Results 1 to 10 of about 5,434 (195)

JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states

Epigenetics, 2018
The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET ...
Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon   +2 more
exaly   +3 more sources

The Disordered Region of ASXL1 Acts as an Auto‐Regulator Through Condensation [PDF]

Advanced Science
Intrinsically disordered regions (IDRs) are common in chromatin regulators, yet how their sequence encodes regulatory logic remains unclear. Here, we show that the long linker IDR of ASXL1 (Additional Sex Combs Like 1) functions as an embedded ...
Xiao Fang, Qiwei Li, Wenqing Zhang
doaj   +3 more sources

Interaction of coronavirus E protein with BRD2 plays important regulatory roles in viral replication and induction of pro-inflammatory response [PDF]

Journal of Virology
The devastating COVID-19 pandemic has urged continuous efforts to uncover innovative intervention measures through a thorough understanding of viral and associated host protein functions.
Shumin Li, Ding Xiang Liu
doaj   +2 more sources

BRD2 induces drug resistance through activation of the RasGRP1/Ras/ERK signaling pathway in adult T‐cell lymphoblastic lymphoma

Cancer Communications, 2020
Background Adult patients with T‐cell lymphoblastic lymphoma (T‐LBL) are treated with high‐intensity chemotherapy regimens, but the response rate is still unsatisfactory because of frequent drug resistance.
Xiao-Peng Tian, Hui-Qiang Huang, Hui-Lan Rao   +2 more
exaly   +2 more sources

BRD2 phase separation activates super-enhancer-driven ATG7 transcription to promote ferritinophagy in depression [PDF]

Scientific Reports
Depression is a psychiatric disorder which affects many aspects of the social life of patients; however, the molecular biological mechanisms underlying its development are not fully understood.
Zhen Li, Xiaoling Wang, Qinglian Li, Yangping Liu, Wenwen Si, Dongfeng Chen, Qizhang Wang, Meiling Zhu   +7 more
doaj   +2 more sources

Dissecting the Role of BET Bromodomain Proteins BRD2 and BRD4 in Human NK Cell Function

Frontiers in Immunology, 2021
Natural killer (NK) cells are innate lymphocytes that play a pivotal role in the immune surveillance and elimination of transformed or virally infected cells.
Adam P Cribbs, Panagis Filippakopoulos, Martin Philpott   +2 more
exaly   +3 more sources

Bromodomain‐containing protein 2 gene polymorphism among patients with photosensitive epilepsy in Indonesia [PDF]

Epilepsia Open
Objectives Genetic‐associated epilepsy in the Indonesian population is rarely discussed, and no study was specifically studied about photosensitive epilepsy.
Diah Kurnia Mirawati, Muhana Fawwazy Ilyas, Muhammad Hafizhan, Stefanus Erdana Putra, Suroto Suroto, Subandi Subandi, Rivan Danuaji, Pepi Budianto, Yetty Hambarsari, Baarid Luqman Hamidi, Hanindia Riani Prabaningtyas, Ervina Arta Jayanti Hutabarat, Ira Ristinawati, Teddy Tejomukti, Raden Andi Ario Tedjo, Faris Khairuddin Syah   +15 more
doaj   +2 more sources

Histone demethylase KDM9 activates the CCND1/AKT pathway to promote the malignant progression of gliomas through interaction with BRD2 [PDF]

Cellular and Molecular Life Sciences
Gliomas are highly aggressive brain tumors with limited treatment options, thus, it is necessary to identify new molecular targets for therapeutic intervention. Epigenetic aberration plays a vital role in the malignant progression of tumors.
Jin Cheng, Xingzhi Peng, Siyuan Tang, Peijun Zhou, Zhuan Zhou, Zenghui Mao, Dan Li, Lifang Yang, Jinwu Peng   +8 more
doaj   +2 more sources

Epigenetic Reader Bromodomain Containing Protein 2 Facilitates Pathological Cardiac Hypertrophy via Regulating the Expression of Citrate Cycle Genes

Frontiers in Pharmacology, 2022
The bromodomain and extra-terminal domain proteins (BETs) family serve as epigenetic “readers”, which recognize the acetylated histones and recruit transcriptional regulator complexes to chromatin, eventually regulating gene transcription.
Zhirong Lin, Zhenzhen Li, Zhen Guo, Yanjun Cao, Jingyan Li, Peiqing Liu, Zhuoming Li   +6 more
doaj   +1 more source

Systematic analysis of the BET family in adrenocortical carcinoma: The expression, prognosis, gene regulation network, and regulation targets

Frontiers in Endocrinology, 2023
BackgroundBromodomain and extracellular terminal (BET) family (including BRD2, BRD3, and BRD4) is considered to be a major driver of cancer cell growth and a new target for cancer therapy.
Yongli Situ, Quanyan Liang, Ziying Zeng, Jv Chen, Zheng Shao, Qinying Xu, Xiaoyong Lu, Yongshi Cui, Juying Zhang, Lingling Lu, Li Deng   +10 more
doaj   +1 more source