Results 171 to 180 of about 385,892 (273)

Unveiling Multi‐Scale Architectural Features in Single‐Cell Hi‐C Data Using scCAFE

Advanced Science, EarlyView.
scCAFE is a deep learning framework designed to identify multi‐scale 3D genome architectural features from single‐cell Hi‐C data without dense imputation. It predicts chromatin loops, TAD‐like domains, and A/B compartments, enabling efficient characterization of organization at the single‐cell level. scCAFE also identifies marker loop anchors, offering
Fuzhou Wang, Jiecong Lin, Hamid Alinejad‐Rokny, Wenjing Ma, Lingkuan Meng, Lei Huang, Jixiang Yu, Nanjun Chen, Yuchen Wang, Zhongyu Yao, Weidun Xie, Ka‐Chun Wong, Xiangtao Li   +12 more
wiley   +1 more source

Pertinence of contact duration as edge feature for epidemic spread analysis. [PDF]

Sci Rep
Shetty RD, Bhattacharjee S.
europepmc   +1 more source

Enhanced the Trans‐Cleavage Activity of CRISPR‐Cas12a Using Metal‐Organic Frameworks as Stimulants for Efficient Electrochemical Sensing of Circulating Tumor DNA

Advanced Science, EarlyView.
This work designs manganese metal‐organic frameworks (Mn‐MOFs) co‐assembled with Cas12a/crRNA, enabling rapid release of Mn2⁺ under mild conditions. The MOFs‐induced proximity effect sustains Mn2⁺‐Cas12a/crRNA interactions, enhancing the trans‐cleavage activity of complex available to develop an electrochemical biosensor based on Mn‐MOFs‐enhanced ...
Shuai Wu, Yincheng Liu, Tianyu Zeng, Tianci Zhou, Yanting Sun, Ying Deng, Juan Zhang, Genxi Li, Yongmei Yin   +8 more
wiley   +1 more source

Best proximity points for semi-cyclic contraction pairs in regular cone metric spaces

, 2017
M. Ahmadi Baseri, H. Mazaheri
openalex   +2 more sources

Evidence supporting a catalytic pentad mechanism for the proteasome and other N-terminal nucleophile enzymes. [PDF]

Nat Commun
Fung D, Razi A, Pandos M, Velez B, Fermin Perez E, Adams L, Rawson S, Walsh RM, Hanna J.   +8 more
europepmc   +1 more source

Enhanced Catalytic Cycle of Glucose Oxidation and Reactive Species with ROS and RHS Generation Mediated by Galvanic Engineering of Dual Atomic Sites on Covalent Organic Frameworks Demonstrating Synergistic Bimetal Tumor Treatment

Advanced Science, EarlyView.
A galvanic replacement is used to control dual atomic metals (Au and Ir) on a covalent organic framework (COF) nanoparticle and then coated with hyaluronic acid (HA). Under a specific bimetallic ratio (COF/Aux/Ir1‐x), the optimization can be achieved for the conversion of intracellular nutrients into reactive species (HOCl and O2• ─) and effectively ...
Wei‐Chung Pan, Cheng‐Hung Luo, Wen‐Ling Lin, Liu‐Chun Wang, Divinah Manoharan, Po‐Ya Chang, Hwo‐Shuenn Sheu, Chen‐Hao Yeh, Chia‐Jui Yen, Chen‐Sheng Yeh   +9 more
wiley   +1 more source

Graph-Based 3-Dimensional Spatial Gene Neighborhood Networks of Single Cells in Gels and Tissues. [PDF]

BME Front
Fang Z, Krusen K, Priest H, Wang M, Kim S, Sriram A, Yellanki A, Singh A, Horwitz E, Coskun AF.   +9 more
europepmc   +1 more source

The State of High‐Resolution Imaging of the Human Inner Ear: A Look Into the Black Box

Advanced Science, EarlyView.
High‐resolution imaging of the cochlea is challenged by numerous unique aspects of this organ, where sensorineural cells, crucial for hearing, are too small for conventional modalities like magnetic resonance imaging and computed tomography. This article reviews current imaging techniques, emerging technologies, and innovations aimed at improving ...
Shelley Batts, Nancy Pham, Guillermo Tearney, Konstantina M. Stankovic   +3 more
wiley   +1 more source

Machine Learning Prediction of Left Ventricular Assist Device Thrombosis from Acoustic Harmonic Power. [PDF]

Bioengineering (Basel)
Carlson KD, Dragomir-Daescu D, Boilson BA.   +2 more
europepmc   +1 more source

Particle‐Assisted Optoelectronic Tweezers for Manipulating Single Cells and Microparticles

Advanced Science, EarlyView.
This work introduces a particle‐assisted optoelectronic tweezers (OET) technique that uses Ag‐SiO2 microparticles as intermediaries to manipulate cells and microparticles via particle‐induced dielectrophoresis. The method extends the OET manipulation range while reducing cell damage.
Ao Wang, Shuzhang Liang, Caiding Ni, Yongyi Jia, Kangjie Wu, Wenyan Niu, Shunxiao Huang, Kaiyi Peng, Chutian Wang, Yingjian Guo, Zhijun Zhao, Lingze Zhang, Mingjie Liu, Lin Feng   +13 more
wiley   +1 more source