Results 41 to 50 of about 5,434 (195)

Expression of GABAergic markers in the Brd2+/− mice and Brd2+/+ littermate controls.

, 2013
(A) Simplified scheme of a direct basal ganglia pathway, which includes primary motor cortex, caudate-putamen (CPu) and globus pallidus (GP), substantia nigra reticulata (SNR), and its outputs the superior colicullus (SC) and ventral medial thalamic ...
Jana Velíšková (5423975), Stephania Macchiarulo (345520), David A. Greenberg (319010), Giorgi Maglakelidze (345522), Debra J. Wolgemuth (124823), Enyuan Shang (345517), Tamar Chachua (345519), Libor Velíšek (345515)   +7 more
core   +1 more source

The double bromodomain protein Brd2 promotes B cell expansion and mitogenesis [PDF]

Journal of Leukocyte Biology, 2013
ABSTRACTBromodomain-containing transcriptional regulators represent new epigenetic targets in different hematologic malignancies. However, bromodomain-mediated mechanisms that couple histone acetylation to transcription in lymphopoiesis and govern mature lymphocyte mitogenesis are poorly understood.
Anna C, Belkina, Wanda P, Blanton, Barbara S, Nikolajczyk, Gerald V, Denis   +3 more
openaire   +2 more sources

Pleiotrophin antagonizes Brd2 during neuronal differentiation

, 2015
Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell-cycle-associated genes and therefore involved in cell cycle progression.
García-Gutiérrez, Pablo, García-Domínguez, Mario, Juárez-Vicente, Francisco, Wolgemuth, Debra J.   +3 more
core   +1 more source

The Double Bromodomain Proteins Brd2 and Brd3 Couple Histone Acetylation to Transcription [PDF]

Molecular Cell, 2008
Posttranslational histone modifications are crucial for the modulation of chromatin structure and regulation of transcription. Bromodomains present in many chromatin-associated proteins recognize acetylated lysines in the unstructured N-terminal regions of histones.
LeRoy, Gary, Rickards, Brenden, Flint, S.J.   +2 more
openaire   +2 more sources

Allergen fragrance molecules: a potential relief for COVID-19

BMC Complementary Medicine and Therapies, 2021
Background The latest coronavirus SARS-CoV-2, discovered in China and rapidly spread Worldwide. COVID-19 affected millions of people and killed hundreds of thousands worldwide.
Aslı Deniz Aydın, Faruk Altınel, Hüseyin Erdoğmuş, Çağdaş Devrim Son   +3 more
doaj   +1 more source

Bromodomain and Extra-Terminal (BET) Domain Protein Inhibitors for Solid Tumor Cancers [PDF]

Journal of Immunotherapy and Precision Oncology, 2020
The bromodomain and extraterminal (BET) domain protein family is involved in the process of transcription of genetic information. The BET protein family includes BRD2, BRD3, BRD4, and bromodomain testis-specific protein.
Martin V. Nguyen, Lydia Loof, Gerald S. Falchook   +2 more
doaj   +1 more source

BRD4-BRD2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification [PDF]

, 2017
Pluripotent Stem Cells (PSCs) hold great clinical potential, as they possess the capacity to differentiate into fully specialised tissues such as pancreas, liver, neurons and cardiac muscle.
Michael Zengerle, Findlay, Greg M., Rosalia Fernandez‐Alonso, Fernandez-Alonso, Rosalia, Lindsay Davidson, Hukelmann, Jens, Angus Lamond, Zengerle, Michael, Sapkota, Gopal P., Prescott, Alan R.; id_orcid, Alessio Ciulli, Ciulli, Alessio, Jens Hukelmann, Gopal P Sapkota, Greg M Findlay, Davidson, Lindsay, Lamond, Angus; id_orcid, Alan R Prescott   +17 more
core   +1 more source

Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation

Epigenetics & Chromatin, 2020
Background Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer.
Archit Trivedi, Aanchal Mehrotra, Caitlin E. Baum, Brandon Lewis, Tupa Basuroy, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Vijayasaradhi Setaluri, Ivana L. de la Serna   +9 more
doaj   +1 more source

Interaction between Brd2 and H2A.Z nucleosomes increases following TSA treatment and is dependent on the bromodomains of Brd2.

, 2012
A. H2A.Z and H2A nucleosomes were purified as described in Materials and Methods and eluted material was used for Western blot analysis. Prior to harvest cells were treated with TSA or DMSO (vehicle).
Ryan Draker (121524), Peter Cheung (121536), Thomas Kislinger (121533), Elizabeth Sarcinella (121530), Marlee K. Ng (121527), Vladimir Ignatchenko (121532)   +5 more
core   +1 more source

Challenges and Pitfalls to Diagnosing NUTM1‐Rearranged Neoplasia of the Pancreas by Cytology and Ancillary Studies

Diagnostic Cytopathology, EarlyView.
ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley   +1 more source