Thermal Decomposition of Diphenyl Tetroxane in Chlorobenzene Solution [PDF]
, 2019 The thermal decomposition of Cyclic Diperoxide of Benzaldehyde 3,6-diphenyl-1,2,4,5-tetroxane, (DFT) in chlorobenzene solution in the studied temperature range (130°C - 166°C) satisfactorily satisfies a first order law up to 60% conversions of diperoxide.
Bordón, Alexander Germán +6 more
core +1 more source
The activity of dispiro peroxides against Fasciola hepatica [PDF]
Bioorganic & Medicinal Chemistry Letters, 2011 Dispiro 1,2,4-trioxanes and 1,2,4,5-tetraoxanes had superior efficacy against Fasciola hepatica than the corresponding ozonides (1,2,4-trioxolanes). For highest efficacy, spiroadamantane and carboxymethyl substructures were required. Three compounds completely cured F.
Wang, Xiaofang +6 more
openaire +3 more sources
In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate [PDF]
, 2017 Recently published data suggest that artemisinin derivatives and synthetic peroxides, such as the ozonides OZ277 and OZ439, have a similar mode of action.
Benjamin Blasco +6 more
core +3 more sources
Efficient synthesis and antimicrobial evaluation of some Mannich bases from 2-arylidine-1-thia-4-azaspiro[4.5]decan-3-ones [PDF]
, 2015 BACKGROUND: Thiazolidinone, has been employed in the preparation of different important drugs required for treatment of inflammations, bacterial infections, and hypertension. Mannich bases have been shown to exhibit diverse biological activities, such as
Essam M Hussein +2 more
core +1 more source
Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides
Bioorganic & Medicinal Chemistry Letters, 2007 Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
Tang, Yuanqing +15 more
openaire +4 more sources
Scientific Reports, 2022 A series of 1″-(alkylsulfonyl)-dispiro[indoline-3,2′-pyrrolidine-3′,3″-piperidine]-2,4″-diones 6a‒o has been synthesized through regioselective multi-component azomethine dipolar cycloaddition reaction of 1-(alkylsulfonyl)-3,5-bis(ylidene)-piperidin-4 ...
Nehmedo G. Fawazy +13 more
doaj +1 more source
Room Temperature Synthesis and Antibacterial Activity of New Sulfonamides Containing N,N -Diethyl-Substituted AmidoMoieties [PDF]
, 2012 Sulfonamide drugs which have brought about an antibiotic revolution in medicine are associated with a wide range of biological activities.
Ajani, Olayinka O. +4 more
core +5 more sources
Stereoselective Synthesis of Novel Dispiro Oxindole-pyrrolothiazole-androsterone Hybrids [PDF]
Synthetic Communications, 2014 A facile synthesis of novel dispiro oxindole-pyrrolothiazole-androsterone hybrid heterocycles has been achieved through 1,3-dipolar cycloaddition. The reaction proceeds stereo- and regioselectively, affording a single isomer of the product in excellent yields with the formation of two C–C and one C–N bonds and creation of four new contiguous ...
Selvaraj Kanchithalaivan +2 more
openaire +1 more source
Design, synthesis, and antitumor activity of novel dispiro[oxindole-cyclohexanone]-pyrrolidines [PDF]
, 2022 Background: Spirooxindoles are privileged scaffolds in medicinal chemistry, which were identified through Wang’s pioneering work as inhibitors of MDM2-p53 interactions.
Azab, Mohamed +7 more
core +2 more sources
Competitive formation of spiro and ansa derivatives in the reactions of tetrafluorobutane-1,4-diol with hexachlorocyclotriphosphazene: a comparison with butane-1,4-diol [PDF]
, 2006 Reaction of hexachlorocyclotriphosphazene, N3P3Cl6 (1), in two stoichiometries (1:1.2 and 1:3) with the sodium derivative of the fluorinated diol, 2,2,3,3-tetrafluorobutane-1,4-diol, (2), in THF solution at room temperature afforded six products, whose ...
Beşli, S. +5 more
core +1 more source