Results 11 to 20 of about 1,879 (233)

Synthesis, antimalarial activity evaluation and molecular docking studies of some novel dispiro-1,2,4,5-tetraoxanes

Bangladesh Journal of Pharmacology, 2015
Seven novel dispiro-1,2,4,5-tetraoxane derivatives were synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were subsequently screened for in vitro antimalarial activity against chloroquine resistant strain
Mukesh Kumar Kumawat, Dipak Chetia
doaj   +9 more sources

7,8,15,16-tetraoxa-dispiro[5.2.5.2]hexadecane-3-carboxylic acid derivatives and their antimalarial activity [PDF]

Journal of the Serbian Chemical Society, 2004
Several C2 symmetrical mixed tetraoxanes were prepared starting from a gemdihydroperoxide and a ketone. The obtained tetraoxanes showed pronounced antimalarial activity against P. falciparum chloroquine resistant W2 and chloroquine susceptible D6 strains,
BOGDAN SOLAJA, WILBUR K. MILHOUS, DEJAN OPSENICA, NATASA TERZIC, IGOR OPSENICA   +4 more
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New Dispiro Compounds:  Synthesis and Properties

Organic Letters, 2008
We report the synthesis and structural characterization of two dispiro compounds. These two positional isomers have been designed and synthesized through an efficient method. Because of the rigidity and orthogonality of the spiro bridge, both molecules exhibit a well-defined architecture which consists of two fluorene rings connecting to an ...
Poriel, Cyril, Rault-Berthelot, Joëlle, Barrière, Frédéric, M. Z. Slawin, Alexandra   +3 more
openaire   +3 more sources

Piperidine dispiro-1,2,4-trioxane analogues

Bioorganic & Medicinal Chemistry Letters, 2008
Dispiro N-Boc-protected 1,2,4-trioxane 2 was synthesised via Mo(acac)(2) catalysed perhydrolysis of N-Boc spirooxirane followed by condensation of the resulting beta-hydroperoxy alcohol 10 with 2-adamantanone. N-Boc 1,2,4-trioxane 2 was converted to the amine 1,2,4-trioxane hydrochloride salt 3 which was subsequently used to prepare derivatives (4-7 ...
Sunil, Sabbani, Paul A, Stocks, Gemma L, Ellis, Jill, Davies, Erik, Hedenstrom, Stephen A, Ward, Paul M, O'Neill   +6 more
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The activity of dispiro peroxides against Fasciola hepatica [PDF]

Bioorganic & Medicinal Chemistry Letters, 2011
Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F.
Wang, Xiaofang, Zhao, Qingjie, Vargas, Mireille, Dong, Yuxiang, Sriraghavan, Kamaraj, Keiser, Jennifer, Vennerstrom, Jonathan L.   +6 more
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Highly Efficient and Stereoselective Construction of Dispiro-[oxazolidine-2-thione]bisoxindoles and Dispiro[imidazolidine-2-thione]bisoxindoles

Organic Letters, 2012
An efficient and stereoselective reaction between 3-isothiocyanato oxindoles and isatins/isatinimines has been developed to afford structurally diverse dispiro[oxazolidine-2-thione]bisoxindoles and dispiro[imidazolidine-2-thione]bisoxindoles in excellent results under mild conditions. The potential of asymmetric induction by means of a chiral auxiliary
Yan-Yan, Han, Wen-Bing, Chen, Wen-Yong, Han, Zhi-Jun, Wu, Xiao-Mei, Zhang, Wei-Cheng, Yuan   +5 more
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Isolation of kinetically-stabilised diarylchalcogenide radical cations [PDF]

Communications Chemistry
Chalcogenide radical cations [R2E]•+ (E = S, Se, Te) are commonly short-lived intermediates of fundamental interest. Sulfide radical cations in particular are associated in vivo with oxidative stress and neuropathological processes.
Pascal Komorr, Corina Stoian, Aleksa Radović, Björn A. Meyer, Pim Puylaert, George E. Cutsail III, Emanuel Hupf, Jens Beckmann   +7 more
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Stereoselective Synthesis of Novel Dispiro Oxindole-pyrrolothiazole-androsterone Hybrids [PDF]

Synthetic Communications, 2014
A facile synthesis of novel dispiro oxindole-pyrrolothiazole-androsterone hybrid heterocycles has been achieved through 1,3-dipolar cycloaddition. The reaction proceeds stereo- and regioselectively, affording a single isomer of the product in excellent yields with the formation of two C–C and one C–N bonds and creation of four new contiguous ...
Kanchithalaivan, Selvaraj, Anusha Rani, Mani, Kumar, Raju Ranjith   +2 more
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Synthesis and crystal structure (3R,4′S)-4′-(3,5-dibromophenyl)-1′-methyl-2H-dispiro [benzofuran-3,3′-pyrrolidine-2′,2″-indene]-1″,2,3″-trione, C26H17Br2NO4

Zeitschrift für Kristallographie - New Crystal Structures
C26H17Br2NO4, triclinic, P1¯ (no. 2), a = 8.3900(2) Å, b = 11.9445(2) Å, c = 12.4155(2) Å, α = 74.4620(10)°, β = 81.802(2)°, γ = 70.601(2)°, V = 1128.72(4) Å3, Z = 2, Rgt(F) = 0.0449, wRref(F2) = 0.1228, T = 249(1) K.
Chai Yi-Hui, Fan Zhi-Ling, Dong Zhang-Chao, Shi Yang, Liu Li-Juan, Pan Bo-Wen, Yang Fang-Fang   +6 more
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Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

Bioorganic & Medicinal Chemistry Letters, 2007
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
Tang, Yuanqing, Dong, Yuxiang, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C. K., Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Bajpai, Saroj, Wang, Xiaofang, Padmanilayam, Maniyan, Karle, Jean M., Brun, Reto, Vennerstrom, Jonathan L.   +15 more
openaire   +5 more sources