Results 21 to 30 of about 13,555 (204)

(+)-JQ1 Upregulates SIRT3 to Suppress cGAS/STING Pathway-Mediated Neuronal Inflammation and Ferroptosis After Hypoxic-Ischemic Encephalopathy [PDF]

Drug Design, Development and Therapy
Qianqian Yu,1,2,* Jiahao Ou,1,2,* Yuqi Luo,1,2,* Ming Shen,1,2 Jia Lou,3 Saizhi Jiang,4,5 Lizi Lin,5 Shutian Zhang,5 Jianghu Zhu,1,2 Zhenlang Lin,1,2 Mingchu Fang1,2 1Department of Neonatology, The Second Affiliated Hospital and ...
Yu Q, Ou J, Luo Y, Shen M, Lou J, Jiang S, Lin L, Zhang S, Zhu J, Lin Z, Fang M   +10 more
doaj   +2 more sources

BET bromodomain inhibitor JQ1 modulates microRNA expression in thyroid cancer cells

Oncology Reports, 2017
Anaplastic thyroid carcinoma (ATC) represents the most lethal thyroid cancer sub-type, currently unresponsive to standard treatments. Recently, bromodomain and extra-terminal (BET) proteins have emerged as attractive therapeutic targets in several diseases, including cancer.
Mio, Catia, Conzatti, Ketty, Baldan, Federica, Allegri, Lorenzo, Sponziello, Marialuisa, Rosignolo, Francesca, Russo, Diego, Filetti, Sebastiano, Damante, Giuseppe   +8 more
openaire   +6 more sources

Arsenic sulfide combined with JQ1, chemotherapy agents, or celecoxib inhibit gastric and colon cancer cell growth

Drug Design, Development and Therapy, 2015
Lian Zhang,1 Yingying Tong,1 Xiuli Zhang,1 Minggui Pan,2,3 Siyu Chen1 1Department of Oncology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Oncology and ...
Zhang L, Tong Y, Zhang X, Pan M, Chen S
doaj   +1 more source

Synthesis and biological profiling of (+)-JQ1 amides as BET inhibitors

, 2021
BET proteini su epigenetski biološki targeti koji regulišu ekspresiju gena i uključeni su u patogenezu kancera. Jedan od inhibitora ovih proteina koji je opisan u literaturi je derivat tienotriazolodiazepina (+)-JQ1.
Koravović, Mladen, Keramatnia, Fatemeh, Fischer, Marcus, Tasić, Gordana, Ranković, Zoran, Mayasundari, Anand, Savić, Vladimir   +6 more
core   +5 more sources

Selective BH3 mimetics synergize with BET inhibition to induce mitochondrial apoptosis in rhabdomyosarcoma cells

Neoplasia: An International Journal for Oncology Research, 2022
BH3 mimetics are promising novel anticancer therapeutics. By selectively inhibiting BCL-2, BCL-xL, or MCL-1 (i.e. ABT-199, A-1331852, S63845) they shift the balance of pro- and anti-apoptotic proteins in favor of apoptosis.
Ufuk Erdogdu, Nadezda Dolgikh, Stephanie Laszig, Vinzenz Särchen, Michael T. Meister, Marek Wanior, Stefan Knapp, Cathinka Boedicker   +7 more
doaj   +1 more source

The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells

Frontiers in Oncology, 2022
We reported previously that the BET inhibitor (BETi) JQ1 decreases levels of the DNA repair protein RAD51 and that this decrease is concomitant with increased levels of DNA damage.
Patrick L. Garcia, Aubrey L. Miller, Ling Zeng, Ling Zeng, Robert C. A. M. van Waardenburg, Eddy S. Yang, Eddy S. Yang, Eddy S. Yang, Karina J. Yoon   +8 more
doaj   +1 more source

BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction [PDF]

Journal of Dental Research, 2014
BET proteins are a group of epigenetic regulators controlling transcription through reading acetylated histone tails and recruiting transcription complexes. They are considered as potential therapeutic targets in many distinct diseases. A novel synthetic bromodomain and extraterminal domain (BET) inhibitor, JQ1, was proved to suppress oncogene ...
S, Meng, L, Zhang, Y, Tang, Q, Tu, L, Zheng, L, Yu, D, Murray, J, Cheng, S H, Kim, X, Zhou, J, Chen   +10 more
openaire   +2 more sources

The BET inhibitor attenuates the inflammatory response and cell migration in human microglial HMC3 cell line

Scientific Reports, 2021
Microglia, resident macrophages of the brain that act as primary immune cells, play essential roles in innate immunity and neuroinflammatory pathologies.
Mina Baek, Eunyoung Yoo, Hae In Choi, Ga Yeong An, Jin Choul Chai, Young Seek Lee, Kyoung Hwa Jung, Young Gyu Chai   +7 more
doaj   +1 more source

Resistance to BET inhibitors in lung adenocarcinoma is mediated by casein kinase phosphorylation of BRD4

Oncogenesis, 2021
Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic intervention.
Jack Calder, Amy Nagelberg, Jennifer Luu, Daniel Lu, William W. Lockwood   +4 more
doaj   +1 more source

Temporal Analysis of Brd4 Displacement in the Control of B Cell Survival, Proliferation, and Differentiation

Cell Reports, 2020
Summary: JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces cell
Isabella Y. Kong, Joel S. Rimes, Amanda Light, Izabela Todorovski, Sarah Jones, Eric Morand, Deborah A. Knight, Ylva E. Bergman, Simon J. Hogg, Hendrik Falk, Brendon J. Monahan, Paul A. Stupple, Ian P. Street, Susanne Heinzel, Philippe Bouillet, Ricky W. Johnstone, Philip D. Hodgkin, Stephin J. Vervoort, Edwin D. Hawkins   +18 more
doaj   +1 more source