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Pharmacokinetic Comparisons of Bepotastine Besilate and Bepotastine Salicylate in Healthy Subjects
Clinical Drug Investigation, 2013Bepotastine is a second-generation histamine H(1) receptor antagonist that is indicated in allergic rhinitis, urticaria, and pruritus associated with skin disease. The aim of the present study was to compare the pharmacokinetics of two different bepotastine formulations [bepotastine besilate 10 mg (reference) and bepotastine salicylate 9.64 mg (test)],
Kyoung-Ah, Kim, Ji-Young, Park
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Bepotastine besilate for the treatment of pruritus
Expert Opinion on Pharmacotherapy, 2013Bepotastine besilate 1.5% is a newly approved second-generation topical antihistamine indicated for the pruritus associated with allergic conjunctivitis. In Japan, the oral formulation is approved to manage pruritus associated with allergic rhinitis and urticaria.Bepotastine is a piperidine derivative that antagonizes H1 receptors with high selectivity.
Leonard, Bielory +2 more
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Drug Development and Industrial Pharmacy, 2012
To develop a novel salt form of bepotastine with bioequivalent to the commericial bepostastine besilate, bepostastine salicylate was prepared and its physicochemical properties were investigated. Furthermore, the bepotastine salicylate-loaded tablet was prepared by the wet granulation method, and the dissolution and bioavailability in beagle dogs were ...
Kwan Hyung, Cho, Han-Gon, Choi
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To develop a novel salt form of bepotastine with bioequivalent to the commericial bepostastine besilate, bepostastine salicylate was prepared and its physicochemical properties were investigated. Furthermore, the bepotastine salicylate-loaded tablet was prepared by the wet granulation method, and the dissolution and bioavailability in beagle dogs were ...
Kwan Hyung, Cho, Han-Gon, Choi
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New drugs: Asenapine, iloperidone, and bepotastine besilate
Journal of the American Pharmacists Association, 2010Antipsychotic agents Asenapine (Saphris—Schering) and iloperidone (Fanapt—Vanda) are new atypical antipsychotic agents that join an already large class of these drugs that includes aripiprazole (Abilify), clozapine (e.g., Clozaril), olanzapine (Zyprexa), quetiapine (Seroquel), ziprasidone (Geodon), and risperidone (e.g., Risperdal) and its active ...
Daniel A, Hussar, Cheryl A, Abbas
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Effects of Bepotastine and Fexofenadine on Histamine-Induced Flare, Wheal and Itch
International Archives of Allergy and Immunology, 2012<i>Background:</i> Urticaria is mainly caused by mast cell-derived histamine through the histamine H<sub>1</sub> receptor. Antihistamines are occasionally used on demand upon a recurrence of urticaria; therefore, rapidly acting agents should be explored.
Hideaki, Tanizaki +4 more
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A Novel Synthetic Method for Bepotastine, a Histamine H1 Receptor Antagonist
Bulletin of the Korean Chemical Society, 2013 An efficient and alternative synthesis of enantiomerically pure (+)-(S)-4-(4-((4-chlorophenyl)(pyrid-2-yl)methoxy]piperidin-1-yl)butanoic acid, bepotastine (1) is described. The key resolution of (R/S)-bepotastine l-menthyl ester (3) is achived via diastereomeric salt crystallization using N-benzyloxycarbonyl-L-aspartic acid (NCbzLAA) as the resolving ...
Tae Hee Ha, Kwee-Hyun Suh, Gwan Sun Lee
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Applied Microbiology and Biotechnology, 2021
(S)-4-Chlorophenylpyridylmethanol and (R)-4-chlorobenzhydrol are key pharmaceutical intermediates for the synthesis of bepotastine and cloperastine, respectively. However, the biocatalytic approach to prepare these bulky diaryl ketones remains challenging because of the low activity of naturally occurring alcohol dehydrogenases (ADH).
Kai Wu +8 more
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(S)-4-Chlorophenylpyridylmethanol and (R)-4-chlorobenzhydrol are key pharmaceutical intermediates for the synthesis of bepotastine and cloperastine, respectively. However, the biocatalytic approach to prepare these bulky diaryl ketones remains challenging because of the low activity of naturally occurring alcohol dehydrogenases (ADH).
Kai Wu +8 more
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences), 2019
Kohji Naora +2 more
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Kohji Naora +2 more
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Journal of Toxicology and Environmental Health, Part A, 2014
Bepotastine salts (nicotinate and salicylate) were investigated for their physicochemical properties to develop novel salt forms of bepotastine, bioequivalent to the bepotastine besilate-loaded tablet (Talion). These bepotastine salts of either nicotinate- or salicylate-loaded tablets were prepared by conventional wet granulation method, and ...
Duck Soo, Lim +11 more
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Bepotastine salts (nicotinate and salicylate) were investigated for their physicochemical properties to develop novel salt forms of bepotastine, bioequivalent to the bepotastine besilate-loaded tablet (Talion). These bepotastine salts of either nicotinate- or salicylate-loaded tablets were prepared by conventional wet granulation method, and ...
Duck Soo, Lim +11 more
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Drug Research, 2019
AbstractBepotastine besilate (here after referred to as BTST), chemically known as ({d(S)4[4[(4chlorophenyl) (2pyridyl) methoxy] piperidino} butyric acid monobenzene sulphonate), is a second-generation antihistamine drug. To the best of our knowledge, no studies concerning the isolation or identification of process-related impurities have been reported
Chaowei, Zhang +4 more
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AbstractBepotastine besilate (here after referred to as BTST), chemically known as ({d(S)4[4[(4chlorophenyl) (2pyridyl) methoxy] piperidino} butyric acid monobenzene sulphonate), is a second-generation antihistamine drug. To the best of our knowledge, no studies concerning the isolation or identification of process-related impurities have been reported
Chaowei, Zhang +4 more
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