Results 21 to 30 of about 3,510,874 (207)
Bromodomain-Containing Protein BRD4 Is Hyperphosphorylated in Mitosis [PDF]
Cancers, 2020 The epigenetic reader BRD4 binds acetylated histones and plays a central role in controlling cellular gene transcription and proliferation. Dysregulation of BRD4′s activity has been implicated in the pathogenesis of a wide variety of cancers. While blocking BRD4 interaction with acetylated histones using BET inhibitors (BETis) has been tested in ...
Ranran Wang +4 more
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Sevoflurane attenuates myocardial ischemia/reperfusion injury by up-regulating microRNA-99a and down-regulating BRD4 [PDF]
Acta Cirúrgica Brasileira, 2023 Purpose: It has been explored that sevoflurane (Sevo) is cardioprotective in myocardial ischemia/reperfusion injury (MI/RI) and mediates microRNA (miRNA) expression that control various physiological systems.
Xiaomin Bie, Jiying Ao, Degang Zhu
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The Aggregation of ATAD2 Bromodomain in Solution
Chinese Journal of Magnetic Resonance, 2023 ATPase family AAA domain-containing protein 2 (ATAD2) is a chromatin regulator, also known as an oncogenic transcription cofactor. Its abnormal expression is closely related to the occurrence and development of various malignant tumors. ATAD2 consists of
WANG Yuanfang +5 more
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Bromodomain-containing protein BRPF1 is a therapeutic target for liver cancer [PDF]
Communications Biology, 2021 AbstractEpigenetic deregulation plays an essential role in hepatocellular carcinoma (HCC) progression. Bromodomains are epigenetic “readers” of histone acetylation. Recently, bromodomain inhibitors have exhibited promising therapeutic potential for cancer treatment.
Carol Lai-Hung Cheng +10 more
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mSystems, 2019 To better understand the transcriptomic interplay of organisms associated with lymphatic filariasis, we conducted multispecies transcriptome sequencing (RNA-Seq) on the filarial nematode Brugia malayi, its Wolbachia endosymbiont wBm, and its laboratory ...
Matthew Chung +11 more
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Investigating bromodomain proteins as targets for antileishmanial drug discovery [PDF]
, 2022 Leishmania is a kinetoplastid parasite and the causative agent of the neglected tropical disease, leishmaniasis. Despite the high disease burden, current treatments for leishmaniasis show toxic side effects and growing resistance, so new antileishmanials
Russell, Catherine Nicola
core +5 more sources
The BRPF1 bromodomain is a molecular reader of di-acetyllysine
Current Research in Structural Biology, 2020 Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead to altered expression of genes that drive cancer, inflammation and neurological disorders in humans.
Juliet O. Obi +10 more
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BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
Molecules, 2023 The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer-related and immunity-associated genes.
Kenneth K. W. To +3 more
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Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma Cruzi [PDF]
, 2020 The Trypanosoma cruzi (T. cruzi) parasite is the cause of Chagas disease, a neglected disease endemic in South America. The life cycle of the T. cruzi parasite is complex and includes transitions between distinct life stages.
Andrew, Boczek +13 more
core +2 more sources
Light-Activating PROTACs in Cancer: Chemical Design, Challenges, and Applications
Applied Sciences, 2022 Nonselective cell damage remains a significant limitation of radiation therapies in cancer. Decades of successful integration of radiation therapies with other medicinal chemistry strategies significantly improved therapeutic benefits in cancer ...
Arvind Negi +2 more
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