Results 21 to 30 of about 5,434 (195)

Lyar-Mediated Recruitment of Brd2 to the Chromatin Attenuates Nanog Downregulation Following Induction of Differentiation

Journal of Molecular Biology, 2018
During development, cellular differentiation programs need tight regulation for proper display of the activity of multiple factors in time and space. Chromatin adaptors of the BET family (Brd2, Brd3, Brd4 and Brdt in vertebrates) are transcription co-regulators tightly associated with the progression of the cell cycle.
Luna-Peláez, Noelia, García-Domínguez, Mario   +1 more
openaire   +4 more sources

Pleiotrophin fights Brd2 for neuronal differentiation

Neural Regeneration Research, 2015
Work in M G-D lab is supported by Ministry of Economy and Competitiveness, Spain (MINECO), grant number BFU2012-37304, and by Junta de Andalucía, Spain, grant number P12-CTS-2064.
Pablo Garcia-Gutierrez, Mario Garcia-Dominguez   +1 more
doaj   +4 more sources

New mechanism of chromatin compartmentalization by BRD2

Trends in Genetics, 2022
The molecular mechanism underlying 3D genome compartmentalization remains a mystery. Xie et al. found that the bromodomain and extraterminal (BET) family scaffold protein BRD2 promotes the compartmentalization of the accessible chromatin domains after cohesin loss.
Yubao Cheng, Siyuan Wang
openaire   +2 more sources

Zebrafish Paralogs brd2a and brd2b Are Needed for Proper Circulatory, Excretory and Central Nervous System Formation and Act as Genetic Antagonists during Development

Journal of Developmental Biology, 2021
Brd2 belongs to the BET family of epigenetic transcriptional co-regulators that act as adaptor-scaffolds for the assembly of chromatin-modifying complexes and other factors at target gene promoters. Brd2 is a protooncogene and candidate gene for juvenile
Gregory L. Branigan, Kelly S. Olsen, Isabella Burda, Matthew W. Haemmerle, Jason Ho, Alexandra Venuto, Nicholas D. D’Antonio, Ian E. Briggs, Angela J. DiBenedetto   +8 more
doaj   +1 more source

BRD2 inhibition blocks SARS-CoV-2 infection by reducing transcription of the host cell receptor ACE2 [PDF]

, 2022
SARS-CoV-2 infection of human cells is initiated by the binding of the viral Spike protein to its cell-surface receptor ACE2. We conducted a targeted CRISPRi screen to uncover druggable pathways controlling Spike protein binding to human cells.
Nuñez, James K, Lui, Irene, Wells, James A., Wells, James A, Oki, Jennifer, Chakrabarti, Lisa A., Maures, Travis, Carlson-Stevermer, Jared, Samelson, Avi J, TenOever, Benjamin R., Tran, Quang Dinh, Weissman, Jonathan S., Carrau, Lucia, Rockwood, Sarah J., Lim, Shion A, Samelson, Avi J., Conklin, Bruce R, Rezelj, Veronica V., Chen, Merissa, Rockwood, Sarah J, Chakrabarti, Lisa A, Lim, Shion A., Wang, Jianhui, Robinot, Rémy, Holden, Kevin, Conklin, Bruce R., Kampmann, Martin, Liu, Na, Guo, Xiaoyan, TenOever, Benjamin R, Ramadoss, Gokul N., Vignuzzi, Marco, Nuñez, James K., Ramadoss, Gokul N, Tian, Ruilin, Kain, Alice Mac, Weissman, Jonathan S, Rezelj, Veronica V   +37 more
core   +2 more sources

Overcoming BET ‐inhibitor JQ1 resistance in aggressive non‐small cell lung cancer by inducing ferroptosis via inhibition of the BRD2 – FTH1 axis [PDF]

FEBS Journal
Stefania Scicchitano, Gianluca Santamariá, Vittoria Monaco   +2 more
exaly   +2 more sources

HDAC11 Suppresses the Thermogenic Program of Adipose Tissue via BRD2 [PDF]

JCI Insight, 2018
Abstract Little is known about the biological function of histone deacetylase 11 (HDAC11), which is the lone class IV HDAC. Here, we demonstrate that deletion of HDAC11 in mice stimulates brown adipose tissue (BAT) formation and beiging of white adipose tissue (WAT).
Rushita A. Bagchi, Bradley S. Ferguson, Matthew S. Stratton, Tianjing Hu, Maria A. Cavasin, Lei Sun, Ying-Hsi Lin, Dianxin Liu, Pilar Londono, Kunhua Song, Maria F. Pino, Lauren M. Sparks, Steven R. Smith, Philipp E. Scherer, Sheila Collins, Edward Seto, Timothy A. McKinsey   +16 more
openaire   +2 more sources

Histone acetylation-dependent clustering of BRD2 instructs transcription dynamics. [PDF]

Nat Genet
Abstract Bromodomain (BD) and extra-terminal domain (BET) proteins are key regulators of RNA polymerase II (Pol II)-mediated transcription and their BDs represent promising drug targets. Yet, the interplay between histone acetylation and the chromatin dynamics of individual BET proteins with respect to transcriptional regulation is ...
Erdogdu NU, Guhathakurta S, Oellers R, Shvedunova M, Morin JA, Patrick EM, Seyfferth J, Deboutte W, Gomez-Auli A, Mittler G, Cissé II, Akhtar A.   +11 more
europepmc   +2 more sources

Brd2 is dispensable for genome compartmentalization and replication timing

, 2023
ABSTRACT Replication Timing (RT) refers to the temporal order in which the genome is replicated during S phase. Early replicating regions correlate with the transcriptionally active, accessible euchromatin (A) compartment, while late replicating regions correlate with the heterochromatin (B) compartment and repressive histone marks ...
Laura Hinojosa-Gonzalez, Jesse L. Turner, Takayo Sasaki, Ferhat Ay, David M. Gilbert   +4 more
openaire   +2 more sources

BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos

BMC Biology, 2022
Background During mammalian preimplantation development, as the fertilized egg develops and differentiates, three cell lineages become specified: trophectoderm (TE), epiblast, and primitive endoderm (PrE).
Mami Tsume-Kajioka, Chiharu Kimura-Yoshida, Kyoko Mochida, Yoko Ueda, Isao Matsuo   +4 more
doaj   +1 more source