Results 41 to 50 of about 3,510,874 (207)

Developing inhibitors of bromodomain-histone interactions [PDF]

, 2014
Lysine acetylation is a widespread protein post-translational modification that influences diverse cellular processes. An association between acetylation of histone N-terminal tails and transcriptional activation has been recognised since the 1960s ...
Hewings, David Stephen, Conway, Stuart J, Brennan, Paul E   +2 more
core   +2 more sources

BRD4 (bromodomain containing 4) [PDF]

, 2007
Review on BRD4 (bromodomain containing 4), with data on DNA, on the protein encoded, and where the gene is ...
Collin, A
core   +1 more source

Identification and molecular characterization of BP75, a novel bromodomain‐containing protein [PDF]

FEBS Letters, 1999
We here describe the identification and characterization of a novel bromodomain‐containing protein, the bromodomain protein of 75 kDa (BP75). Initially, we identified BP75 in a two‐hybrid screening for proteins that interact with the first PDZ (acronym for post‐synaptic density protein PSD‐95, Drosophila discs large tumor suppressor DlgA and the tight ...
Cuppen, E.P.J.G., Ham, M.A.P.C. van, Pepers, B.A., Wieringa, B., Hendriks, W.J.A.J.   +4 more
openaire   +4 more sources

Rational design and development of selective BRD7 bromodomain inhibitors and their activity in prostate cancer [PDF]

, 2023
Bromodomain-containing proteins are readers of acetylated lysine and play important roles in cancer. Bromo-domain-containing protein 7 (BRD7) has been implicated in multiple malignancies; however, there are no selective chemical probes to study its ...
Sandra, Ordonez, Surbhi, Sood, Alexander, McQuade, Brian , Smith, Sijie, Wang, Emily, Dykhuizen, Brayden, Strohmier, Chad, Maschinot   +7 more
core   +2 more sources

Androgen Receptor Deregulation Drives Bromodomain-Mediated Chromatin Alterations in Prostate Cancer

Cell Reports, 2017
Global changes in chromatin accessibility may drive cancer progression by reprogramming transcription factor (TF) binding. In addition, histone acetylation readers such as bromodomain-containing protein 4 (BRD4) have been shown to associate with these ...
Alfonso Urbanucci, Stefan J. Barfeld, Ville Kytölä, Harri M. Itkonen, Ilsa M. Coleman, Daniel Vodák, Liisa Sjöblom, Xia Sheng, Teemu Tolonen, Sarah Minner, Christoph Burdelski, Kati K. Kivinummi, Annika Kohvakka, Steven Kregel, Mandeep Takhar, Mohammed Alshalalfa, Elai Davicioni, Nicholas Erho, Paul Lloyd, R. Jeffrey Karnes, Ashley E. Ross, Edward M. Schaeffer, Donald J. Vander Griend, Stefan Knapp, Eva Corey, Felix Y. Feng, Peter S. Nelson, Fahri Saatcioglu, Karen E. Knudsen, Teuvo L.J. Tammela, Guido Sauter, Thorsten Schlomm, Matti Nykter, Tapio Visakorpi, Ian G. Mills   +34 more
doaj   +1 more source

Integrated genomic analysis of the 8q24 amplification in endometrial cancers identifies ATAD2 as essential to MYC-dependent cancers. [PDF]

PLoS ONE, 2013
Chromosome 8q24 is the most commonly amplified region across multiple cancer types, and the typical length of the amplification suggests that it may target additional genes to MYC.
Maria B Raeder, Even Birkeland, Jone Trovik, Camilla Krakstad, Shyemaa Shehata, Steven Schumacher, Travis I Zack, Antje Krohn, Henrica Mj Werner, Susan E Moody, Elisabeth Wik, Ingunn M Stefansson, Frederik Holst, Anne M Oyan, Pablo Tamayo, Jill P Mesirov, Karl H Kalland, Lars A Akslen, Ronald Simon, Rameen Beroukhim, Helga B Salvesen   +20 more
doaj   +1 more source

BET bromodomain proteins regulate enhancer function during adipogenesis [PDF]

, 2018
Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of PPARγ and C/EBPα, which orchestrate activation of the adipocyte gene expression program ...
Young, Richard A., Jaime M. Reyes, Rahl, Peter B., Qiong Duan, Charles Y. Lin, Doherty, Sean P., Duan, Qiong, Plutzky, Jorge, Saptarsi M. Haldar, Richard A. Young, Peter B. Rahl, Federation, Alexander J., Reyes, Jaime M., Quanhu Sheng, Brown, Jonathan D., Haldar, Saptarsi M., Lin, Charles Y., Zachary B. Feldman, Bradner, James E., Alexander J. Federation, Andrew L. Kung, Feldman, Zachary B., Jorge Plutzky, Sheng, Quanhu, James E. Bradner, Kung, Andrew L., Sean P. Doherty, Jonathan D. Brown   +27 more
core   +1 more source

Design of a chemical probe for the Bromodomain and Plant Homeodomain Finger-containing (BRPF) family of proteins [PDF]

, 2017
The bromodomain and PHD finger-containing (BRPF) family are scaffolding proteins important for the recruitment of histone acetyltransferases of the MYST family to chromatin.
Boyd, H, Savitsky, P, Meier, JC, Cheasty, A, Brennan, PE, Stefan Knapp, Catherine Rogers, David M. Andrews, Müller, S, Yannick Morias, Cunoosamy, D, Anne Cheasty, Fedorov, Oleg, Helen Boyd, Danen Cunoosamy, Elliott D. Bayle, Müller, Susanne, Oleg Fedorov, Rogers, C, Niall Igoe, Scholze, S, Knapp, Stefan, Cynthia Tallant, Sarah Scholze, Julia C. Meier, Tallant, C, Knapp, S, Tallant, Cynthia, Paul E. Brennan, Morias, Y, Susanne Müller, Rogers, Catherine, Brennan, Paul, Pavel Savitsky, Bayle, ED, Igoe, N, Savitsky, Pavel, Andrews, DM, Paul V. Fish, Fedorov, O, Meier, Julia C, Fish, PV   +41 more
core   +2 more sources

BRD4 PROTAC degrader MZ1 exhibits anti-B-cell acute lymphoblastic leukemia effects via targeting CCND3

Hematology, 2023
Introduction B-cell acute lymphoblastic leukemia (B-ALL) is the most prevalent malignant tumor affecting children. While the majority of B-ALL patients (90%) experience successful recovery, early relapse cases of B-ALL continue to exhibit high mortality ...
Li Ma, Jianwei Wang, Yang Yang, Jun Lu, Jing Ling, Xinran Chu, Zimu Zhang, Yanfang Tao, Xiaolu Li, Yuanyuan Tian, Zhiheng Li, Yongping Zhang, Xu Sang, Lihui Lu, Xiaomei Wan, Kunlong Zhang, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Jian Pan, Xiuxia Zhou, Yixin Hu, Shaoyan Hu   +23 more
doaj   +1 more source

Genome-wide survey of D/E repeats in human proteins uncovers their instability and aids in identifying their role in the chromatin regulator ATAD2

iScience, 2022
Summary: D/E repeats are stretches of aspartic and/or glutamic acid residues found in over 150 human proteins. We examined genomic stability of D/E repeats and functional characteristics of D/E repeat-containing proteins vis-à-vis the proteins with poly ...
Shalabh Shukla, Pavlo Lazarchuk, Maria N. Pavlova, Julia M. Sidorova   +3 more
doaj   +1 more source