Results 11 to 20 of about 4,774 (187)
Antimalarials with Benzothiophene Moieties as Aminoquinoline Partners [PDF]
Molecules, 2017 Malaria is a severe and life-threatening disease caused by Plasmodium parasites that are spread to humans through bites of infected Anopheles mosquitoes.
Jelena Konstantinović +6 more
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Synthesis of novel artesunate-benzothiophene and artemisinin-benzothiophene derivatives
Natural Product Research, 2021 Natural products are used for the treatment of a variety of diseases for many years. Last decades, design and synthesis of novel biologically active hybrid molecules including natural product is gained big importance due to their unique and new biological properties.
Omruye Ozok, Emrah Kavak, Arif Kivrak
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Metal‐Free Arylation of Benzothiophenes at C4 by Activation as their Benzothiophene S‐Oxides
Angewandte Chemie International Edition, 2023 AbstractBenzothiophenes, activated by oxidation to the corresponding S‐oxides, undergo C−H/C−H‐type coupling with phenols to give C4 arylation products. While an electron‐withdrawing group at C3 of the benzothiophene is important, the process operates without a directing group and a metal catalyst, thus rendering it compatible with sensitive ...
Ranjana Bisht +6 more
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Streamlined Synthesis and Structure-Activity Relationship Analysis of 2-Amidothiophene-3-Carboxamides Targeting Influenza Polymerase PA-PB1 Heterodimerization. [PDF]
ChemMedChemDevelopment of a three‐step synthesis and replacement of the cycloheptyl moiety in cycloheptathiophene‐3‐carboxamide derivatives revealed how thiophene C‐5 substitutions modulate PA–PB1 inhibition, antiviral potency, and water solubility. The phenyl analog 9 delivered sub‐µM potency across multiple IV strains, while the methyl analog 5 achieved the ...
Felicetti T +8 more
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Angewandte Chemie International Edition, 2021 AbstractBenzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Herein, we report a general method for the synthesis of enantioenriched 2,3‐disubstituted benzothiophenes via a transition‐metal‐free C2‐alkylation of benzothiophenes with boronic esters.
Ruocheng Sang +2 more
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3-(4-Methoxybenzyl)-1-benzothiophene
Acta Crystallographica Section E, 2010 In the title compound, C16H14OS, the dihedral angle between the benzothiophene ring system and the benzene ring is 72.41 (12)°. A weak intermolecular C—H...π interaction from the benzene ring to the benzothiophene ...
B. Gunasekaran +4 more
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Beilstein Journal of Organic Chemistry, 2017 An efficient base-catalyzed protocol for the synthesis of benzothiophene is described. The reaction proceeds via base-promoted propargyl–allenyl rearrangement followed by cyclization and allyl migration.
Jinzhong Yao +4 more
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Química Nova, 2009 Desulphurization process by adsorption was studied employing a commercial diesel dooped with 1000 mg/L of benzothiophene and dibenzothiophene. The adsorbents materials employed were three types of activated alumina (acid, basic and neutral).
Robison P. Scherer +3 more
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Synthesis of Benzothiophene-Fused Pyran Derivatives via Piperidine Promoted Domino Reaction
Heteroatom Chemistry, 2019 A new domino reaction between thioaurones and malononitrile has been reported. This reaction allows efficient access to benzothiophene-fused pyran derivatives in good yields under mild reaction conditions.
Shihang Li +3 more
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3′-(4-Chlorophenyl)-4′-phenyl-3H,4′H-spiro[benzo[b]thiophene-2,5′-isoxazol]-3-one
IUCrData, 2017 The molecule of the title compound, C22H14ClNO2S, is built up from an isoxazole ring linked to a benzothiophene ring system with additional phenyl and 4-chlorophenyl substituents.
Mohamed Bakhouch +4 more
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