Targeting bromodomain-containing proteins: research advances of drug discovery [PDF]
Molecular Biomedicine, 2023 Bromodomain (BD) is an evolutionarily conserved protein module found in 46 different BD-containing proteins (BCPs). BD acts as a specific reader for acetylated lysine residues (KAc) and serves an essential role in transcriptional regulation, chromatin ...
Zhaoping Pan, Gu He, Zhao Yuxi
exaly +6 more sources
Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins. [PDF]
J Neurodev Disord, 2013 Neurodevelopmental disorders are classified as diseases that cause abnormal functions of the brain or central nervous system. Children with neurodevelopmental disorders show impaired language and speech abilities, learning and memory damage, and poor ...
Li J, Zhao G, Gao X.
europepmc +7 more sources
Functional networks of the human bromodomain-containing proteins. [PDF]
Front Bioinform, 2022 Background: Bromodomains are a structurally conserved epigenetic reader domain that bind to acetylated lysine residues in both histone and non-histone proteins.
Gao C, Glass KC, Frietze S.
europepmc +5 more sources
Identification of bromodomain-containing proteins prognostic value and expression significance based on a genomic landscape analysis of ovarian serous cystadenocarcinoma [PDF]
Frontiers in Oncology, 2022 BackgroundOvarian serous cystadenocarcinoma (OSC), a common gynecologic tumor, is characterized by high mortality worldwide. Bromodomain (BRD)-containing proteins are a series of evolutionarily conserved proteins that bind to acetylated Lys residues of ...
Zhang J +6 more
exaly +4 more sources
Biological function and histone recognition of family IV bromodomain‐containing proteins [PDF]
Journal of Cellular Physiology, 2018 Bromodomain proteins function as epigenetic readers that recognize acetylated histone tails to facilitate the transcription of target genes. There are approximately 60 known human bromodomains, which are divided into eight sub‐families based on structural conservation. The bromodomain‐containing proteins in family IV include seven members (BRPF1, BRPF2,
Karen C Glass
exaly +5 more sources
The Aggregation of ATAD2 Bromodomain in Solution
Chinese Journal of Magnetic Resonance, 2023 ATPase family AAA domain-containing protein 2 (ATAD2) is a chromatin regulator, also known as an oncogenic transcription cofactor. Its abnormal expression is closely related to the occurrence and development of various malignant tumors. ATAD2 consists of
WANG Yuanfang +5 more
doaj +2 more sources
Recent Progress and Prospect in Studying Selective Inhibitors Toward Bromodomain Family Members [PDF]
MoleculesBromodomain (BRD)-containing proteins are gaining attention as key targets in epigenetic drug development. BRDs bind to acetylated lysine residues on histones and other proteins, significantly impacting transcriptional regulation and chromatin remodeling.
Chen J, Huang Y, Wang J, Yang W.
europepmc +2 more sources
Bromodomain-containing protein 4 in inflammatory diseases: molecular mechanisms and therapeutic potential. [PDF]
J Inflamm (Lond)Bromodomain-containing protein 4 (BRD4), a key member of the bromodomain and extra-terminal (BET) family, plays a critical role in regulating gene expression as an epigenetic reader.
Frascatani R +3 more
europepmc +2 more sources
Sevoflurane attenuates myocardial ischemia/reperfusion injury by up-regulating microRNA-99a and down-regulating BRD4 [PDF]
Acta Cirúrgica Brasileira, 2023 Purpose: It has been explored that sevoflurane (Sevo) is cardioprotective in myocardial ischemia/reperfusion injury (MI/RI) and mediates microRNA (miRNA) expression that control various physiological systems.
Xiaomin Bie, Jiying Ao, Degang Zhu
doaj +1 more source
mSystems, 2019 To better understand the transcriptomic interplay of organisms associated with lymphatic filariasis, we conducted multispecies transcriptome sequencing (RNA-Seq) on the filarial nematode Brugia malayi, its Wolbachia endosymbiont wBm, and its laboratory ...
Matthew Chung +11 more
doaj +3 more sources