Results 51 to 60 of about 509,249 (300)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Best Order Sort [PDF]

Proceedings of the 2016 on Genetic and Evolutionary Computation Conference Companion, 2016
Finding the non-dominated sorting of a given set vectors has applications in Pareto based evolutionary multi-objective optimization (EMO), finding convex hull, linear optimization, nearest neighbor, skyline queries in database and many others. Among these, EMOs use this method for survival selection.
Proteek Chandan Roy, Md. Monirul Islam, Kalyanmoy Deb   +2 more
openaire   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

IgA-dominant postinfectious glomerulonephritis: a case report [PDF]

, 2023
IntroductionAcute postinfectious glomerulonephritis (APIGN) is an immunological glomerular disease that is an important health issue in developing countries.
Werner De Leon-Pérez, David Armas-Eguizabal, Rodolfo Moreno-Alvarado, Jonathan Chávez-Iñiguez, Guillermo Navarro-Blackaller   +4 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Parameter estimates of the best-supported growth model for dominant or co-dominant canopy beech (Fagus sylvatica) trees obtained by generalized least squares (GLS) regression.

, 2015
Parameter estimates of the best-supported growth model for dominant or co-dominant canopy beech (Fagus sylvatica) trees obtained by generalized least squares (GLS) regression.
David I. Forrester (710891), Knut Sturm (710892), Werner Härdtle (347099), Goddert von Oheimb (570339), Andreas Fichtner (672705)   +4 more
core   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Relationship between the relative abundance of dominant bacterial phyla and pH. A linear model fit was the best fit for the relative abundance of all phyla except (d) Tenericutes, whose best fit was a quadratic model.

, 2015
Relationship between the relative abundance of dominant bacterial phyla and pH. A linear model fit was the best fit for the relative abundance of all phyla except (d) Tenericutes, whose best fit was a quadratic model.
Priyanka Kumari (659676), Hong L. Choi (659677), Sartika I. A. Sudiarto (801894)   +2 more
core   +1 more source