Targeting bromodomain-containing proteins: research advances of drug discovery [PDF]
Molecular Biomedicine, 2023 Bromodomain (BD) is an evolutionarily conserved protein module found in 46 different BD-containing proteins (BCPs). BD acts as a specific reader for acetylated lysine residues (KAc) and serves an essential role in transcriptional regulation, chromatin ...
Zhaoping Pan +10 more
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Functional networks of the human bromodomain-containing proteins [PDF]
Frontiers in Bioinformatics, 2022 Background: Bromodomains are a structurally conserved epigenetic reader domain that bind to acetylated lysine residues in both histone and non-histone proteins.
Cong Gao +4 more
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Biological function and histone recognition of family IV bromodomain-containing proteins. [PDF]
J Cell Physiol, 2018 Bromodomain proteins function as epigenetic readers that recognize acetylated histone tails to facilitate the transcription of target genes. There are approximately 60 known human bromodomains, which are divided into eight sub‐families based on structural conservation. The bromodomain‐containing proteins in family IV include seven members (BRPF1, BRPF2,
Lloyd JT, Glass KC.
europepmc +5 more sources
Development of neurodevelopmental disorders: a regulatory mechanism involving bromodomain-containing proteins [PDF]
Journal of Neurodevelopmental Disorders, 2013 Neurodevelopmental disorders are classified as diseases that cause abnormal functions of the brain or central nervous system. Children with neurodevelopmental disorders show impaired language and speech abilities, learning and memory damage, and poor ...
Li Junlin, Zhao Guifang, Gao Xiaocai
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Pharmacological inhibition of bromodomain-containing proteins in inflammation. [PDF]
Cold Spring Harb Perspect Biol, 2014 Inflammation is associated with the activation of genes that contribute to immune defense and tissue repair. The bromodomain-containing proteins of the BET family, which recognize histone lysine acetylation, play a key role in the transcriptional control of inflammatory genes. Inhibition of BET proteins by the small-molecule inhibitor I-BET affects the
Schaefer U.
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Identification of bromodomain-containing proteins prognostic value and expression significance based on a genomic landscape analysis of ovarian serous cystadenocarcinoma [PDF]
Frontiers in Oncology, 2022 BackgroundOvarian serous cystadenocarcinoma (OSC), a common gynecologic tumor, is characterized by high mortality worldwide. Bromodomain (BRD)-containing proteins are a series of evolutionarily conserved proteins that bind to acetylated Lys residues of ...
Juan Zhang +6 more
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Bromodomain-containing proteins in prostate cancer [PDF]
Molecular and Cellular Endocrinology, 2018 Several oncogenic factors have been involved in prostate cancer progression. However, therapeutic approaches still focus on suppression of androgen receptor (AR) signaling. In fact, whereas the full-length AR incorporates a ligand-binding domain, which has become a drug target for competitive inhibitors, other transcription factors often do not have ...
Ian G Mills, Alfonso Urbanucci
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Alternative Mechanisms for DNA Engagement by BET Bromodomain-Containing Proteins. [PDF]
Biochemistry, 2022 Epigenetic reader domains regulate chromatin structure and modulate gene expression through the recognition of post-translational modifications on histones. Recently, reader domains have also been found to harbor double-stranded (ds) DNA-binding activity, which is as functionally critical as histone association.
Kalra P +4 more
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Targeting bromodomain and extraterminal proteins in cardiovascular disease: Pathological mechanisms and therapeutic applications [PDF]
Journal of International Medical ResearchBromodomain and extraterminal proteins have emerged as key epigenetic regulators that coordinate transcriptional programs fundamental to cardiovascular physiology and disease.
Kaixuan Zhang, Yangkai Fan, Yuan Wang
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USP24 stabilizes bromodomain containing proteins to promote lung cancer malignancy. [PDF]
Sci Rep, 2020 AbstractBromodomain (BRD)-containing proteins are important for chromatin remodeling to regulate gene expression. In this study, we found that the deubiquitinase USP24 interacted with BRD through its C-terminus increased the levels of most BRD-containing proteins through increasing their protein stability by the removal of ubiquitin from Lys391/Lys400 ...
Wang SA +4 more
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