Protein and cell patterning in closed polymer channels by photoimmobilizing proteins on photografted poly(ethylene glycol) diacrylate [PDF]
, 2014 Definable surface chemistry is essential for many applications of microfluidic polymer systems. However, small cross-section channels with a high surface to volume ratio enhance passive adsorption of molecules that depletes active molecules in solution ...
Larsen, Esben Kjær Unmack +2 more
core +1 more source
A rapid, sensitive colorimetric assay for the high-throughput screening of transaminases in liquid or solid-phase [PDF]
, 2015 A new colorimetric method has been developed to screen transaminases using an inexpensive amine donor. The assay is sensitive, has a low level of background coloration, and can be used to identify and profile transaminase activities against aldehyde and ...
Baud, D +4 more
core +1 more source
Quilamine HQ1-44, an iron chelator vectorized toward tumor cells by the polyamine transport system, inhibits HCT116 tumor growth without adverse effect [PDF]
, 2015 International audienceTumor cell growth requires large iron quantities and the deprivation of this metal induced by synthetic metal chelators is therefore an attractive method for limiting the cancer cell proliferation.
Cannie, Isabelle +7 more
core +3 more sources
Medicinal Research Reviews, EarlyView.ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur +6 more
wiley +1 more source
Engineered C–N Lyases for Stereoselective Synthesis of Tertiary Amines
Angewandte Chemie, Volume 137, Issue 34, August 18, 2025.EDDS lyase was subjected to iterative cycles of site‐saturation mutagenesis and screened for increased activity for the addition of 2‐((methylamino)methyl)aniline to fumarate. The final mutant, EDDS lyase CEA, accepts various N‐methyl‐1‐phenylmethanamines derivatives, yielding N,N‐disubstituted L‐aspartic acids, as well as several ortho‐substituted ...
Laura Bothof +4 more
wiley +2 more sources
Biocatalytic behaviour of immobilized Rhizopus oryzae lipase in the 1,3-selective ethanolysis of sunflower oil to obtain a biofuel similar to biodiesel [PDF]
, 2016 A new biofuel similar to biodiesel was obtained in the 1,3-selective transesterification reaction of sunflower oil with ethanol using as biocatalyst a Rhizopus oryzae lipase (ROL) immobilized on Sepiolite, an inorganic support.
Bautista, Felipa M. +7 more
core +1 more source
11CO2 Fixation: A Renaissance in PET Radiochemistry [PDF]
, 2013 Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide.
Collier, Thomas L +6 more
core +1 more source
Synthesis of Versatile DNA‐Conjugated Aldehydes by Controlled Oxidation of Amines
Angewandte Chemie, Volume 137, Issue 32, August 4, 2025.A controlled oxidation strategy enables efficient in situ generation of aldehyde‐functionalized DNAs from DNA‐conjugated amines using O2/laccase/TEMPO. This approach facilitates reversible amine–aldehyde transformations for DNA bioconjugation, and provides access to chemically diverse DNA‐encoded libraries, broadening the toolbox for chemical biology ...
Guixian Zhao +6 more
wiley +2 more sources
PET studies of the serotonin system in major depression and its treatment [PDF]
, 2014 The serotonin system has been implicated in major depression since the 1960s, mainly based on the serotonin enhancing properties of antidepressants.
Tiger, Mikael
core +1 more source
An integrated approach with new strategies for QSAR models and lead optimization [PDF]
, 2017 Compound testing set for huAChE collected from Guo et al.
Hui-Hui Hsu +3 more
core +2 more sources