Results 1 to 10 of about 111 (85)

7,8,15,16-tetraoxa-dispiro[5.2.5.2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity [PDF]

Journal of the Serbian Chemical Society, 2004
Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains,
BOGDAN SOLAJA, WILBUR K. MILHOUS, DEJAN OPSENICA, NATASA TERZIC, IGOR OPSENICA   +4 more
doaj   +3 more sources

[3+2]-Cycloaddition of azomethine ylides to 5-methylidene-3-aryl-2-сhalcogen-imidazolones: access to dispiro indolinone-pyrrolidine-imidazolones

Royal Society Open Science, 2022
A synthesis of dispiro derivatives from 5-methylidene-2-chalcogenimidazolones and azomethine ylides generated from isatins and N-substituted α-amino acids has been developed.
Maxim E. Kukushkin, Alexandra A. Kondratieva, Nikita A. Karpov, Dmitry E. Shybanov, Viktor A. Tafeenko, Vitaly A. Roznyatovsky, Yuri K. Grishin, Anna A. Moiseeva, Nikolai V. Zyk, Elena K. Beloglazkina   +9 more
doaj   +1 more source

Stereoselective Synthesis of a Novel Series of Dispiro-oxindolopyrrolizidines Embodying Thiazolo[3,2-a]benzimidazole Motif: A Molecular Electron Density Theory Study of the Mechanism of the [3 + 2] Cycloaddition Reaction

Chemistry, 2023
A one-pot multi-component reaction was employed for the stereoselective synthesis of a novel set of dispiro-oxindolopyrrolizidines analogs incorporating a thiazolo[3,2-a]benzimidazole scaffold based on the [3 + 2] cycloaddition (32CA) reaction approach ...
Assem Barakat, Saeed Alshahrani, Abdullah Mohammed Al-Majid, Abdullah Saleh Alamary, M. Ali, Mar Ríos-Gutiérrez   +5 more
doaj   +1 more source

Tautomerism troubles: proton transfer modifies the stereochemical assignments in diastereoisomeric structures of spirocyclic 5-methyl-2H-imidazol-4-amine dimers

Acta Crystallographica Section E: Crystallographic Communications, 2021
During the racemization of a novel pharmaceutical spirocyclic imidazole–amine compound, namely, 6′-bromo-N-(6′-bromo-4-methoxy-4′′-methyl-3′H-dispiro[cyclohexane-1,2′-indene-1′,2′′-imidazol]-5′′-yl)-4-methoxy-4′′-methyl-3′H-dispiro[cyclohexane-1,2 ...
Helen Blade, Peter N. Horton, James A. Morrison, James B. Orton, Rachel A. Sullivan, Simon J. Coles   +5 more
doaj   +1 more source

Strain‐Release Driven Epoxidation and Aziridination of Bicyclo[1.1.0]butanes via Palladium Catalyzed σ‐Bond Nucleopalladation

Angewandte Chemie, Volume 135, Issue 7, February 6, 2023., 2023
Strained spirocyclic epoxides and aziridines were synthesized via three‐component coupling between in situ generated 1‐lithio bicyclo [1.1.0]butane, a broad variety of ketones, aldehydes and N‐tosyl imines, and aryl triflates. The key step involves a highly diastereoselective palladium‐catalyzed C−C σ‐bond alkoxyarylation (or aminoarylation) of bicyclo
Bernhard Wölfl, Nils Winter, Jiajing Li, Adam Noble, Varinder K. Aggarwal   +4 more
wiley   +2 more sources

Selective construction of dispiro[indoline-3,2'-quinoline-3',3''-indoline] and dispiro[indoline-3,2'-pyrrole-3',3''-indoline] via three-component reaction

Beilstein Journal of Organic Chemistry, 2023
A convenient synthetic procedure for the construction of novel dispirooxindole motifs was successfully developed by base-promoted three-component reaction of ammonium acetate, isatins and in situ-generated 3-isatyl-1,4-dicarbonyl compounds.
Ziying Xiao, Fengshun Xu, Jing Sun, Chao-Guo Yan   +3 more
doaj   +1 more source

Bifunctional thiourea-catalyzed asymmetric [3 + 2] annulation reactions of 2-isothiocyanato-1-indanones with barbiturate-based olefins

Beilstein Journal of Organic Chemistry, 2022
Bifunctional thiourea-catalyzed asymmetric [3 + 2] annulation reactions of 2-isothiocyanato-1-indanones with barbiturate-based olefins have been developed to afford chiral dispiro[indene-pyrrolidine-pyrimidine]s.
Jiang-Song Zhai, Da-Ming Du
doaj   +1 more source

Synthesis and Biological Evaluation of Novel Dispiro-Indolinones with Anticancer Activity

Molecules, 2023
Novel variously substituted thiohydantoin-based dispiro-indolinones were prepared using a regio- and diastereoselective synthetic route from 5-arylidene-2-thiohydantoins, isatines, and sarcosine.
Yan A. Ivanenkov, Maxim E. Kukushkin, Anastasia A. Beloglazkina, Radik R. Shafikov, Alexander A. Barashkin, Andrey A. Ayginin, Marina S. Serebryakova, Alexander G. Majouga, Dmitry A. Skvortsov, Viktor A. Tafeenko, Elena K. Beloglazkina   +10 more
doaj   +1 more source

Cyclotrimerization Approach to Symmetric [9]Helical Indenofluorenes: Diverting Cyclization Pathways

Chemistry – A European Journal, Volume 29, Issue 58, October 18, 2023., 2023
Catalytic cyclotrimerization (Rh, Co, and Ni catalysts) of triyne 1 gives rise preferentially to [9]helical indenofluorene, whereas it thermal cyclization gives rise to polyaromatic hydrocarbon 3. The former reaction proceeds via classical alkyne cyclotrimerization, the latter via dehydro‐Diels–Alder reaction accompanied by unusual C−C cleavage.
Timothée Cadart, Tim Gläsel, Ivana Císařová, Róbert Gyepes, David Nečas, Marko Hapke, Martin Kotora   +6 more
wiley   +1 more source

Phytochemicals from Leucas zeylanica Targeting Main Protease of SARS-CoV-2: Chemical Profiles, Molecular Docking, and Molecular Dynamics Simulations

Biology, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a contemporary coronavirus, has impacted global economic activity and has a high transmission rate.
Mycal Dutta, Abu Montakim Tareq, Ahmed Rakib, Shafi Mahmud, Saad Ahmed Sami, Jewel Mallick, Mohammad Nazmul Islam, Mohuya Majumder, Md. Zia Uddin, Abdullah Alsubaie, Abdulraheem S. A. Almalki, Mayeen Uddin Khandaker, D.A. Bradley, Md. Sohel Rana, Talha Bin Emran   +14 more
doaj   +1 more source