Results 151 to 160 of about 286,795 (334)

Circumventing glioblastoma resistance to temozolomide through optimal drug combinations designed by systems pharmacology and machine learning

British Journal of Pharmacology, EarlyView.
Background and Purpose Glioblastoma (GBM), the most frequent and aggressive brain tumour in adults, is associated with a dismal prognostic despite intensive treatment involving surgery, radiotherapy and temozolomide (TMZ)‐based chemotherapy. The initial or acquired resistance of GBM to TMZ appeals for precision medicine approaches to the design of ...
Sergio Corridore, Maïté Verreault, Hugo Martin, Thibault Delobel, Cécile Carrère, Ahmed Idbaih, Annabelle Ballesta   +6 more
wiley   +1 more source

Impacts of noise and interference on the bit error rate of the FBMC-OQAM modulation scheme in 5G systems

Российский технологический журнал
Objectives. The work sets out to evaluate the noise immunity of the signal modulation method in 5G networks using a filter bank multicarrier with offset quadrature amplitude modulation (FBMC-OQAM) and to analyze the bit error rate (BER).Methods.
A. Androon, O. V. Tikhonova
doaj   +1 more source

�ber de la Vall�e Poussins Ober-und Unterfunktionen einfacher Integrale und die Integraldefinition von Perron [PDF]

, 1921
Heinrich Hake
openalex   +1 more source

RBM39 Promotes Base Excision Repair to Facilitate the Progression of HCC by Stabilising OGG1 mRNA

Cell Proliferation, EarlyView.
Targeting RBM39 attenuates BER via destabilising OGG1 mRNA and potentiates KBrO3‐induced oxidative stress in HCC. Our study represents a valuable treatment strategy combining indisulam and an oxidative stress inducer in HCC. ABSTRACT Targeting base excision repair (BER) has been an attractive strategy in cancer therapeutics.
Hongda An, Anliang Xia, Siyuan Liu, Dongjun Luo, Longpo Geng, Binghua Li, Beicheng Sun, Zhu Xu   +7 more
wiley   +1 more source

�ber den Mechanismus der lichtelektrischen Leitf�higkeit [PDF]

, 1921
B. Gudden, R. O. Pohl
openalex   +1 more source

A steric gate prevents mutagenic dATP incorporation opposite 8‐oxo‐deoxyguanosine in mitochondrial DNA polymerases

The FEBS Journal, EarlyView.
Reactive oxygen species induce mutagenic DNA lesions, such as 8‐oxo‐2′‐deoxyguanosine (8‐oxodG), which acts as a template for dCMP and dAMP incorporation through its anti and syn conformations. Specific residues must regulate the fidelity of templated 8‐oxodG.
Noe Baruch‐Torres, Carlos H. Trasviña‐Arenas, Alexandru Ionut Gilea, Upeksha C. Dissanayake, Missael Molina‐Jiménez, Paola L. García‐Medel, Corina Díaz‐Quezada, Tiziana Lodi, G. Andrés Cisneros, Enrico Baruffini, Luis G. Brieba   +10 more
wiley   +1 more source

Performance analysis of nonlinear crosstalk of WDM systems using modulation schemes criteria

Open Engineering
Nonlinearities in optical fibers are regarded as the most significant barriers that endanger the effectiveness of the optical transmission system and pose a threat to communication quality.
Mohammed Nidhal Abd, Mansoor Riyadh, Abd Haider J., Fadhil Hilal A.   +3 more
doaj   +1 more source

�ber die Geschwindigkeit der Zersetzung des Ozons in w�sseriger L�sung [PDF]

, 1913
V. Rothmund, A. Burgstaller
openalex   +1 more source

Transcription‐coupled repair: tangled up in convoluted repair

The FEBS Journal, EarlyView.
In this review, we discuss recent findings derived from diverse genomic, biochemical and structural, imaging, and functional studies (B–E) that culminated in deep mechanistic insight (A) into the vital cellular process of transcription‐coupled nucleotide excision repair (TC‐NER).
Diana A. Llerena Schiffmacher, Yun Jin Pai, Alex Pines, Wim Vermeulen   +3 more
wiley   +1 more source

A Growing Pink Periorbital Papule in a Middle‐Aged Man: A Clinicopathological Challenge

International Journal of Dermatology, EarlyView.
ABSTRACT This report describes a case of a 48‐year‐old man who presented with a slowly enlarging lesion on the right lower eyelid that had been present for 8–9 years. The skin biopsy revealed an apocrine carcinoma of the eyelid. We discuss the clinical and histopathological differential diagnosis of apocrine carcinoma, along with treatment ...
Lydia A. Luu, Linglei Ma, Mark Russell
wiley   +1 more source