Results 51 to 60 of about 161 (128)

Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases

Molecules, 2013
We synthesized two series of androstane derivatives as inhibitors of type 3 and type 5 17β-hydroxysteroid dehydrogenases (17β-HSDs). In the first series, four monospiro derivatives at position C17 were prepared from androsterone (ADT ...
Donald Poirier, Jenny Roy, Béatrice Tchédam Ngatcha, Guy Bertrand Djigoué   +3 more
doaj   +1 more source

Hydrindacene‐Based Zinc Aryl Thiolate and Aryl Selenolate Zn(EMSFluind)2 (E=S, Se)

Zeitschrift für anorganische und allgemeine Chemie, Volume 650, Issue 9-10, May 17, 2024.
The bulky s‐hydrindacene‐based MSFluind substituent was used to generate thiol 1S and selenol 1Se and the corresponding zinc aryl thiolate 2S and selenolate 2Se, all of which were structurally characterized using single crystal XRD. Abstract The bulky aryl thiol, MSFluindSH (1S), and aryl selenol, MSFluindSeH (1Se), possessing a tetramethyl‐s ...
Pascal Komorr, Pim Puylaert, Jens Beckmann   +2 more
wiley   +1 more source

Crystal structures of two 2,9-dithia-13-azadispiro[4.1.47.35]tetradecan-6-ones

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compounds 4,11-dihydroxy-13-methyl-1,8-di-p-tolyl-2,9-dithia-13- azadispiro[4.1.47.35]tetradecan-6-one, C26H31NO3S2, (I), and 13-benzyl-4,11-dihydroxy-1,8-bis(4-methylphenyl)-2,9-dithia-13-azadispiro[4.1.47.35]tetradecan-6-one, C32H35NO3S2, (
Vijayan Viswanathan, Shanmugavel Bharkavi, Subbu Perumal, Devadasan Velmurugan   +3 more
doaj   +1 more source

Dispiro[cyclopropane-1,5′-endo-tricyclo[5.2.1.02,6]deca-3,8-diene-10′,1′′-cyclopropane]

Acta Crystallographica Section E, 2010
The title compound, C14H16, is built up from three five-membered rings. Two of the five-membered rings display an envelope conformation and the third one is almost planar (r.m.s. deviation = 0.014 Å).
Rafał Grubba, Łukasz Ponikiewski, Jerzy Pikies   +2 more
doaj   +1 more source

Isolation of kinetically-stabilised diarylchalcogenide radical cations

Communications Chemistry
Chalcogenide radical cations [R2E]•+ (E = S, Se, Te) are commonly short-lived intermediates of fundamental interest. Sulfide radical cations in particular are associated in vivo with oxidative stress and neuropathological processes.
Pascal Komorr, Corina Stoian, Aleksa Radović, Björn A. Meyer, Pim Puylaert, George E. Cutsail III, Emanuel Hupf, Jens Beckmann   +7 more
doaj   +1 more source

Crystal structure of ethyl (2S,2′R)-1′-benzyl-3-oxo-3H-dispiro[1-benzothiophene-2,3′-pyrrolidine-2′,11′′-indeno[1,2-b]quinoxaline]-4′-carboxylate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C35H27N3O3S, the spiro-linked five-membered rings both adopt twisted conformations. The pyrrolidine ring makes dihedral angles of 80.5 (1) and 77.4 (9)° with the benzothiophene ring system and the quinoxaline ring system ...
J. Govindaraj, R. Raja, M. Suresh, R. Raghunathan, A. SubbiahPandi   +4 more
doaj   +1 more source

Crystal structure of 1′,1′′-dimethyl-4′-(4-cholorophenyl)dispiro[11H-indeno[1,2-b]quinoxaline-11,2′-pyrrolidine-3′,3′′-piperidin]-4′′-one

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the title compound, C30H27ClN4O, the central pyrrolidine ring adopts an envelope conformation with the methylene C atom being the flap. The quinoxaline and indane rings are each essentially planar, with r.m.s. deviations of 0.027 (1) and 0.0417 (1) Å,
R.A. Nagalakshmi, J. Suresh, K. Malathi, R. Ranjith Kumar, P. L. Nilantha Lakshman   +4 more
doaj   +1 more source

Weak base dispiro-1,2,4-trioxolanes: Potent antimalarial ozonides

Bioorganic & Medicinal Chemistry Letters, 2007
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
Tang, Yuanqing, Dong, Yuxiang, Wittlin, Sergio, Charman, Susan A., Chollet, Jacques, Chiu, Francis C. K., Charman, William N., Matile, Hugues, Urwyler, Heinrich, Dorn, Arnulf, Bajpai, Saroj, Wang, Xiaofang, Padmanilayam, Maniyan, Karle, Jean M., Brun, Reto, Vennerstrom, Jonathan L.   +15 more
openaire   +3 more sources

syn-Dispiro[1,3-dioxolane-2,17′-pentacyclo[12.2.1.16,9.02,13.05,10]octadecane-18′,2′′-[1,3]dioxolane]-7′,15′-diene

Acta Crystallographica Section E, 2010
The title compound, C22H28O4, is composed of a central octadecane ring and two spiro[bicyclo[2.2.1]hept[2]ene-7,2′-[1,3]dioxolane] units.
Rulla M. Kachlan, Macey C. Ruble, Jacob C. Timmerman, Markus Etzkorn, Daniel S. Jones   +4 more
doaj   +1 more source

1′,1′′-Dimethyl-4′-(4-methylphenyl)dispiro[11H-indeno[1,2-b]quinoxaline-11,2′-pyrrolidine-3′,3′′-piperidin]-4′′-one

Acta Crystallographica Section E, 2013
In the title compound, C31H30N4O, the central pyrrolidine ring adopts an envelope conformation with the methylene C atom being the flap. The quinoxaline and indane rings are each planar, having r.m.s.
R. A. Nagalakshmi, J. Suresh, K. Malathi, R. Ranjith Kumar, P. L. N. Lakshman   +4 more
doaj   +1 more source