Formation and Conformation of Baicalin–Berberine and Wogonoside–Berberine Complexes
Formation and Conformation of Baicalin–Berberine and Wogonoside–Berberine ComplexesIt is well-known that baicalin–berberine complex (1) precipitates in the water decoction of numerous Chinese Medicinal formulae containing Radix Scutellariae and Rhizoma Coptidis or Cortex Phellodendri. In the current study, ionic interaction between the carboxylate ion of baicalin and the quaternary ammonium ion of berberine was revealed to be ...
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