Results 81 to 90 of about 16,709 (213)
PLoS ONE, 2019 Spermatogenesis in Drosophila melanogaster is characterized by a specific transcriptional program during the spermatocyte stage. Transcription of thousands of genes is regulated by the interaction of several proteins or complexes, including a tTAF ...
Tim Hundertmark +8 more
doaj +1 more source
AKT, ATR, and Notch Inhibitors Radiosensitize a Preclinical Model of Adenoid Cystic Carcinoma
Head &Neck, EarlyView.ABSTRACT Background Adenoid Cystic Carcinoma (ACC) is a rare and lethal type of head and neck cancer. Standard therapy involves surgery followed by radiation therapy. The majority of ACC has MYB overexpression and MYB‐NFIB gene fusions, while Notch mutations are associated with aggressive behavior.
Shivani Thoidingjam +10 more
wiley +1 more source
, 2016 Chromatin modifying proteins are attractive drug targets in oncology, given the fundamental reliance of cancer on altered transcriptional activity. Multiple transcription factors can be impacted downstream of primary target inhibition, thus making it ...
Daniel E. Spratt (1385634) +8 more
core +1 more source
Mucosal bromodomain-containing protein 4 mediates aeroallergen-induced inflammation and remodeling [PDF]
Journal of Allergy and Clinical Immunology, 2019 Frequent exacerbations of allergic asthma lead to airway remodeling and a decrease in pulmonary function, producing morbidity. Cat dander is an aeroallergen associated with asthma risk.We sought to elucidate the mechanism of cat dander-induced inflammation-remodeling.We identified remodeling in mucosal samples from allergic asthma by using quantitative
Bing, Tian +11 more
openaire +2 more sources
Cell Reports, 2017 Summary: BET inhibitors (BETi) target bromodomain-containing proteins and are currently being evaluated as anti-cancer agents. We find that maximal therapeutic effects of BETi in a Myc-driven B cell lymphoma model required an intact host immune system ...
Simon J. Hogg +17 more
doaj +1 more source
Head &Neck, EarlyView.ABSTRACT Introduction Sinonasal cancers are rare and heterogeneous and pose a therapeutic challenge at an advanced stage due to the lack of data on appropriate systemic management. Methods This retrospective multicenter study analyzed 83 patients with recurrent or metastatic sinonasal carcinomas ineligible for curative treatment, treated in France ...
Marie Degrange +16 more
wiley +1 more source
Discovery of Highly Potent BET Inhibitors based on a Tractable Tricyclic Scaffold
The bromodomain and extra-terminal domain (BET) protein family is a class of epigenetic reader proteins that recognize N-acetylated lysine residues in histone tails, playing a crucial role in gene expression and cell transcription.
Zaidi, Jaffer M. +5 more
core +1 more source
Deregulation of bromodomain-containing proteins BRPF1 and BRD9 in hepatocellular carcinoma
, 2020 Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. HCC treatment is very challenging, which is mainly due to the lack of early diagnostic tools and limited treatment options.
Cheng, Carol Lai Hung, 鄭麗紅
core
, 2015 Bromodomain-containing protein dysregulation is linked to cancer, diabetes, and inflammation. Selective inhibition of bromodomain function is a newly proposed therapeutic strategy.
Jennifer L. Hall (474586) +9 more
core +2 more sources
Acetylation-Dependent Chromatin Reorganization by BRDT, a Testis-Specific Bromodomain-Containing Protein [PDF]
Molecular and Cellular Biology, 2003 The association between histone acetylation and replacement observed during spermatogenesis prompted us to consider the testis as a source for potential factors capable of remodelling acetylated chromatin. A systematic search of data banks for open reading frames encoding testis-specific bromodomain-containing proteins focused our attention on BRDT, a ...
Christophe, Pivot-Pajot +5 more
openaire +2 more sources