Results 1 to 10 of about 1,332 (148)

[3+2]-Cycloaddition of azomethine ylides to 5-methylidene-3-aryl-2-сhalcogen-imidazolones: access to dispiro indolinone-pyrrolidine-imidazolones [PDF]

Royal Society Open Science, 2022
A synthesis of dispiro derivatives from 5-methylidene-2-chalcogenimidazolones and azomethine ylides generated from isatins and N-substituted α-amino acids has been developed.
Maxim E Kukushkin, Dmitry E Shybanov, V A Tafeenko   +2 more
exaly   +5 more sources

Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction [PDF]

Beilstein Journal of Organic Chemistry, 2023
A convenient synthetic procedure for the construction of novel dispirooxindole motifs was successfully developed by base-promoted three-component reaction of ammonium acetate, isatins and in situ-generated 3-isatyl-1,4-dicarbonyl compounds.
Ziying Xiao, Fengshun Xu, Jing Sun, Chao-Guo Yan   +3 more
doaj   +3 more sources

Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity [PDF]

Molecules, 2023
Novel variously substituted thiohydantoin-based dispiro-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, and sarcosine.
Yan A. Ivanenkov, Maxim E. Kukushkin, Anastasia A. Beloglazkina, Radik R. Shafikov, Alexander A. Barashkin, Andrey A. Ayginin, Marina S. Serebryakova, Alexander G. Majouga, Dmitry A. Skvortsov, Viktor A. Tafeenko, Elena K. Beloglazkina   +10 more
doaj   +3 more sources

Organocatalyzed Enantioselective [3+2] Cycloaddition Reactions for Synthesis of Dispiro[benzothiophenone-indandione-pyrrolidine] Derivatives [PDF]

Molecules
An organocatalytic enantioselective [3+2] cycloaddition reaction involving 2-arylidene-1,3-indandiones and N-2,2-difluoroethylbenzothiophenone imines was developed.
Hong-Yan Liu, Da-Ming Du
doaj   +3 more sources

Semisynthesis of Novel Dispiro-pyrrolizidino/thiopyrrolizidino-oxindolo/indanedione Natural Product Hybrids of Parthenin Followed by Their Cytotoxicity Evaluation [PDF]

ACS Omega, 2023
Natural products possess unique and broader intricacies in the chemical space and have been essential for drug discovery. The crucial factor for drug discovery success is not the size of the library but rather its structural diversity.
Chetan Paul Singh, Priyanka Sharma, Manzoor Ahmed, Diljeet Kumar, Yogesh Brijwashi Sharma, Jayanta Samanta, Zabeer Ahmed, Sanket Kumar Shukla, Abhijit Hazra, Yogesh P. Bharitkar   +9 more
doaj   +3 more sources

Synthesis and structure of 1′,4′-diphenyl-1a,1′,4′,4′′,5′′,9b-hexahydro-2′′H-dispiro[cyclopropa[l]phenanthrene-1,2′-[1,4]epoxynaphthalene-3′,3′′-thiophene] [PDF]

Acta Crystallographica Section E: Crystallographic Communications
The title compound, C39H30OS, was inadvertently prepared as a Diels–Alder adduct between 1,3-diphenylisobenzofuran and 3-(1a,9b-dihydro-1H-cyclopropa[l]phenanthren-1-ylidene)tetrahydrothiophene.
Yuewei Wen, Dasan M. Thamattoor
doaj   +3 more sources

Stereoselective Synthesis of a Novel Series of Dispiro-oxindolopyrrolizidines Embodying Thiazolo[3,2-a]benzimidazole Motif: A Molecular Electron Density Theory Study of the Mechanism of the [3 + 2] Cycloaddition Reaction

Chemistry, 2023
A one-pot multi-component reaction was employed for the stereoselective synthesis of a novel set of dispiro-oxindolopyrrolizidines analogs incorporating a thiazolo[3,2-a]benzimidazole scaffold based on the [3 + 2] cycloaddition (32CA) reaction approach ...
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, M. Ali, Mar Ríos-Gutiérrez   +5 more
doaj   +2 more sources

Diastereoselective Synthesis of Dispiro[Imidazothiazolotriazine-Pyrrolidin-Oxindoles] and Their Isomerization Pathways in Basic Medium [PDF]

Int J Mol Sci, 2023
Highly diastereoselective methods for the synthesis of two series of regioisomeric polynuclear dispyroheterocyclic compounds with five or six chiral centers, comprising moieties of pyrrolidinyloxindole and imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine of ...
Izmest′ev A, Vinogradov D, Kravchenko A, Kolotyrkina N, Gazieva G.   +4 more
europepmc   +2 more sources

Innovative regioselective synthesis of dispiro[fluorene-9,3'-pyrazole-5',4″-pyrazolidines]: experimental and computational study. [PDF]

RSC Adv
A simple one-pot protocol is described for the synthesis of dispiro[fluorene-9,3′-pyrazole-5′,4″-pyrazolidines] via a [3 + 2] cycloaddition reaction between 9-diazo-9H-fluorene (DF) and a series of (E/Z)-4-arylidene-1-phenylpyrazolidine-3,5-diones (APPs).
Hussein EM, Moussa Z, Al-Rooqi MM, Samman SS, Alsimaree AA, Jassas RS, Ahmed SA.   +6 more
europepmc   +2 more sources

Chlorfortunones A and B, Two Sesquiterpenoid Dimers, Possessing Dispiro[4,2,5,2]pentadecane-6,10,14-tren Moiety from Chloranthus fortunei. [PDF]

ACS Omega, 2022
Chlorfortunones A (1) and B (2), two novel sesquiterpenoid dimers, were isolated from the roots of Chloranthus fortunei. Their structures were elucidated by spectroscopic analysis and X-ray diffraction analysis.
Wu XJ, Cao D, Chen FL, Shen RS, Gao J, Bai LP, Zhang W, Zhang W, Jiang ZH, Zhu GY.   +9 more
europepmc   +2 more sources