Results 141 to 150 of about 128,101 (191)

BET Bromodomain Inhibition Potentiates Ocular Melanoma Therapy by Inducing Cell Cycle Arrest. [PDF]

Invest Ophthalmol Vis Sci
Chen X, Huang R, Zhang Z, Song X, Shen J, Wu Q.   +5 more
europepmc   +1 more source

BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes.

Blood, 2022
Zaiken MC, Flynn R, Paz KG, Rhee SY, Jin S, Mohamed FA, Saha A, Thangavelu G, Park PMC, Hemming ML, Sage PT, Sharpe AH, DuPage M, Bluestone JA, Panoskaltsis-Mortari A, Cutler CS, Koreth J, Antin JH, Soiffer RJ, Ritz J, Luznik L, Maillard I, Hill GR, MacDonald KPA, Munn DH, Serody JS, Murphy WJ, Kean LS, Zhang Y, Bradner JE, Qi J, Blazar BR.   +31 more
europepmc   +1 more source

4-Methyl-1,2,3-Triazoles as N-Acetyl-Lysine Mimics Afford Potent BET Bromodomain Inhibitors with Improved Selectivity. [PDF]

J Med Chem, 2021
Cui H, Carlson AS, Schleiff MA, Divakaran A, Johnson JA, Buchholz CR, Zahid H, Vail NR, Shi K, Aihara H, Harki DA, Miller GP, Topczewski JJ, Pomerantz WCK.   +13 more
europepmc   +1 more source

MYC Family Amplification Dictates Sensitivity to BET Bromodomain Protein Inhibitor Mivebresib (ABBV075) in Small-Cell Lung Cancer. [PDF]

Mol Cancer Res
Plotnik JP, Zha Z, Feng W, Lee I, Riehm J, McClure RA, Sandoval S, Uziel T, Murphy E, Lu X, Lam LT.   +10 more
europepmc   +1 more source

BET bromodomain inhibitor JQ1 regulates spermatid development by changing chromatin conformation in mouse spermatogenesis. [PDF]

Genes Dis, 2022
Wang X, Sang M, Gong S, Chen Z, Zhao X, Wang G, Li Z, Huang Y, Chen S, Xie G, Duan E, Sun F.   +11 more
europepmc   +1 more source

Epigenetic modulation through BET bromodomain inhibitors as a novel therapeutic strategy for progranulin-deficient frontotemporal dementia. [PDF]

Sci Rep
Rosenthal ZC, Fass DM, Payne NC, She A, Patnaik D, Hennig KM, Tesla R, Werthmann GC, Guhl C, Reis SA, Wang X, Chen Y, Placzek M, Williams NS, Hooker J, Herz J, Mazitschek R, Haggarty SJ.   +17 more
europepmc   +1 more source

BET bromodomain protein inhibition reverses chimeric antigen receptor extinction and reinvigorates exhausted T cells in chronic lymphocytic leukemia. [PDF]

J Clin Invest, 2021
Kong W, Dimitri A, Wang W, Jung IY, Ott CJ, Fasolino M, Wang Y, Kulikovskaya I, Gupta M, Yoder T, DeNizio JE, Everett JK, Williams EF, Xu J, Scholler J, Reich TJ, Bhoj VG, Haines KM, Maus MV, Melenhorst JJ, Young RM, Jadlowsky JK, Marcucci KT, Bradner JE, Levine BL, Porter DL, Bushman FD, Kohli RM, June CH, Davis MM, Lacey SF, Vahedi G, Fraietta JA.   +32 more
europepmc   +1 more source

BET bromodomain proteins regulate transcriptional reprogramming in genetic dilated cardiomyopathy. [PDF]

JCI Insight, 2020
Antolic A, Wakimoto H, Jiao Z, Gorham JM, DePalma SR, Lemieux ME, Conner DA, Lee DY, Qi J, Seidman JG, Bradner JE, Brown JD, Haldar SM, Seidman CE, Burke MA.   +14 more
europepmc   +1 more source

BET bromodomain inhibition attenuates cardiac phenotype in myocyte-specific lamin A/C-deficient mice. [PDF]

J Clin Invest, 2020
Auguste G, Rouhi L, Matkovich SJ, Coarfa C, Robertson MJ, Czernuszewicz G, Gurha P, Marian AJ.   +7 more
europepmc   +1 more source

BET bromodomain inhibitors PFI-1 and CPI-203 suppress the development of follicular lymphoma via regulating Wnt/β-catenin signaling. [PDF]

Heliyon
Bai M, Huang Y, Suo X, Wang L, Han W, Zhang W.   +5 more
europepmc   +1 more source