Results 41 to 50 of about 767,969 (287)

BET inhibitors synergize with sunitinib in melanoma through GDF15 suppression

Experimental and Molecular Medicine, 2023
Cancer: a drug combination for combating melanoma Drugs that target proteins involved in issuing stop and start commands to cancer-related genes help to sensitize melanoma cells to a widely used anti-cancer therapy, leading to tumor shrinkage in mice ...
Furong Zeng, Yayun Li, Yu Meng, Huiyan Sun, Yi He, Mingzhu Yin, Xiang Chen, Guangtong Deng   +7 more
doaj   +1 more source

Stereoselective synthesis of allele-specific BET inhibitors

Organic & Biomolecular Chemistry, 2020
Developing stereoselective synthetic routes that are efficient and cost-effective allows easy access to allele-selective bumped BET inhibitors.
Adam G. Bond, Andrea Testa, Alessio Ciulli   +2 more
openaire   +4 more sources

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Altered regulation and expression of genes by BET family of proteins in COPD patients.

PLoS ONE, 2017
BackgroundBET proteins (BRD2, BRD3, BRDT and BRD4) belong to the family of bromodomain containing proteins, which form a class of transcriptional co-regulators.
Rajneesh Malhotra, Nisha Kurian, Xiao-Hong Zhou, Fanyi Jiang, Susan Monkley, Amy DeMicco, Ib G Clausen, Göran Dellgren, Goran Edenro, Miika J Ahdesmäki, Maryam Clausen, Lisa Öberg, Elisabeth Israelsson, Graham Belfield, Outi Vaarala   +14 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Bromodomain Inhibition Attenuates the Progression and Sensitizes the Chemosensitivity of Osteosarcoma by Repressing GP130/STAT3 Signaling

Frontiers in Oncology, 2021
Osteosarcoma is the most common primary malignant bone tumor, and there are few ideal clinically available drugs. The bromodomain and extraterminal domain (BET) protein is an emerging target for aggressive cancer, but therapies targeting the BET in ...
Yafei Jiang, Yafei Jiang, Gangyang Wang, Gangyang Wang, Haoran Mu, Haoran Mu, Xiaojun Ma, Xiaojun Ma, Zhuoying Wang, Zhuoying Wang, Yu Lv, Tao Zhang, Tao Zhang, Jing Xu, Jing Xu, Jinzeng Wang, Yunqi Li, Jing Han, Jing Han, Mengkai Yang, Mengkai Yang, Zongyi Wang, Zongyi Wang, Ke Zeng, Ke Zeng, Xinmeng Jin, Xinmeng Jin, Song Xue, Song Xue, Mingzhu Yin, Wei Sun, Wei Sun, Yingqi Hua, Yingqi Hua, Zhengdong Cai, Zhengdong Cai   +35 more
doaj   +1 more source

Impact of structurally diverse BET inhibitors on SIRT1

Gene, 2020
The epigenetic regulation of gene expression is controlled by various processes, of which one is histone acetylation. Many proteins control gene expression via histone acetylation. Those proteins include sirtuins (SIRTs) and bromodomain and extraterminal proteins (BETs), which are known to regulate same cellular processes and pathways.
Jonna Tenhunen, Tarja Kokkola, Marjo Huovinen, Minna Rahnasto-Rilla, Maija Lahtela-Kakkonen   +4 more
openaire   +4 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source