Results 11 to 20 of about 5,434 (195)
Brd2 haploinsufficiency extends lifespan and healthspan in C57B6/J mice.
PLoS ONE, 2020 Aging in mammals is the gradual decline of an organism's physical, mental, and physiological capacity. Aging leads to increased risk for disease and eventually to death.
Shilpa Pathak +4 more
doaj +4 more sources
H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs
Cell Reports, 2016 Summary: Histone variant H2A.Z occupies the promoters of active and poised, bivalent genes in embryonic stem cells (ESCs) to regulate developmental programs, yet how it contributes to these contrasting states is poorly understood.
Lauren E. Surface +8 more
doaj +7 more sources
PLoS Genetics, 2012 H2A.Z is an essential histone variant that has been implicated to have multiple chromosomal functions. To understand how H2A.Z participates in such diverse activities, we sought to identify downstream effector proteins that are recruited to chromatin via
Ryan Draker +5 more
doaj +5 more sources
BRD2 regulation of sigma-2 receptor upon cholesterol deprivation [PDF]
Life Science Alliance, 2021 Upon cholesterol deprivation, epigenetic bookmark reader BRD2 and master transcription factor SREBP2 form a complex at bookmarked chromatin (H3K27ac), thereby activating the transcription of the sigma-2 receptor—a recently unveiled player in cholesterol ...
Hongtao Shen +8 more
doaj +3 more sources
Brd2 inhibits adipogenesis via the ERK1/2 signaling pathway in 3T3-L1 adipocytes.
PLoS ONE, 2013 Bromodomain-containing protein 2 (Brd2) is a nuclear serine/threonine kinase involved in transcriptional regulation. In 3T3-L1 adipocytes, Brd2 normally co-represses PPARγ (peroxisome proliferator-activated receptor gamma) and inhibits adipogenesis. Here,
Kun Zang +9 more
doaj +2 more sources
Brd2/4 and Myc regulate alternative cell lineage programmes during early osteoclast differentiation in vitro [PDF]
iScience, 2021 Summary: Osteoclast (OC) development in response to nuclear factor kappa-Β ligand (RANKL) is critical for bone homeostasis in health and in disease. The early and direct chromatin regulatory changes imparted by the BET chromatin readers Brd2-4 and OC ...
Valentina S. Caputo +10 more
doaj +4 more sources
Association of BRD2 polymorphisms with photoparoxysmal response
Neuroscience Letters, 2006 A trait locus for electroencephalographic photoparoxysmal response (PPR) has been mapped to the chromosomal region 6p21 near a susceptibility locus for juvenile myoclonic epilepsy (JME). Linkage disequilibrium mapping revealed strong associations between JME and polymorphisms of the gene encoding the bromodomain-containing protein 2 (BRD2). The present
Susanne, Lorenz +8 more
openaire +3 more sources
PLoS ONE, 2011 Idiopathic generalized epilepsy (IGE) syndromes represent about 30% of all epilepsies. They have strong, but elusive, genetic components and sex-specific seizure expression.
Libor Velíšek +7 more
doaj +2 more sources
Mechanical strain-mediated reduction in RANKL expression is associated with RUNX2 and BRD2 [PDF]
Gene, 2020 Mechanical loading-related strains trigger bone formation by osteoblasts while suppressing resorption by osteoclasts, uncoupling the processes of formation and resorption. Osteocytes may orchestrate this process in part by secreting sclerostin (SOST), which inhibits osteoblasts, and expressing receptor activator of nuclear factor-κB ligand (RANKL ...
Galea, Gabriel L. +9 more
openaire +6 more sources
BRD2 (RING3) Is a Probable Major Susceptibility Gene for Common Juvenile Myoclonic Epilepsy [PDF]
The American Journal of Human Genetics, 2003 Juvenile myoclonic epilepsy (JME) is a common form of generalized epilepsy that starts in adolescence. A major JME susceptibility locus (EJM1) was mapped to chromosomal region 6p21 in three independent linkage studies, and association was reported between JME and a microsatellite marker in the 6p21 region.
Pal, Deb K +5 more
openaire +4 more sources