Results 1 to 10 of about 4,697 (116)

Structural elucidation and Hirshfeld surface analysis of a fused thiophene ester: methyl 3-[(naphtho[2,1-b]thiophen-5-yl)methyl]-1-benzothiophene-2-carboxylate [PDF]

Acta Crystallographica Section E: Crystallographic Communications
The title compound, C23H16O2S2, is a benzo[b]thiophene-2-carboxylate derivative and consists of naphthothiophene and benzothiophene moieties bridged by a methylene group.
Sekaran Ranjith, Ayyamperumal Nataraj, Kabali Divya Bharathi, Arasambattu K. Mohanakrishnan   +3 more
doaj   +2 more sources

Novel Insights on Benzo[b]thiophene Analogues for MAO-B Inhibition and Neuroprotection: Design, Synthesis, Molecular Modelling Studies and Biological Activity [PDF]

Antioxidants
Neurodegenerative disorders (NDs), such as Alzheimer’s disease and Parkinson’s disease (PD), represent a significant challenge for ageing populations, with their prevalence increasing worldwide.
Francesca Arrighi, Emanuela Berrino, Paolo Guglielmi, Simone Carradori, Guya Diletta Marconi, Jacopo Pizzicannella, Simone Guarnieri, Tiziano Tuccinardi, Giulio Poli, Federico Pepi, Anna Troiani, Chiara Salvitti, Alessia Di Noi, Michele Coluccia, Giorgio Buttitta, Virginia Pontecorvi, Arianna Granese, Paola Chimenti, Daniela Secci, Anel Petzer, Jacobus Petrus Petzer, Francesca Diomede   +21 more
doaj   +2 more sources

Structure-Guided Discovery of Benzoic-Acid-Based TRPC6 Ligands: An Integrated Docking, MD, and MM-GBSA SAR Study: Potential Therapeutic Molecules for Autism Spectrum Disorder [PDF]

Pharmaceuticals
Background: TRPC6 is recognized as a therapeutically relevant cation channel, whose activation is governed by specific ligand–pocket interactions. Methods: An integrated in silico workflow was employed, comprising structure-based docking, 100-nanosecond ...
Nicolás Ignacio Silva, Gianfranco Sabadini, David Cabezas, Cristofer González, Paulina González, Jiao Luo, Cristian O. Salas, Marco Mellado, Marcos Lorca, Javier Romero-Parra, Jaime Mella   +10 more
doaj   +2 more sources

A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies [PDF]

Molecules
In this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu, Michela Begala, Maria João Matos, Davide Crucitti, Valeria Sogos, Benedetta Era, Antonella Fais   +6 more
doaj   +2 more sources

Benzothiophene Adsorptive Desulfurization onto trihexYl(tetradecyl)phosphonium Dicyanamide Ionic-Liquid-Modified Renewable Carbon: Kinetic, Equilibrium and UV Spectroscopy Investigations

Molecules, 2022
The negative environmental and industrial impacts of the presence of sulfur compounds such as benzothiophene in fuels have led to a greater interest in desulfurization research.
Mohamed A. Habila, Zied A. ALOthman, Monerah R. ALOthman, Mohammed Salah El-Din Hassouna   +3 more
doaj   +1 more source

Hetero-Type Benzannulation Leading to Substituted Benzothio-Phenes

Molecules, 2021
TiCl4 (or SnCl4)-promoted hetero-type benzannulation reactions using various (2,2-dichlorocyclopropyl)(thiophen-2-yl)methanols proceeded smoothly to produce uniquely substituted 4-chlorobenzothiophenes (five examples).
Taro Kono, Ryosuke Sasaki, Hideki Goto, Masatoshi Kakuno, Yoo Tanabe   +4 more
doaj   +1 more source

Hydrodesulfurization of benzothiophene on Ni2P surface

Energy Exploration & Exploitation, 2020
The study of benzothiophene hydrodesulfurization reaction path contribute to clarifying the mechanism of hydrodesulfurization (HDS) of heavy oil. In this work, experiments and simulations were combined to study the reaction pathway of benzothiophene ...
Riyi Lin, Huida Pan, Weidong Xu, Liqiang Zhang, Xinwei Wang, Jianliang Zhang, Kai Chen   +6 more
doaj   +1 more source

Synthesis, Characterization and Biological Evaluation of Some Azo and Azo-Schiff Compounds [PDF]

Kirkuk Journal of Science, 2019
This work involves the preparation of some new azo and azo-Schiff compounds derived from benzothiophene, dibenzothiophene, and diamines (1, 5-diaminonaphthalene, and thiocarbohydrazide).
Hadi Azeez, Ahmed Al-kadhimi, Nashwan Tapabashi   +2 more
doaj   +1 more source

Et3N/DMSO-supported one-pot synthesis of highly fluorescent β-carboline-linked benzothiophenones via sulfur insertion and estimation of the photophysical properties

Beilstein Journal of Organic Chemistry, 2020
A robust transition-metal-free strategy is presented to access novel β-carboline-tethered benzothiophenone derivatives from 1(3)-formyl-β-carbolines using elemental sulfur activated by Et3N/DMSO.
Dharmender Singh, Vipin Kumar, Virender Singh   +2 more
doaj   +1 more source

Comparison of crystal structures of 4-(benzo[b]thiophen-2-yl)-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole and 4-(benzo[b]thiophen-2-yl)-2-methyl-5-(3,4,5-trimethoxyphenyl)-2H-1,2,3-triazole

Acta Crystallographica Section E, 2014
The title compound, C19H17N3O3S (I), was prepared by a [3 + 2]cycloaddition azide condensation reaction using sodium azide and l-proline as a Lewis base catalyst. N-Methylation of compound (I) using CH3I gave compound (II), C20H19N3O3S.
Narsimha Reddy Penthala, Nikhil Reddy Madadi, Shobanbabu Bommagani, Sean Parkin, Peter A. Crooks   +4 more
doaj   +1 more source