Genes and Diseases, 2022 As a BET bromodomain inhibitor, JQ1 has been proven have efficacy against a number of different cancers. In terms of male reproduction, JQ1 may be used as a new type of contraceptive, since JQ1 treatment in male mice could lead to germ cell defects and a
Gangcai Xie, Zhiran Li
exaly +4 more sources
Cancer Medicine, 2019 Aim JQ1, a BET bromodomain inhibitor, is a promising therapeutic approach for bladder cancer (BC). Our study aimed to determine whether autophagy is induced by JQ1 and its potential role toward proliferation in BC.
Tie Chong, Jianbin Ma
exaly +3 more sources
In Situ Bioorthogonal Synthesis of PROTACs via Dual-Responsive Cleavage for Synergistic Photo-Immunotherapy. [PDF]
Adv Sci (Weinh)A bioactive self‐delivering SNAP‐TAC platform responds to tumor‐associated cathepsin B and glutathione, enabling in situ bioorthogonal synthesis of a BRD4‐degrading proteolysis‐targeting chimera within the tumor microenvironment. The resulting BRD4 degradation and PD‐L1 downregulation synergize with photodynamic therapy‐induced immunogenic cell death ...
Jian S +14 more
europepmc +2 more sources
Glucose and Glutamine Deprivation Promotes Breast Cancer Lung Metastasis via BRD4-Dependent Enhancer Activation. [PDF]
Adv Sci (Weinh)To model a nutrient‐restricted tumor microenvironment, breast cancer cells were adapted to low glucose and glutamine levels. In the adapted cells, BRD4‐driven enhancer activation increases pro‐invasive EDN1 expression, facilitated by ATF3/c‐JUN and reinforced by enhancer RNA.
Bhattarai PY +4 more
europepmc +2 more sources
A Pancreatitis-Inspired Trypsinogen Nanoplatform Reprograms Tumor-Associated Macrophages via NF-κB for Pancreatic Cancer Immunotherapy. [PDF]
Adv Sci (Weinh)Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Cao L +7 more
europepmc +2 more sources
Synergistic inhibition of pancreatic cancer with anti-PD-L1 and c-Myc inhibitor JQ1
OncoImmunology, 2019 Human pancreatic ductal adenocarcinoma (PDAC) exhibits marginal responses to anti-PD-1/PD-L1 immunotherapy and its mechanism remains poorly understood. We have investigated the effect of anti-PD-L1 and c-Myc inhibition in PDAC.
Qing-Lin Fei, Yu Pan, Minggui Pan
exaly +2 more sources
Preclinical evaluation of JQ1 in esophageal squamous cell carcinoma: growth and migration suppression with BRD4-associated DNA damage and apoptotic signaling [PDF]
Frontiers in PharmacologyBackgroundEsophageal squamous cell carcinoma (ESCC) is an aggressive malignancy with limited therapeutic options. Bromodomain-containing protein 4 (BRD4), a BET family epigenetic reader, regulates oncogenic transcription and may represent a ...
Chunlan Pu +5 more
doaj +2 more sources
Pleiotropic effects of BET inhibition broadly boost tumor immunogenicity to CD8+ T cells [PDF]
OncoImmunologyBET inhibitors (BETi) have shown potential to augment tumor immunogenicity in melanoma. However, conflicting evidence exists regarding their precise mechanism of action, and their overall impact on melanoma immunogenicity and antitumoral T cell responses
Jeroen Melief +12 more
doaj +2 more sources
A photothermal immune hydrogel dressing for enhanced post-melanoma resection treatment [PDF]
Journal of NanobiotechnologyPostoperative complications such as tumor recurrence, wound infections, and delayed tissue regeneration persist as critical challenges in melanoma management.
Dehong Tan +10 more
doaj +2 more sources
Identification of a Novel Small Molecule Facilitating HIV Elimination by the "Shock-And-Kill" Approach. [PDF]
J Med VirolABSTRACT Antiretroviral therapy (ART) has markedly improved the prognosis of people living with HIV (PLWH); however, latent viral reservoirs remain a major barrier to a cure. The “Shock and Kill” strategy aims to reactivate latent provirus with latency‐reversing agents (LRAs) and subsequently eliminate the infected cells, yet most LRAs characterized to
Hara Y +7 more
europepmc +2 more sources