Results 31 to 40 of about 5,434 (195)

Oocyte Meiotic Competence in the Domestic Cat Model: Novel Roles for Nuclear Proteins BRD2 and NPM1

Frontiers in Cell and Developmental Biology, 2021
To participate in fertilization and embryo development, oocytes stored within the mammalian female ovary must resume meiosis as they are arrested in meiotic prophase I.
Daniela R. Chavez, Pei-Chih Lee, Pierre Comizzoli   +2 more
doaj   +1 more source

No evidence for a BRD2 promoter hypermethylation in blood leukocytes of Europeans with juvenile myoclonic epilepsy. [PDF]

, 2019
Juvenile myoclonic epilepsy (JME) is a common syndrome of genetic generalized epilepsies (GGEs). Linkage and association studies suggest that the gene encoding the bromodomain-containing protein 2 (BRD2) may increase risk of JME.
Scheffer, Ingrid E., Ingrid E. Scheffer, Sander, Thomas, Caglayan, Hande, Ugur Ozbek, Tsortouktzidis, Despina, Saul A. Mullen, Sara Schramm, Kunz, Wolfram S, Ganna Balagura, Oliver, Karen L, Blanche, Amedeo, Ann‐Kathrin Ruppert, Susannah T. Bellows, Lerche, Holger, Schankin, Christoph J., Schulz, Herbert, Møller, Rikke S., Francesca Madia, Kapser, Claudia, Wolfram S. Kunz, Karen L. Oliver, Herbert Schulz, Hande Caglayan, Hoffmann, Per, Per Hoffmann, Becker, Albert J, Berkovic, Samuel F, Oliver, Karen L., Carlo Minetti, Møller, Rikke S; id_orcid, Pasquale Striano, S. Vari, Maria, Schramm, Sara, Bellows, Susannah T., Vari, Maria S., Michele Iacomino, Claudia Kapser, Becker, Albert J., Weber, Yvonne G., Holger Lerche, Becker, Felicitas, S Vari, Maria, Mullen, Saul A., Mullen, Saul A, Federico Zara, Moller, Rikke S., Minetti, Carlo, Striano, Pasquale, Scheffer, Ingrid E, Albert J. Becker, Amedeo Bianchi, Samuel F. Berkovic, Weber, Yvonne G, Bianchi, Amedeo, Bellows, Susannah T, Renzo Guerrini, Thomas Sander, Berkovic, Samuel F., Schankin, Christoph J, Maria S. Vari, Yvonne G. Weber, Guerrini, Renzo, Felicitas Becker, Zara, Federico, Marini, Carla, Rikke S. Møller, Despina Tsortouktzidis, Kunz, Wolfram S., Balagura, Ganna, Christoph J. Schankin, Ruppert, Ann-Kathrin, Ozbek, Ugur, Møller, Rikke S, Carla Marini, Madia, Francesca, Iacomino, Michele   +76 more
core   +3 more sources

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell. [PDF]

PLoS ONE, 2016
Displacement of Bromodomain and Extra-Terminal (BET) proteins from chromatin has promise for cancer and inflammatory disease treatments, but roles of BET proteins in metabolic disease remain unexplored.
Jude T Deeney, Anna C Belkina, Orian S Shirihai, Barbara E Corkey, Gerald V Denis   +4 more
doaj   +1 more source

Identification of a Bromodomain-containing Protein 2 (BRD2) Gene Polymorphic Variant and Its Effects on Pork Quality Traits in Berkshire Pigs

Food Science of Animal Resources, 2018
Bromodomain-containing protein 2 (BRD2) is a nuclear serine/threonine kinase involved in transcriptional regulation. We investigated the expression and association of the BRD2 gene as a candidate gene for meat quality traits in Berkshire pigs.
Dong Ju Lee, Jung Hye Hwang, Jeongim Ha, Go Eun Yu, Seulgi Kwon, Da Hye Park, Deok Gyeong Kang, Tae Wan Kim, Hwa Chun Park, Sang Mi An, Chul Wook Kim   +10 more
doaj   +1 more source

Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A [PDF]

Biochemical Journal, 2005
Cyclin A is regulated primarily through transcription control during the mammalian cell cycle. A dual mechanism of cyclin A transcriptional repression involves, on the one hand, promoter-bound inhibitory complexes of E2F transcription factors and RB (retinoblastoma) family proteins, and on the other, chromatin-directed histone deacetylase activity that
Anupama, Sinha, Douglas V, Faller, Gerald V, Denis   +2 more
openaire   +2 more sources

Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations

Scientific Reports, 2017
RVX-208 is a recently reported inhibitor of bromo and extraterminal (BET) family proteins (including BRD2-4 and BRDT) with selectivity for the second bromodomain (BD2), currently in phase III clinical trials.
Qianqian Wang, Ying Li, Jiahui Xu, Yuwei Wang, Elaine Lai-Han Leung, Liang Liu, Xiaojun Yao   +6 more
doaj   +1 more source

Chicken bromodomain-containing protein 2 interacts with the Newcastle disease virus matrix protein and promotes viral replication

Veterinary Research, 2020
Bromodomain-containing protein 2 (BRD2) is a nucleus-localized serine-threonine kinase that plays pivotal roles in the transcriptional control of diverse genes.
Zhiqiang Duan, Yifan Han, Lei Zhou, Chao Yuan, Yanbi Wang, Caiqin Zhao, Hong Tang, Jiaqi Chen   +7 more
doaj   +1 more source

The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells

Frontiers in Oncology, 2022
We reported previously that the BET inhibitor (BETi) JQ1 decreases levels of the DNA repair protein RAD51 and that this decrease is concomitant with increased levels of DNA damage.
Patrick L. Garcia, Aubrey L. Miller, Ling Zeng, Ling Zeng, Robert C. A. M. van Waardenburg, Eddy S. Yang, Eddy S. Yang, Eddy S. Yang, Karina J. Yoon   +8 more
doaj   +1 more source

Targeting BET Proteins Decreases Hyaluronidase-1 in Pancreatic Cancer

Cells, 2023
Background: Pancreatic ductal adenocarcinoma (PDAC) is characterized by the presence of dense stroma that is enriched in hyaluronan (HA), with increased HA levels associated with more aggressive disease.
Krishan Kumar, Deepak Kanojia, David J. Bentrem, Rosa F. Hwang, Jonathan P. Butchar, Susheela Tridandapani, Hidayatullah G. Munshi   +6 more
doaj   +1 more source

Association of the carriage of BRD2 rs206787 and rs516535 and GJD2 rs3743123 polymorphisms with juvenile myoclonic epilepsy in Caucasian patients of Siberia

Неврология, нейропсихиатрия, психосоматика, 2019
In recent years, the genetics of juvenile myoclonic epilepsy (JME) has been actively studied; the association of JME with the carriage of polymorphic allelic variants of the BRD2 (EJM3 locus) and GJD2 (EJM2 locus) genes has been established.
O. S. Shilkina, N. A. Shnayder, S. N. Zobova, D. V. Dmitrenko, P. V. Moskaleva   +4 more
doaj   +1 more source