Results 51 to 60 of about 5,434 (195)
SREBP1 regulates Lgals3 activation in response to cholesterol loading
Molecular Therapy: Nucleic Acids, 2022 Aberrant smooth muscle cell (SMC) plasticity is etiological to vascular diseases. Cholesterol induces SMC phenotypic transition featuring high LGALS3 (galectin-3) expression.
Jing Li +3 more
doaj +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Effective inhibition and increased Brd2 expression in 3T3-L1 adipocytes.
, 2013 (A) WT 3T3-L1 adipocytes were transfected with the Brd2 shRNA (SiBrd2), scramble shRNA (SiC) plasmids, pmBrd2 and control (pcDNA3.1), respectively. After transfection (48 h), cells were passaged, and treated with selection of antibiotics G418 for stable ...
Jingyu Wang (292122) +9 more
core +1 more source
Spatially restricted loading of BRD2 at DNA double-strand breaks protects H4 acetylation domains and promotes DNA repair [PDF]
, 2017 The n-terminal tail of histone H4 recruits repair proteins, including 53BP1, to DNA double-strand breaks (DSB) and undergoes dynamic acetylation during DSB repair.
Chelsea Carman +2 more
core +2 more sources
Unveiling the folding mechanism of the Bromodomains
Biochemistry and Biophysics Reports, 2017 Bromodomains (BRDs) are small protein domains often present in large multidomain proteins involved in transcriptional regulation in eukaryotic cells. They currently represent valuable targets for the development of inhibitors of aberrant transcriptional ...
Maria Petrosino +6 more
doaj +1 more source
Frontiers in Microbiology, 2020 The rhadinoviruses Kaposi’s Sarcoma-associated herpesvirus (KSHV) and murine gammaherpesvirus (MHV-68) persist in infected hosts in a latent state that is characterized by the absence of virus production and by restricted viral gene expression.
Rishikesh Lotke +10 more
doaj +1 more source
BRD9 inhibition as potential treatment option for testicular germ cell tumors
Andrology, EarlyView.Abstract Background Testicular germ cell tumors (TGCT) are the predominant tumor in younger males. Usually, 5‐year survival rates are quite high, but 15–20% of patients with metastatic non‐seminomas are resistant to standard cisplatin‐based therapy.
Aylin Hansen +5 more
wiley +1 more source
Knockdown of Brd4 reduces inflammation but not Brd2.
, 2014 Cells were transfected with either pooled Brd4 or Brd2 siRNAs (20 nM) or non-specific siRNAs (20 nM). 72 hours post-transfection Brd4 mRNA (A) was quantified by RT-QPCR and nuclear extracts were analysed (B) by immunoblotting using anti-Brd4 and -TATA ...
Younis M. Khan (554747) +3 more
core +1 more source
ChemBioChem, Volume 27, Issue 13, 14 July 2026.The function of bromodomain‐containing proteins in regulating gene transcription is reviewed here, including the development of chemical probes and targeted protein degradation modalities (e.g., PROTACs). This extends to clinical efforts targeting the BET bromodomain‐containing proteins. Challenges of selectivity, future prospects, and the differential
Cole R. Scholtz, William C. K. Pomerantz
wiley +1 more source
A model of Brd2 recruitment to AR–regulated genes.
, 2012 Following hormone stimulation, Brd2 is recruited to H2A.Z nucleosomes containing acetylated H4 lysines. Association of Brd2 with histone acetyltransferase (HAT) activity promotes acetylation of neighboring nucleosomes. Recruitment of chromatin remodeling
Ryan Draker (121524) +5 more
core +1 more source