Results 11 to 20 of about 161 (128)

Synthesis, antimalarial activity evaluation and molecular docking studies of some novel dispiro-1,2,4,5-tetraoxanes

Bangladesh Journal of Pharmacology, 2015
Seven novel dispiro-1,2,4,5-tetraoxane derivatives were synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were subsequently screened for in vitro antimalarial activity against chloroquine resistant strain
Mukesh Kumar Kumawat, Dipak Chetia
doaj   +8 more sources

Recent Advances in Multicomponent Electro‐Organic (Electrochemical) Synthesis of Heterocycles

Asian Journal of Organic Chemistry, Volume 12, Issue 8, August 2023., 2023
This review provides a summary of electrosynthesis methods that can be used as an alternative method for synthesis of complex organic molecules in pharmaceutical and biological applications. This method involves electro‐organic reactions occurring at room temperature and normal pressure through transferring electrons.
Sahar Imeni, Ata Makarem, Ramin Javahershenas   +2 more
wiley   +1 more source

Crystal structure of ethyl 2′′,3-dioxo-7′,7a'-dihydro-1′H,3H,3′H-dispiro[benzo[b]thiophene-2,6′-pyrrolo[1,2-c]thiazole-5′,3′′-indoline]-7′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C23H20N2O4S2, the central pyrrolidine ring adopts an envelope conformation with the spiro C atom, shared with the benzothiophene ring system, as the flap.
M. P. Savithri, M. Suresh, R. Raghunathan, R. Raja, A. SubbiahPandi   +4 more
doaj   +1 more source

Kinetically Stabilized Diarylpnictogenium Ions

ChemPlusChem, Volume 88, Issue 3, March 2023., 2023
The preparation and full characterization of the stibenium and bismuthenium ions completes the series of kinetically stabilized heavier pnictogenium ions [RindMesE]+ (E=P, As Sb, Bi). The different colours of the species within this series were attributed to energy differences of the LUMOs. Comparison with the bis(m‐terphenyl)‐substituted stibenium and
Marvin Janssen, Stefan Mebs, Jens Beckmann   +2 more
wiley   +1 more source

Syntheses of dispiro[2.1.4.1]decane and dispiro[2.0.3.3]decane

Tetrahedron Letters, 2000
Abstract Efficient syntheses of the hitherto unknown hydrocarbons dispiro[2.1.4.1]decane and dispiro[2.0.3.3]decane have been realized through reaction sequences involving spiro[3.4]octan-2-one and spiro[3.4]octan-5-one as key intermediates.
John E Baldwin, Maryann E Keene, Rajesh Shukla   +2 more
openaire   +1 more source

The activity of dispiro peroxides against Fasciola hepatica [PDF]

Bioorganic & Medicinal Chemistry Letters, 2011
Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F.
Wang, Xiaofang, Zhao, Qingjie, Vargas, Mireille, Dong, Yuxiang, Sriraghavan, Kamaraj, Keiser, Jennifer, Vennerstrom, Jonathan L.   +6 more
openaire   +4 more sources

Crystal structure of ethyl 5′′-fluoro-2′′,3-dioxo-6′,7′,8′,8a'-tetrahydro-2′H,3H,5′H-dispiro[benzo[b]thiophene-2,1′-indolizine-3′,3′′-indoline]-2′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C25H23FN2O4S, the fused piperidine ring of the octahydroindolizine ring system adopts a chair conformation and the five-membered ring has a twisted conformation on the N—C(spiro) bond.
R. Raja, J. Govindaraj, M. Suresh, R. Raghunathan, A. SubbiahPandi   +4 more
doaj   +1 more source

The Effect of Benzannulation on the Structures, Reactivity and Molecular Dynamics of Indenes, Pentalenes, Azulenes and Related Molecules

Molecules, 2022
The stabilising effect of benzannulation on isoindenes formed in the course of sigmatropic shifts of (C5H5)Fe(CO)2 or of organo-silyl groups, and on exocyclic allyl intermediates in the course of haptotropic shifts of organometallic fragments over ...
Michael J. McGlinchey
doaj   +1 more source

Crystal structures of ethyl (2S*,2′R*)-1′-methyl-2′′,3-dioxo-2,3-dihydrodispiro[1-benzothiophene-2,3′-pyrrolidine-2′,3′′-indoline]-4′-carboxylate and ethyl (2S*,2′R*)-5′′-chloro-1′-methyl-2′′,3-dioxo-2,3-dihydrodispiro[1-benzothiophene-2,3′-pyrrolidine-2′,3′′-indoline]-4′-carboxylate

Acta Crystallographica Section E, 2014
In the title compounds, C22H20N2O4S, (I), and C22H19ClN2O4S, (II), the pyrrolidine rings have twist conformations on the spiro–spiro C—C bonds. In (I), the five-membered ring of the oxindole moiety has an envelope conformation with the spiro C atom as ...
M. P. Savithri, M. Suresh, R. Raghunathan, G. Vimala, R. Raja, A. SubbiahPandi   +5 more
doaj   +1 more source

Crystal structure of ethyl 1′,5-dimethyl-2′′,3-dioxo-3H-dispiro[benzo[b]thiophene-2,3′-pyrrolidine-2′,3′′-indoline]-4′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
The title compound, C23H22N2O4S, crystallized with two independent molecules (A and B) in the asymmetric unit. They have very similar conformations with the pyrrolidine ring having a twisted conformation, on the Cspiro—Cspiro bond, in both molecules.
R. Raja, J. Govindaraj, M. Suresh, R. Raghunathan, A. SubbiahPandi   +4 more
doaj   +1 more source