Results 11 to 20 of about 16,709 (213)

Bromodomain-containing proteins in prostate cancer [PDF]

Molecular and Cellular Endocrinology, 2017
Several oncogenic factors have been involved in prostate cancer progression. However, therapeutic approaches still focus on suppression of androgen receptor (AR) signaling.
Alfonso Urbanucci, Urbanucci, Alfonso, Urbanucci, A, Mills, Ian G., Mills, Ian G; id_orcid, Mills, Ian Geoffrey, Ian G. Mills   +6 more
core   +6 more sources

Alternative Mechanisms for DNA Engagement by BET Bromodomain-Containing Proteins. [PDF]

Biochemistry, 2022
Epigenetic reader domains regulate chromatin structure and modulate gene expression through the recognition of post-translational modifications on histones. Recently, reader domains have also been found to harbor double-stranded (ds) DNA-binding activity,
Kalra P, Zahid H, Ayoub A, Dou Y, Pomerantz WCK.   +4 more
europepmc   +4 more sources

Bromodomain Proteins in HIV Infection [PDF]

Viruses, 2013
Bromodomains are conserved protein modules of ~110 amino acids that bind acetylated lysine residues in histone and non-histone proteins. Bromodomains are present in many chromatin-associated transcriptional regulators and have been linked to diverse ...
Melanie Ott, Daniela Boehm, Ryan J. Conrad   +2 more
doaj   +2 more sources

Bromodomain and extra-terminal domain (BET) proteins regulate melanocyte differentiation

Epigenetics & Chromatin, 2020
Background Pharmacologic inhibition of bromodomain and extra-terminal (BET) proteins is currently being explored as a new therapeutic approach in cancer.
Archit Trivedi, Aanchal Mehrotra, Caitlin E. Baum, Brandon Lewis, Tupa Basuroy, Thomas Blomquist, Robert Trumbly, Fabian V. Filipp, Vijayasaradhi Setaluri, Ivana L. de la Serna   +9 more
doaj   +2 more sources

Application of atypical acetyl-lysine methyl mimetics in the development of selective inhibitors of the bromodomain-containing protein 7 (BRD7)/bromodomain-containing protein 9 (BRD9) bromodomains [PDF]

Journal of Medicinal Chemistry, 2020
Non-BET bromodomain containing proteins have become attractive targets for the development of novel therapeutics targeting epigenetic pathways. To help facilitate the target validation of this class of proteins, structurally diverse small molecule ...
Leveridge, Melanie, Rioja, Inmaculada, Grandi, Paola, Theodoulou, Natalie H., Bamborough, Paul, Werner, Thilo, Prinjha, Rab K., Lindon, Matthew, Michon, Anne-Marie, Soden, Peter E., Chung, Chun-wa, Tomkinson, Nicholas C. O., Gordon, Laurue, Liwicki, Gemma M., Clegg, Michael A., Craggs, Peter D., Molnar, Judit, Humphreys, Philip G.   +17 more
core   +5 more sources

A Minireview on BET Inhibitors: Beyond Bromodomain Targeting

Biomedicines
Bromodomain and extra-terminal domain (BET) proteins are epigenetic readers that recognize the histone acetylation code and play a critical role in regulating gene transcription.
Mikhail S. Iudin, Yuri M. Khodarovich, Anna M. Varizhuk, Vladimir B. Tsvetkov, Vyacheslav V. Severov   +4 more
doaj   +2 more sources

Spotlight on Plant Bromodomain Proteins

Biology, 2023
Bromodomain-containing proteins (BRD-proteins) are the “readers” of histone lysine acetylation, translating chromatin state into gene expression.
Eirini Bardani, Paraskevi Kallemi, Martha Tselika, Konstantina Katsarou, Kriton Kalantidis   +4 more
doaj   +2 more sources

Identification and molecular characterization of BP75, a novel bromodomain-containing protein [PDF]

FEBS Letters, 1999
We here describe the identification and characterization of a novel bromodomain-containing protein, the bromodomain protein of 75 kDa (BP75). Initially, we identified BP75 in a two-hybrid screening for proteins that interact with the first PDZ (acronym ...
Cuppen, E., Wiljan Hendriks, van Ham, Marco, Wieringa, B., van Ham, M., Marco van Ham, Wieringa, Bé, Barry Pepers, Pepers, B.A., Edwin Cuppen, Hendriks, W., Hendriks, Wiljan, Pepers, Barry, Pepers, B., Bé Wieringa, Cuppen, E.P.J.G., Cuppen, Edwin, Ham, M.A.P.C. van, Hendriks, W.J.A.J.   +18 more
core   +5 more sources

Bromodomain inhibitors and cancer therapy: From structures to applications

Epigenetics, 2017
Aberrations in the epigenetic landscape are a hallmark of cancer. Alterations in enzymes that are “writers,” “erasers,” or “readers” of histone modification marks are common. Bromodomains are “readers” that bind acetylated lysines in histone tails. Their
Montserrat Pérez-Salvia, Manel Esteller
doaj   +2 more sources

A Review of the Bromodomain and Extraterminal Domain Epigenetic Reader Proteins: Function on Virus Infection and Cancer

Viruses
The BET (bromodomain and extraterminal domain) family of proteins, particularly BRD4 (bromodomain-containing protein 4), plays a crucial role in transcription regulation and epigenetic mechanisms, impacting key cellular processes such as proliferation ...
Mengli Wu, Guiquan Guan, Hong Yin, Qingli Niu   +3 more
doaj   +2 more sources