Results 1 to 10 of about 10,665 (213)

Crystal structure of ethyl (2S,2′R)-1′-benzyl-3-oxo-3H-dispiro[1-benzothiophene-2,3′-pyrrolidine-2′,11′′-indeno[1,2-b]quinoxaline]-4′-carboxylate [PDF]

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C35H27N3O3S, the spiro-linked five-membered rings both adopt twisted conformations. The pyrrolidine ring makes dihedral angles of 80.5 (1) and 77.4 (9)° with the benzothiophene ring system and the quinoxaline ring system ...
J. Govindaraj, R. Raja, M. Suresh, R. Raghunathan, A. SubbiahPandi   +4 more
doaj   +7 more sources

Benzo[b]tiophen-3-ol derivatives as effective inhibitors of human monoamine oxidase: design, synthesis, and biological activity [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
A series of benzo[b]thiophen-3-ols were synthesised and investigated as potential human monoamine oxidase (hMAO) inhibitors in vitro as well as ex vivo in rat cortex synaptosomes by means of evaluation of 3,4-dihydroxyphenylacetic acid/dopamine (DOPAC/DA)
Paolo Guglielmi, Daniela Secci, Anél Petzer, Donatella Bagetta, Paola Chimenti, Giulia Rotondi, Claudio Ferrante, Lucia Recinella, Sheila Leone, Stefano Alcaro, Gokhan Zengin, Jacobus P. Petzer, Francesco Ortuso, Simone Carradori   +13 more
doaj   +2 more sources

Structural elucidation and Hirshfeld surface analysis of a fused thiophene ester: methyl 3-[(naphtho[2,1-b]thiophen-5-yl)methyl]-1-benzothiophene-2-carboxylate [PDF]

Acta Crystallographica Section E: Crystallographic Communications
The title compound, C23H16O2S2, is a benzo[b]thiophene-2-carboxylate derivative and consists of naphthothiophene and benzothiophene moieties bridged by a methylene group.
Sekaran Ranjith, Ayyamperumal Nataraj, Kabali Divya Bharathi, Arasambattu K. Mohanakrishnan   +3 more
doaj   +2 more sources

Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners [PDF]

Molecules, 2017
Malaria is a severe and life-threatening disease caused by Plasmodium parasites that are spread to humans through bites of infected Anopheles mosquitoes.
Jelena Konstantinović, Milica Videnović, Jelena Srbljanović, Olgica Djurković-Djaković, Katarina Bogojević, Richard Sciotti, Bogdan Šolaja   +6 more
doaj   +5 more sources

Novel Insights on Benzo[b]thiophene Analogues for MAO-B Inhibition and Neuroprotection: Design, Synthesis, Molecular Modelling Studies and Biological Activity [PDF]

Antioxidants
Neurodegenerative disorders (NDs), such as Alzheimer’s disease and Parkinson’s disease (PD), represent a significant challenge for ageing populations, with their prevalence increasing worldwide.
Francesca Arrighi, Emanuela Berrino, Paolo Guglielmi, Simone Carradori, Guya Diletta Marconi, Jacopo Pizzicannella, Simone Guarnieri, Tiziano Tuccinardi, Giulio Poli, Federico Pepi, Anna Troiani, Chiara Salvitti, Alessia Di Noi, Michele Coluccia, Giorgio Buttitta, Virginia Pontecorvi, Arianna Granese, Paola Chimenti, Daniela Secci, Anel Petzer, Jacobus Petrus Petzer, Francesca Diomede   +21 more
doaj   +2 more sources

Structure-Guided Discovery of Benzoic-Acid-Based TRPC6 Ligands: An Integrated Docking, MD, and MM-GBSA SAR Study: Potential Therapeutic Molecules for Autism Spectrum Disorder [PDF]

Pharmaceuticals
Background: TRPC6 is recognized as a therapeutically relevant cation channel, whose activation is governed by specific ligand–pocket interactions. Methods: An integrated in silico workflow was employed, comprising structure-based docking, 100-nanosecond ...
Nicolás Ignacio Silva, Gianfranco Sabadini, David Cabezas, Cristofer González, Paulina González, Jiao Luo, Cristian O. Salas, Marco Mellado, Marcos Lorca, Javier Romero-Parra, Jaime Mella   +10 more
doaj   +2 more sources

A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies [PDF]

Molecules
In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu, Michela Begala, Maria João Matos, Davide Crucitti, Valeria Sogos, Benedetta Era, Antonella Fais   +6 more
doaj   +2 more sources

Synthesis of novel artesunate-benzothiophene and artemisinin-benzothiophene derivatives

Natural Product Research, 2021
Natural products are used for the treatment of a variety of diseases for many years. Last decades, design and synthesis of novel biologically active hybrid molecules including natural product is gained big importance due to their unique and new biological properties.
Omruye Ozok, Emrah Kavak, Arif Kivrak
openaire   +4 more sources

Benzothiophene Adsorptive Desulfurization onto trihexYl(tetradecyl)phosphonium Dicyanamide Ionic-Liquid-Modified Renewable Carbon: Kinetic, Equilibrium and UV Spectroscopy Investigations

Molecules, 2022
The negative environmental and industrial impacts of the presence of sulfur compounds such as benzothiophene in fuels have led to a greater interest in desulfurization research.
Mohamed A. Habila, Zied A. ALOthman, Monerah R. ALOthman, Mohammed Salah El-Din Hassouna   +3 more
doaj   +1 more source

Microwave-assisted synthesis of a MK2 inhibitor by Suzuki-Miyaura coupling for study in Werner syndrome cells [PDF]

, 2015
Microwave-assisted Suzuki-Miyaura cross-coupling reactions have been employed towards the synthesis of three different MAPKAPK2 (MK2) inhibitors to study accelerated aging in Werner syndrome (WS) cells, including the cross-coupling of a 2-chloroquinoline
Bagley, David Kipling, Irina Chuckowree, Jessica Dwyer, Kyriakis, Lee, Mark Bagley, Meyn, Mohammed Baashen, Terence Davis, Thannhauser   +10 more
core   +7 more sources