Results 1 to 10 of about 7,478 (215)

Synthesis of novel artesunate-benzothiophene and artemisinin-benzothiophene derivatives

Natural Product Research, 2021
Natural products are used for the treatment of a variety of diseases for many years. Last decades, design and synthesis of novel biologically active hybrid molecules including natural product is gained big importance due to their unique and new biological properties.
Omruye Ozok, Emrah Kavak, Arif Kivrak
openaire   +6 more sources

Hydrodesulfurization of benzothiophene on Ni2P surface

Energy Exploration & Exploitation, 2020
The study of benzothiophene hydrodesulfurization reaction path contribute to clarifying the mechanism of hydrodesulfurization (HDS) of heavy oil. In this work, experiments and simulations were combined to study the reaction pathway of benzothiophene ...
Riyi Lin, Huida Pan, Weidong Xu, Liqiang Zhang, Xinwei Wang, Jianliang Zhang, Kai Chen   +6 more
doaj   +2 more sources

Discovery of a Novel Benzothiophene Inhibitor of Penicillin-Binding Protein 2 with Potent Gram-Positive Activity [PDF]

Antibiotics
Background/Objectives: The emergence of methicillin-resistant Staphylococcus aureus (MRSA) highlights the need for new antibacterial agents. Here, we report the identification and evaluation of a novel Gram-positive selective antibacterial: NDM-552 ...
Monica A. Stefaniak, Vijay Singh Gondil, Jingdong Yang, Adil Omar, Allen G. Oliver, Ansley M. Nemeth, Roberta J. Melander, Mayland Chang, Paul M. Dunman, Christian Melander   +9 more
doaj   +2 more sources

Benzothiophene Adsorptive Desulfurization onto trihexYl(tetradecyl)phosphonium Dicyanamide Ionic-Liquid-Modified Renewable Carbon: Kinetic, Equilibrium and UV Spectroscopy Investigations

Molecules, 2022
The negative environmental and industrial impacts of the presence of sulfur compounds such as benzothiophene in fuels have led to a greater interest in desulfurization research.
Mohamed A. Habila, Zied A. ALOthman, Monerah R. ALOthman, Mohammed Salah El-Din Hassouna   +3 more
doaj   +2 more sources

Structural elucidation and Hirshfeld surface analysis of a fused thiophene ester: methyl 3-[(naphtho[2,1-b]thiophen-5-yl)methyl]-1-benzothiophene-2-carboxylate [PDF]

Acta Crystallographica Section E: Crystallographic Communications
The title compound, C23H16O2S2, is a benzo[b]thiophene-2-carboxylate derivative and consists of naphthothiophene and benzothiophene moieties bridged by a methylene group.
Sekaran Ranjith, Ayyamperumal Nataraj, Kabali Divya Bharathi, Arasambattu K. Mohanakrishnan   +3 more
doaj   +2 more sources

Design, synthesis and structural mechanism of action of TRPV1 agonist MSP20 with long-lasting analgesic effect [PDF]

Nature Communications
Transient receptor potential vanilloid type-1 (TRPV1) channel is a polymodal receptor involved in pain perception and neuronal signalling that represents a promising target for the development of analgesics and neuroprotective agents.
Arthur Neuberger, Isabella Romeo, Francesca Aiello, Alexey Alekseev, Samuele Maramai, Federica Pessina, Chiara Vagaggini, Federica Poggialini, Elena Dreassi, Maria Frosini, Aniello Schiano Moriello, Luciano De Petrocellis, Andrea Maria Morace, Carmela Belardo, Michela Perrone, Roozbe Bonsale, Livio Luongo, Sabatino Maione, Irina A. Talyzina, Stefano Alcaro, Anna Artese, Antonella Brizzi, Alexander I. Sobolevsky   +22 more
doaj   +2 more sources

Novel Insights on Benzo[b]thiophene Analogues for MAO-B Inhibition and Neuroprotection: Design, Synthesis, Molecular Modelling Studies and Biological Activity [PDF]

Antioxidants
Neurodegenerative disorders (NDs), such as Alzheimer’s disease and Parkinson’s disease (PD), represent a significant challenge for ageing populations, with their prevalence increasing worldwide.
Francesca Arrighi, Emanuela Berrino, Paolo Guglielmi, Simone Carradori, Guya Diletta Marconi, Jacopo Pizzicannella, Simone Guarnieri, Tiziano Tuccinardi, Giulio Poli, Federico Pepi, Anna Troiani, Chiara Salvitti, Alessia Di Noi, Michele Coluccia, Giorgio Buttitta, Virginia Pontecorvi, Arianna Granese, Paola Chimenti, Daniela Secci, Anel Petzer, Jacobus Petrus Petzer, Francesca Diomede   +21 more
doaj   +2 more sources

Structure-Guided Discovery of Benzoic-Acid-Based TRPC6 Ligands: An Integrated Docking, MD, and MM-GBSA SAR Study: Potential Therapeutic Molecules for Autism Spectrum Disorder [PDF]

Pharmaceuticals
Background: TRPC6 is recognized as a therapeutically relevant cation channel, whose activation is governed by specific ligand–pocket interactions. Methods: An integrated in silico workflow was employed, comprising structure-based docking, 100-nanosecond ...
Nicolás Ignacio Silva, Gianfranco Sabadini, David Cabezas, Cristofer González, Paulina González, Jiao Luo, Cristian O. Salas, Marco Mellado, Marcos Lorca, Javier Romero-Parra, Jaime Mella   +10 more
doaj   +2 more sources

Hetero-Type Benzannulation Leading to Substituted Benzothio-Phenes

Molecules, 2021
TiCl4 (or SnCl4)-promoted hetero-type benzannulation reactions using various (2,2-dichlorocyclopropyl)(thiophen-2-yl)methanols proceeded smoothly to produce uniquely substituted 4-chlorobenzothiophenes (five examples).
Taro Kono, Ryosuke Sasaki, Hideki Goto, Masatoshi Kakuno, Yoo Tanabe   +4 more
doaj   +1 more source

Metal‐Free Arylation of Benzothiophenes at C4 by Activation as their Benzothiophene S‐Oxides

Angewandte Chemie International Edition, 2023
AbstractBenzothiophenes, activated by oxidation to the corresponding S‐oxides, undergo C−H/C−H‐type coupling with phenols to give C4 arylation products. While an electron‐withdrawing group at C3 of the benzothiophene is important, the process operates without a directing group and a metal catalyst, thus rendering it compatible with sensitive ...
Ranjana Bisht, Mihai V. Popescu, Zhen He, Ameer M. Ibrahim, Giacomo E. M. Crisenza, Robert S. Paton, David J. Procter   +6 more
openaire   +3 more sources