Results 61 to 70 of about 512,259 (300)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

IgA-dominant postinfectious glomerulonephritis: a case report [PDF]

, 2023
IntroductionAcute postinfectious glomerulonephritis (APIGN) is an immunological glomerular disease that is an important health issue in developing countries.
Werner De Leon-Pérez, David Armas-Eguizabal, Rodolfo Moreno-Alvarado, Jonathan Chávez-Iñiguez, Guillermo Navarro-Blackaller   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Physical activity using wrist-worn accelerometers: comparison of dominant and non-dominant wrist [PDF]

, 2017
International audienceThe purpose of this study was to determine whether there is a difference in physical activity assessment between a wrist‐worn accelerometer at the dominant or non‐dominant arm.
Beghin, Laurent, Mikulovic, Jacques, Dieu, Olivier, Bui-Xuan, Gilles, Vanhelst, Jeremy, Fardy, Paul S   +5 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Optimizing payments in dominant-strategy mechanisms for multi-parameter domains [PDF]

, 2012
In AI research, mechanism design is typically used to allocate tasks and resources to agents holding private information about their values for possible allocations.
Dufton, Lachlan, Polukarov, Maria, Victor Naroditskiy, Maria Polukarov, Nicholas R. Jennings, Jennings, Nicholas R., Jennings, Nicholas R, Lachlan Dufton, Naroditskiy, Victor   +8 more
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Inference about soil variability from the structure of the best wavelet packer basis [PDF]

, 2007
The plausibility of the assumption that soil variation can be treated as a realization of a random spatial process that is stationary in the variance can break down in various ways. It is possible to test the assumption using methods based on the wavelet
Lark, R. M.
core   +1 more source

Fuzzy Subordination Results for Meromorphic Functions Connected with a Linear Operator

Fractal and Fractional
The concept of subordination is expanded in this study from the fuzzy sets theory to the geometry theory of analytic functions with a single complex variable.
Ekram E. Ali, Miguel Vivas-Cortez, Rabha M. El-Ashwah, Abeer M. Albalahi   +3 more
doaj   +1 more source