Structural elucidation and Hirshfeld surface analysis of a fused thiophene ester: methyl 3-[(naphtho[2,1-b]thiophen-5-yl)methyl]-1-benzothiophene-2-carboxylate [PDF]
Acta Crystallographica Section E: Crystallographic CommunicationsThe title compound, C23H16O2S2, is a benzo[b]thiophene-2-carboxylate derivative and consists of naphthothiophene and benzothiophene moieties bridged by a methylene group.
Sekaran Ranjith +3 more
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Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners
Molecules, 2017 Malaria is a severe and life-threatening disease caused by Plasmodium parasites that are spread to humans through bites of infected Anopheles mosquitoes.
Milica Selakovic +2 more
exaly +3 more sources
Novel Insights on Benzo[b]thiophene Analogues for MAO-B Inhibition and Neuroprotection: Design, Synthesis, Molecular Modelling Studies and Biological Activity [PDF]
AntioxidantsNeurodegenerative disorders (NDs), such as Alzheimer’s disease and Parkinson’s disease (PD), represent a significant challenge for ageing populations, with their prevalence increasing worldwide.
Francesca Arrighi +21 more
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Structure-Guided Discovery of Benzoic-Acid-Based TRPC6 Ligands: An Integrated Docking, MD, and MM-GBSA SAR Study: Potential Therapeutic Molecules for Autism Spectrum Disorder [PDF]
PharmaceuticalsBackground: TRPC6 is recognized as a therapeutically relevant cation channel, whose activation is governed by specific ligand–pocket interactions. Methods: An integrated in silico workflow was employed, comprising structure-based docking, 100-nanosecond ...
Nicolás Ignacio Silva +10 more
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A New Class of Benzo[b]thiophene-chalcones as Cholinesterase Inhibitors: Synthesis, Biological Evaluation, Molecular Docking and ADME Studies [PDF]
MoleculesIn this study, heterocyclic compounds containing a benzothiophene scaffold were designed and synthetized, and their inhibitory activity against cholinesterases (ChE) and the viability of SH-SY5Y cells have been evaluated.
Giovanna Lucia Delogu +6 more
doaj +2 more sources
Molecules, 2022 The negative environmental and industrial impacts of the presence of sulfur compounds such as benzothiophene in fuels have led to a greater interest in desulfurization research.
Mohamed A. Habila +3 more
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Synthesis of novel artesunate-benzothiophene and artemisinin-benzothiophene derivatives
Natural Product Research, 2021 Natural products are used for the treatment of a variety of diseases for many years. Last decades, design and synthesis of novel biologically active hybrid molecules including natural product is gained big importance due to their unique and new biological properties.
Omruye Ozok, Emrah Kavak, Arif Kivrak
openaire +4 more sources
Hetero-Type Benzannulation Leading to Substituted Benzothio-Phenes
Molecules, 2021 TiCl4 (or SnCl4)-promoted hetero-type benzannulation reactions using various (2,2-dichlorocyclopropyl)(thiophen-2-yl)methanols proceeded smoothly to produce uniquely substituted 4-chlorobenzothiophenes (five examples).
Taro Kono +4 more
doaj +1 more source
Hydrodesulfurization of benzothiophene on Ni2P surface
Energy Exploration & Exploitation, 2020 The study of benzothiophene hydrodesulfurization reaction path contribute to clarifying the mechanism of hydrodesulfurization (HDS) of heavy oil. In this work, experiments and simulations were combined to study the reaction pathway of benzothiophene ...
Riyi Lin +6 more
doaj +1 more source
Metal‐Free Arylation of Benzothiophenes at C4 by Activation as their Benzothiophene S‐Oxides
Angewandte Chemie International Edition, 2023 AbstractBenzothiophenes, activated by oxidation to the corresponding S‐oxides, undergo C−H/C−H‐type coupling with phenols to give C4 arylation products. While an electron‐withdrawing group at C3 of the benzothiophene is important, the process operates without a directing group and a metal catalyst, thus rendering it compatible with sensitive ...
Ranjana Bisht +6 more
openaire +3 more sources