Results 81 to 90 of about 1,388,848 (321)
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Tropical Solution of Discrete Best Approximation Problems
MathematicsWe consider discrete best approximation problems in the setting of tropical algebra, which is concerned with the theory and application of algebraic systems with idempotent operations. Given a set of input–output pairs of an unknown function defined on a
Nikolai Krivulin
doaj +1 more source
Best Approximation from the Kuhn-Tucker Set of Composite Monotone Inclusions [PDF]
, 2014 Kuhn-Tucker points play a fundamental role in the analysis and the numerical solution of monotone inclusion problems, providing in particular both primal and dual solutions.
Abdullah Alotaibi +3 more
core
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Best multipoint local L approximation
Journal of Approximation Theory, 1990 Let \(I=[a,b]\) be an interval and \(k\), \(n\) positive integers with \(k\leq n+1\).
Alzamel, A, Wolfe, J.M
openaire +2 more sources
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Weighted best local L approximation
Journal of Approximation Theory, 1984 For a weight w with some conditions near the origin the limit of the error \(\epsilon^{-n-1}\{f(\epsilon t)-P_{w,\epsilon}f(\epsilon t)\}\), where \(P_{w,\epsilon}f\) is the weighted best \(L^ p_{w,\epsilon}\) approximation of the function f in a class \(t^ p_{m,w}\), analogous to those considered by Calderón and Zygmund, is characterized. The limit is
Macías, R.A, Zó, F
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Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
On the best approximation in metric spaces
Journal of Numerical Analysis and Approximation Theory, 1975 Not available.
Costică Mustăţa
doaj +2 more sources