopropa[l]phenanthrene-1,2′-[1,4]epoxynaphthalene-3′,3′′-thiophene] [PDF]
Acta Crystallographica Section E: Crystallographic CommunicationsThe title compound, C39H30OS, was inadvertently prepared as a Diels–Alder adduct between 1,3-diphenylisobenzofuran and 3-(1a,9b-dihydro-1H-cyclopropa[l]phenanthren-1-ylidene)tetrahydrothiophene.
Yuewei Wen, Dasan M. Thamattoor
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Semisynthesis of Novel Dispiro-pyrrolizidino/thiopyrrolizidino-oxindolo/indanedione Natural Product Hybrids of Parthenin Followed by Their Cytotoxicity Evaluation [PDF]
ACS Omega, 2023 Chetan Paul Singh +9 more
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7,8,15,16-tetraoxa-dispiro[5.2.5.2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity [PDF]
Journal of the Serbian Chemical Society, 2004 Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains,
BOGDAN SOLAJA +4 more
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