Results 61 to 70 of about 16,709 (213)

BET bromodomain proteins regulate enhancer function during adipogenesis

, 2018
Developmental transitions are guided by master regulatory transcription factors. During adipogenesis, a transcriptional cascade culminates in the expression of PPARγ and C/EBPα, which orchestrate activation of the adipocyte gene expression program ...
Young, Richard A., Jaime M. Reyes, Rahl, Peter B., Qiong Duan, Charles Y. Lin, Doherty, Sean P., Duan, Qiong, Plutzky, Jorge, Saptarsi M. Haldar, Richard A. Young, Peter B. Rahl, Federation, Alexander J., Reyes, Jaime M., Quanhu Sheng, Brown, Jonathan D., Haldar, Saptarsi M., Lin, Charles Y., Zachary B. Feldman, Bradner, James E., Alexander J. Federation, Andrew L. Kung, Feldman, Zachary B., Jorge Plutzky, Sheng, Quanhu, James E. Bradner, Kung, Andrew L., Sean P. Doherty, Jonathan D. Brown   +27 more
core   +1 more source

Selectivity Mechanism of Pyrrolopyridone Analogues Targeting Bromodomain 2 of Bromodomain-Containing Protein 4 from Molecular Dynamics Simulations

ACS Omega, 2023
Bromodomain and extra-terminal domain (BET) proteins play an important role in epigenetic regulation and are linked to several diseases; therefore, they are interesting targets. BET has two bromodomains: bromodomain 1 (BD1) and BD2. Selective targeting of BD1 or BD2 may produce different activities and greater effects than pan-BD inhibitors.
Mingsong Shi, Xueting Zheng, Yan Zhou, Yuan Yin, Zhou Lu, Zhiyan Zou, Yan Hu, Yuanyuan Liang, Tingting Chen, Yuhan Yang, Meng Jing, Dan Lei, Pei Yang, Xiaoan Li   +13 more
openaire   +3 more sources

ANKS1B in the Nucleus Accumbens Controls Escalated Cocaine Self‐Administration via Regulating CBP‐FoxO3 Complex

Advanced Science, EarlyView.
ANKS1B in the nucleus accumbens plays a critical role in the transition from controlled to escalated cocaine intake. Mechanistically, ANKS1B interacts with CBP to epigenetically suppress FoxO3 through H3K27 acetylation. The ANKS1B‐CBP‐FoxO3 signaling cascade presents a novel theraputic target for the treatment of cocaine addiction.
Liping Yang, Xiaoxuan Wu, Xuan Chen, Chao Peng, Zihang Li, Shumin Gao, Shiqiu Meng, Jing Dong, Dong Wu, Liying Lv, Ying Han, Yanxue Xue, Lin Lu, Jie Shi, Jianfeng Liu, Yan Sun   +15 more
wiley   +1 more source

Bromodomain-containing Proteins in HIV Transcription & Latency [PDF]

, 2016
HIV-1 latency is a phenomenon of transcriptional silencing wherein components of the host epigenetic machinery impose reversible restrictions to viral chromatin.
Conrad, Ryan J.
core  

Discovery of RSV-Induced BRD4 Protein Interactions Using Native Immunoprecipitation and Parallel Accumulation—Serial Fragmentation (PASEF) Mass Spectrometry

Viruses, 2021
Respiratory Syncytial Virus (RSV) causes severe inflammation and airway pathology in children and the elderly by infecting the epithelial cells of the upper and lower respiratory tract.
Morgan Mann, David S. Roberts, Yanlong Zhu, Yi Li, Jia Zhou, Ying Ge, Allan R. Brasier   +6 more
doaj   +1 more source

Harnessing MDM2‐Mediated Targeted Degradation of Transcriptional and Epigenetic Machinery to Disrupt Oncogenic Addictions in Pediatric Sarcoma

Advanced Science, EarlyView.
MDM2 dependency in pediatric sarcomas is driven by a novel p53‐independent oncogenic cistrome alongside canonical p53 pathway suppression. This study introduces MDM2‐recruiting transcriptional and epigenetic machinery degraders (MDM2‐TEMADs) as a novel precision oncology modality.
Jiawei Zhou, Xian Guan, Nan Li, Ying Zhang, Long Xie, Xingze Huang, Zhipeng Zhu, Zhuolin Ren, Xiaoyan Yu, Hanjun Guo, Yuanfang Wu, Lin Ma, Suya Zheng, Jingyao Zhang, Jiyang Liu, Victor Kuanmin Lee, Wenhao Chen, H. Phillip Koeffler, Jinhu Wang, Xin Han, Ye Chen, Liang Xu   +21 more
wiley   +1 more source

An emerging role for bromodomain‐containing proteins in chromatin regulation and transcriptional control of adipogenesis [PDF]

FEBS Letters, 2010
Transcriptional co‐activators, co‐repressors and chromatin remodeling machines are essential elements in the transcriptional programs directed by the master adipogenic transcription factor PPARγ. Many of these components have orthologs in other organisms, where they play roles in development and pattern formation, suggesting new links between cell fate
Denis, Gerald V., Nikolajczyk, Barbara S., Schnitzler, Gavin R.   +2 more
openaire   +2 more sources

Growth and Early Postimplantation Defects in Mice Deficient for the Bromodomain-Containing Protein Brd4 [PDF]

Molecular and Cellular Biology, 2002
In a gene trap screen we recovered a mouse mutant line in which an insertion generated a null allele of the Brd4 gene. Brd4 belongs to the Fsh/Brd family, a group of structurally related proteins characterized by the association of two bromodomains and one extraterminal domain.
Houzelstein, Denis, Bullock, Simon L, Lynch, Denise E, Grigorieva, Elena F, Wilson, Valerie A, Beddington, Rosa S P   +5 more
openaire   +2 more sources

A Novel Phenanthridionone Based Scaffold As a Potential Inhibitor of the BRD2 Bromodomain: Crystal Structure of the Complex.

PLoS ONE, 2016
Bromodomain containing proteins recognize the level of histone acetylation and regulate epigenetically controlled processes like gene transcription and chromatin modification.
Shailesh Tripathi, Shruti Mathur, Prashant Deshmukh, Ramu Manjula, Balasundaram Padmanabhan   +4 more
doaj   +1 more source

Impact of HDAC Inhibitors on Protein Quality Control Systems: Consequences for Precision Medicine in Malignant Disease

Frontiers in Cell and Developmental Biology, 2020
Lysine acetylation is one of the major posttranslational modifications (PTM) in human cells and thus needs to be tightly regulated by the writers of this process, the histone acetyl transferases (HAT), and the erasers, the histone deacetylases (HDAC ...
Linda Anna Michelle Kulka, Pia-Victoria Fangmann, Diana Panfilova, Heidi Olzscha   +3 more
doaj   +1 more source