Results 31 to 40 of about 13,555 (204)
, 2023 The top 10 common genes upregulated or downregulated from 009P1-, 009P2-, (+)-JQ1- and SAHA-treated BCBL-1 cells.
Tran Phuc (3948350) +10 more
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General mechanism of JQ1 in inhibiting various types of cancer
Molecular Medicine Reports, 2020 Bromodomain‑containing 4 (BRD4) is a histone modification reader and transcriptional regulator that has been reported to interact with acetylated lysine histone motifs transcription factors (TFs), transcription co‑activators and RNA polymerase II. The selective small molecule inhibitor JQ1, which binds competitively to bromodomains, has been reported ...
Jiang, Guojuan +3 more
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Cell Death and Disease, 2021 Bromodomain-containing protein 4 (BRD4) has emerged as a promising treatment target for bone-related disorders. (+)-JQ1, a thienotriazolodiazepine compound, has been shown to inhibit pro-osteoclastic activity in a BRD4-dependent approach and impede bone ...
Ying Liu +8 more
doaj +1 more source
JQ1 is a potential therapeutic option for COPD patients with agrin overexpression [PDF]
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2018 Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and death worldwide. It is characterized by chronic pulmonary inflammation and obstructed airflow from the lungs. To date, there is no effective treatment for COPD. The activation of the agrin (AGRN-YAP pathway can promote heart regeneration. Because agrin can induce
Zhen, Xiao +3 more
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Metformin and JQ1 synergistically inhibit obesity-activated thyroid cancer [PDF]
Endocrine-Related Cancer, 2018 Compelling epidemiological evidence shows a strong positive correlation of obesity with thyroid cancer. In vivo studies have provided molecular evidence that high-fat-diet-induced obesity promotes thyroid cancer progression by aberrantly activating leptin-JAK2-STAT3 signaling in a mouse model
Sunmi, Park +3 more
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BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries
EBioMedicine, 2015 Background: Intimal hyperplasia is a common cause of many vasculopathies. There has been a recent surge of interest in the bromo and extra-terminal (BET) epigenetic “readers” including BRD4 since the serendipitous discovery of JQ1(+), an inhibitor ...
Bowen Wang +6 more
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Co-Encapsulation of Paclitaxel and JQ1 in Zein Nanoparticles as Potential Innovative Nanomedicine
Micromachines, 2022 The manuscript describes the development of zein nanoparticles containing paclitaxel (PTX) and the bromo-and extra-terminal domain inhibitor (S)-tertbutyl2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno(3,2-f)(1,2,4)triazolo(4,3-a)(1,4)diazepin-6-yl)acetate (JQ1) together with their cytotoxicity on triple-negative breast cancer cells.
Marilena Celano +7 more
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Epigenetics, 2018 The bromodomain and extra-terminal domain (BET) proteins are promising drug targets for cancer and immune diseases. However, BET inhibition effects have been studied more in the context of bromodomain-containing protein 4 (BRD4) than BRD2, and the BET ...
Lusy Handoko +13 more
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The BRD4 inhibitor JQ1 suppresses tumor growth by reducing c-Myc expression in endometrial cancer
Journal of Translational Medicine, 2022 Background Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported for the treatment of various human cancers, but its potential impact on EC remains
Yingxin Pang +9 more
doaj +1 more source
BRD4 promotes heterotopic ossification through upregulation of LncRNA MANCR
Bone & Joint Research, 2021 Aims: Acquired heterotopic ossification (HO) is a debilitating disease characterized by abnormal extraskeletal bone formation within soft-tissues after injury. The exact pathogenesis of HO remains unknown.
Lei Liu +9 more
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