Results 51 to 60 of about 1,947 (193)

Photorearrangements in spiro-conjoined cyclohexa-2,5-dien-1-one [PDF]

, 2011
The unexpected formation of cyclohexa-2,5-dien-1-one (6) spiro-conjoined with a dihydrobenzofuran framework, and the photochemical behavior of this compound in solution as well as in the solid state are described.
上本, 紘平, 今井, 一則, 小林, 啓二, 有田, 敦子, 植草, 秀裕, 若林, 英嗣, 鈴木, 雅也   +6 more
core   +1 more source

An effective one-pot access to polynuclear dispiroheterocyclic structures comprising pyrrolidinyloxindole and imidazothiazolotriazine moieties via a 1,3-dipolar cycloaddition strategy

Beilstein Journal of Organic Chemistry, 2016
An effective and highly regio- and diastereoselective one-pot method for the synthesis of new polynuclear dispiroheterocyclic systems with five stereogenic centers (dispiro[imidazo[4,5-e]thiazolo[3,2-b]-1,2,4-triazine-6,3′-pyrrolidine-2′,3′′-indoles ...
Alexei N. Izmest’ev, Galina A. Gazieva, Natalya V. Sigay, Sergei A. Serkov, Valentina A. Karnoukhova, Vadim V. Kachala, Alexander S. Shashkov, Igor E. Zanin, Angelina N. Kravchenko, Nina N. Makhova   +9 more
doaj   +1 more source

Photolysis of Dispiro-substituted 3-Thioxo-1-cyclobutanones [PDF]

Bulletin of the Chemical Society of Japan, 1981
Abstract Photolysis of dispiro-substituted 3-thioxo-1-cyclobutanones in dichloromethane or even in methanol gave rise to the photoisomerization to afford thiolactones preferentially.
Koji Kimura, Yoshihiro Fukuda, Toshihiko Negoro, Yoshinobu Odaira   +3 more
openaire   +1 more source

Synthesis of 1-azaspiro[4.4]nonan-1-oxyls via intramolecular 1,3-dipolar cycloaddition

Beilstein Journal of Organic Chemistry, 2019
Sterically shielded nitroxides of the pyrrolidine series have shown the highest resistance to reduction. Here we report the synthesis of new pyrrolidine nitroxides from 5,5-dialkyl-1-pyrroline N-oxides via the introduction of a pent-4-enyl group to the ...
Yulia V. Khoroshunova, Denis A. Morozov, Andrey I. Taratayko, Polina D. Gladkikh, Yuri I. Glazachev, Igor A. Kirilyuk   +5 more
doaj   +1 more source

Examination of the Cytotoxic and Embryotoxic Potential and Underlying Mechanisms of Next-Generation Synthetic Trioxolane and Tetraoxane Antimalarials [PDF]

, 2012
Semisynthetic artemisinin-based therapies are the first-line treatment for P. falciparum malaria, but next-generation synthetic drug candidates are urgently required to improve availability and respond to the emergence of artemisinin-resistant parasites.
AC Beekman, AE Mercer, AE Mercer, Amy E. Mercer, Andreia D. Bringela, B. Kevin Park, Bob van de Water, Bram Herpers, CW Jefford, D Cardi, DA New, DP Williams, F Bousejra-El Garah, Gail Donegan, GL Disbrow, GL Firestone, Ian M. Copple, J Fishwick, J Hou, James Chadwick, James Firman, JC Puigvert, M Desai, M Kaiser, M Longo, M Longo, MA Fugi, Maria L. S. Cristiano, Michael H. L. Wong, NA Brown, NH Hunt, OW Griffith, P Olliaro, PA Stocks, Paul M. O’Neill, PD Brown-Woodman, PM O’Neill, PM O’Neill, RK Haynes, RK Haynes, RK Haynes, RL Clark, S D’Alessandro, S Krishna, S Toovey, SA Charman, Stephen A. Ward, T Efferth, WHO, WHO, X Gao, Y Dong   +51 more
core   +1 more source

The Diarylprolinol Silyl Ethers: After 20 Years Still Opening New Doors in Asymmetric Catalysis

Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.
Catalysis Rules! The year 2025 marks the 20th anniversary of diarylprolinol silyl ethers in asymmetric organocatalysis. During the first decade after their discovery, these catalysts have been established as one of the most versatile tools in aminocatalysis. Although now considered mature, recent years have witnessed renewed innovation.
Enrico Marcantonio, René Slot Bitsch, Karl Anker Jørgensen   +2 more
wiley   +1 more source

Pharmacological and pharmacokinetic studies on trematocidal drugs : praziquantel and two synthetic peroxide lead candidates [PDF]

, 2015
Trematodiases affect more than 250 million people worldwide, while the economic impact through veterinary infections is also colossal. Treatment options are however limited to two main drugs, triclabendazole for the liver fluke Fasciola hepatica, and ...
Meister, Isabel
core   +1 more source

Spiro[3.3]heptane: A Versatile sp3‐Rich Scaffold and its Synthetic Routes

European Journal of Organic Chemistry, Volume 28, Issue 43, November 24, 2025.
The sp3‐rich spiro[3.3]heptane scaffold is a saturated, 3D bioisostere of benzene. This review summarizes key synthetic strategies, including [2+2] cyclizations and bond disconnections at C1C2 or C4 (spiro‐carbon) positions, offering a practical guide for accessing this emerging motif and expanding drug‐like chemical space.
Myunggi Jung
wiley   +1 more source

Synthesis of Benzodithieno[5.5.5.6]Fenestranes: Unexpected Epimerization and Regiochemical Outcomes

Asian Journal of Organic Chemistry, Volume 14, Issue 7, July 2025.
Isomeric [5.5.5.6]fenestranes annulated with one benzene and two thiophene rings are accessible via di‐2‐ and di‐3‐thienylspirane intermediates. The key double cyclization step involves surprising stereoselectivity and regioselectivity. In particular, cis‐di(2‐thienyl)spirane precursors lead to the all‐cis‐fenestrane skeleton by an unexpected acid ...
Björn Bredenkötter, Wai‐Shing Wong, Man‐Kit Lee, Chun‐Fai Ng, Hak‐Fun Chow, Dietmar Kuck   +5 more
wiley   +1 more source

Humans from Wuchereria bancrofti endemic area elicit substantial immune response to proteins of the filarial parasite Brugia malayi and its endosymbiont Wolbachia [PDF]

, 2017
Detailed information of the individuals of bancroftian filariasis endemic area participated in the current study.
Anand Setty Balakrishnan, Dhanvantri Chahar, Mahendra Pal Singh Negi, Mamta Gangwar, Ruchi Jha, Shailja Misra-Bhattacharya   +5 more
core   +4 more sources