Results 61 to 70 of about 5,434 (195)

A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex.

PLoS ONE, 2016
Bromodomain containing proteins recognize the level of histone acetylation and regulate epigenetically controlled processes like gene transcription and chromatin modification.
Shailesh Tripathi, Shruti Mathur, Prashant Deshmukh, Ramu Manjula, Balasundaram Padmanabhan   +4 more
doaj   +1 more source

Bromodomain and Extra-Terminal Proteins in Brain Physiology and Pathology: BET-ing on Epigenetic Regulation

Biomedicines, 2023
BET proteins function as histone code readers of acetylated lysins that determine the positive regulation in transcription of genes involved in cell cycle progression, differentiation, inflammation, and many other pathways. In recent years, thanks to the
Noemi Martella, Daniele Pensabene, Michela Varone, Mayra Colardo, Michele Petraroia, William Sergio, Piergiorgio La Rosa, Sandra Moreno, Marco Segatto   +8 more
doaj   +1 more source

Epigenetic Regulation in Cardiovascular Diseases: Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 6, June 2026.
Environmental and lifestyle exposures reshape the cardiovascular epigenome through coordinated regulation of DNA methylation, histone modifications, noncoding RNAs, and RNA methylation (m6A). These multilayered mechanisms drive enhancer‐centered regulatory network remodeling and epigenomic plasticity in cardiovascular diseases, highlighting emerging ...
Wangzheqi Zhang, Chenyang Mu, Rui Zhao, Runwei Ma, Xuehai Liu, Haoling Zhang, Zengwu Wang, Jing‐jing Zhang   +7 more
wiley   +1 more source

Eμ-BRD2 transgenic mice develop B-cell lymphoma and leukemia [PDF]

Blood, 2004
AbstractTransgenic mice with lymphoid-restricted overexpression of the double bromodomain protein bromodomain-containing 2 (Brd2) develop splenic B-cell lymphoma and, upon transplantation, B-cell leukemia with leukemic infiltrates in liver and lung. Brd2 is a nuclear-localized transcription factor kinase that is most closely related to TATA box binding
Rebecca J, Greenwald, Joseph R, Tumang, Anupama, Sinha, Nicolas, Currier, Robert D, Cardiff, Thomas L, Rothstein, Douglas V, Faller, Gerald V, Denis   +7 more
openaire   +2 more sources

Three-dimensional CRISPR screening reveals epigenetic interaction with anti-angiogenic therapy

Communications Biology, 2021
Through three-dimensional CRISPR screening, He et al. report that functional inhibition of BET family of proteins BRD2/3/4 shows mitigating effects on blood endothelial cell (EC) survival and/or proliferation upon VEGFA blockade.
Michael Y. He, Michael M. Halford, Ruofei Liu, James P. Roy, Zoe L. Grant, Leigh Coultas, Niko Thio, Omer Gilan, Yih-Chih Chan, Mark A. Dawson, Marc G. Achen, Steven A. Stacker   +11 more
doaj   +1 more source

MYC Addiction as a Targetable Vulnerability in Nelarabine‐Resistant T‐Cell Acute Lymphoblastic Leukemia

Cancer Science, Volume 117, Issue 6, Page 1608-1622, June 2026.
MYC drives nelarabine resistance in T‐ALL via a hyperactive transcriptional program. Pharmacological degradation of BET proteins dismantles this addiction, restoring drug sensitivity and extending survival in vivo. ABSTRACT Acquired resistance represents a fundamental obstacle limiting the long‐term efficacy of cancer chemotherapy.
Jingjing Gao, Chunxu Lin, Suchang Chen, Qi Mo, Chu Bao, Huali Deng, Ziyin Chen, Weichao Hao, Luyong Zhang, Min Wei   +9 more
wiley   +1 more source

Double bromodomain‐containing gene Brd2 is essential for embryonic development in mouse [PDF]

Developmental Dynamics, 2009
AbstractThe BET subfamily of bromodomain‐containing genes is characterized by the presence of two bromodomains and a unique ET domain at their carboxyl termini. Here, we show that the founding member of this subfamily, Brd2, is an essential gene by generating a mutant mouse line lacking Brd2 function.
Enyuan, Shang, Xiangyuan, Wang, Duancheng, Wen, David A, Greenberg, Debra J, Wolgemuth   +4 more
openaire   +2 more sources

OsGSK2‐OsTCP19 Module Integrates Nitrogen and Brassinosteroid Signaling to Regulate Nitrogen Utilization and Root Growth in Rice

Advanced Science, Volume 13, Issue 30, 28 May 2026.
OsGSK2‐OsTCP19 module regulating nitrate response and lateral root (LR) development. Low‐nitrate condition results in reduced BR response, accumulation of OsGSK2 and phosphorylated OsTCP19, which suppresses the expression of nitrate‐responsive genes and LR‐development genes and impairs rice growth.
Yongqiang Liu, Weiwei Li, Xiaohui Ma, Xiaohan Wang, Yarong Shi, Xiahe Huang, Xinran Li, Yingchun Wang, Hongning Tong, Bin Hu, Wenbin Zhou, Chengcai Chu   +11 more
wiley   +1 more source

Structural implications for K5/K12-di-acetylated histone H4 recognition by the second bromodomain of BRD2

, 2010
The BET family proteins recognize acetylated chromatin through their two bromodomains, acting as transcriptional activators or tethering viral genomes to the mitotic chromosomes of their host.
Takashi Umehara, Umehara, Takashi, Nakamura, Yoshihiro, Wakamori, Masatoshi, Yokoyama, Shigeyuki, Yoshihiro Nakamura, Ozato, Keiko, Balasundaram Padmanabhan, Padmanabhan, Balasundaram, Keiko Ozato, Shigeyuki Yokoyama, Masatoshi Wakamori   +11 more
core   +1 more source

Identification of Parkinson’s disease-associated chromatin regulators

Scientific Reports, 2023
Parkinson’s disease (PD) is a common neurological disorder that causes quiescent tremors, motor delays, depression, and sleep disturbances. Existing treatments can only improve symptoms, not stop progression or cure the disease, but effective treatments ...
Hailong Xing, Shanshan Wang, Ke Li
doaj   +1 more source