Results 51 to 60 of about 1,879 (233)

Molecular and Crystal Structure, Spectroscopy, and Photochemistry of a Dispiro Compound Bearing the Tetraoxane Pharmacophore.

Chemistry, 2023
The molecular structure and photochemistry of dispiro[cyclohexane-1,3'-[1,2,4,5]tetraoxane-6',2''-tricyclo[3.3.1.13,7]decan]-4-one (TX), an antiparasitic 1,2,4,5-tetraoxane, was investigated using matrix isolation IR and EPR spectroscopies, and quantum ...
Patrícia S. M. Amado, Susy Lopes, Elisa M. Brás, J. A. Paixão, Machiko Takano, M. Abe, R. Fausto, M. L. Cristiano   +7 more
semanticscholar   +1 more source

Spiro[3.3]heptane: A Versatile sp3‐Rich Scaffold and its Synthetic Routes

European Journal of Organic Chemistry, Volume 28, Issue 43, November 24, 2025.
The sp3‐rich spiro[3.3]heptane scaffold is a saturated, 3D bioisostere of benzene. This review summarizes key synthetic strategies, including [2+2] cyclizations and bond disconnections at C1C2 or C4 (spiro‐carbon) positions, offering a practical guide for accessing this emerging motif and expanding drug‐like chemical space.
Myunggi Jung
wiley   +1 more source

Synthesis of Benzodithieno[5.5.5.6]Fenestranes: Unexpected Epimerization and Regiochemical Outcomes

Asian Journal of Organic Chemistry, Volume 14, Issue 7, July 2025.
Isomeric [5.5.5.6]fenestranes annulated with one benzene and two thiophene rings are accessible via di‐2‐ and di‐3‐thienylspirane intermediates. The key double cyclization step involves surprising stereoselectivity and regioselectivity. In particular, cis‐di(2‐thienyl)spirane precursors lead to the all‐cis‐fenestrane skeleton by an unexpected acid ...
Björn Bredenkötter, Wai‐Shing Wong, Man‐Kit Lee, Chun‐Fai Ng, Hak‐Fun Chow, Dietmar Kuck   +5 more
wiley   +1 more source

Elucidation of the activity, pharmacokinetics, and toxicity profiles of fasciocidal drug candidates 1,2,4-trioxolane OZ78 and 1,2,4,5-tetraoxane MT04 [PDF]

, 2012
: Fascioliasis is a disease belonging to the most neglected tropical diseases. Causative agents are the food borne trematodes Fasciola hepatica and Fasciola gigantica, whereas F. hepatica is especially of human concern. F. hepatica and F.
Kirchhofer, Carla Martina
core   +1 more source

9,10-Dihydrophenanthrene with Two Spiro(dibenzocycloheptatriene) Units: A Highly Strained Caged Hydrocarbon Exhibiting Reversible Electrochromic Behavior

Molecules, 2017
The title dispiro hydrocarbon 1 was designed as a new electrochromic material. This multiply clamped hexaphenylethane-type electron donor was prepared from 2,2’-diiodobiphenyl via biphenyl-2,2’-diylbis(dibenzotropylium) 22+ salt.
Yusuke Ishigaki, Yuki Hayashi, Kazuma Sugawara, Takuya Shimajiri, Wataru Nojo, Ryo Katoono, Takanori Suzuki   +6 more
doaj   +1 more source

Photooxygenation Reactions of Olefins Under Flow Conditions: An Experimental and In‐Silico Study

ChemPhotoChem, Volume 9, Issue 6, June 2025.
This study focuses on the setup and validation of the oxygenation reaction of alkenes to 1,2‐dioxetanes and hydroperoxides by a LED‐driven flow chemistry approach. An in‐silico a model was trained on reaction data that can tailor a specific chemical scope through fine‐tuning.
Giada Moroni, Yi‐Hsuan Tsai, Marco Ballarotto, Andrea Carotti, Jean‐Christophe M. Monbaliu, Antimo Gioiello   +5 more
wiley   +1 more source

An expeditious and environmentally benign synthesis of dispiro-3-phenylpyrrolothiazoles in ACI/EG eutectic mixture and its antioxidant and antimicrobial activities against urinary tract pathogens

BMC Chemistry, 2019
The present study reveals the robust and facile methodology for the synthesis of massively selective dispiro-3-phenylpyrrolothiazole hybrids via one-pot 1,3-dipolar cycloaddition reaction by environmentally supported solvents and to evaluate their ...
Govindasami Periyasami, Karuppiah Ponmurugan, Natarajan Arumugam, Raju Sureshkumar, Mostafizur Rahaman, Durairaju Periyan, Naif Abdullah Al-Dhabi, Shaykha Alzahly, Ali Aldalbahi   +8 more
doaj   +1 more source

Reaction of the Diferrocenylphosphenium Ion with Diphenylacetylene and 2,3‐Dimethyl‐1,3‐Butadiene

Zeitschrift für anorganische und allgemeine Chemie, Volume 651, Issue 8, May 28, 2025.
The cycloaddtion reactions of the title compounds quantitatively provided new phosphirenium and 3‐phospholenium ions. The reaction of the diferrocenylphosphenium ion, [Fc2P][B(C6F5)4] with diphenylacetylene and 2,3‐dimethyl‐1,3‐butadiene, gives rise to the quantitative formation of the phosphirenium ion [Fc2P(CPh)2][B(C6F5)4] (1) and the 3 ...
Corina Stoian, Sergey Ketkov, Jens Beckmann   +2 more
wiley   +1 more source

Synthesis and the Spectral Investigations of Spiro, Ansa and Bridged Derivatives of Cyclochlorotriphosphazenes

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2011
The reactions of hexachlorocyclotriphosphazatriene, N3P3Cl6 (1) with 2,2-dimethylpropane-1,3-diol yield 9 new cyclophosphazene derivatives. One monospiro, N3P3Cl4[(OCH2)2-CMe2], dispiro, N3P3Cl2[(OCH2)2-CMe2]2 and tris-spiro N3P3[(OCH2)2-CMe2]3 ...
Sedat Ture
doaj   +1 more source

Reactions of cyclochlorotriphosphazatriene with 1-amino-2-propanol. Calorimetric and spectroscopic investigations of the derived products

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 2018
Reactions of hexachlorocyclotriphosphazatriene,N3P3Cl6 (1)with 1-amino-2-propanol (2), in(1:1:2, 1:2:4 and 1:3:6) mole ratios, in excess of NaH, in THF and acetonitril solutionsyield a total of 6 novel products:onemono-open chain, N3P3Cl5[HN-CH2-CH(CH3 ...
Murat Tuna, Rafig Gurbanov, Sedat Türe
doaj   +1 more source